Alternative Splicing

"Alternative Splicing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.

Descriptor ID	D017398
MeSH Number(s)	G02.111.760.700.100 G03.839.700.100 G05.308.700.700.100
Concept/Terms	Alternative Splicing Alternative Splicing Alternative Splicings Splicings, Alternative Alternate Splicing Alternate Splicings Splicing, Alternate Splicings, Alternate RNA Splicing, Alternative Alternative RNA Splicing Alternative RNA Splicings RNA Splicings, Alternative Splicing, Alternative RNA Splicings, Alternative RNA Splicing, Alternative Nested Transcripts Nested Transcripts Nested Transcript Transcript, Nested Transcripts, Nested

Below are MeSH descriptors whose meaning is more general than "Alternative Splicing".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
RNA Processing, Post-Transcriptional [G02.111.760]
RNA Splicing [G02.111.760.700]
Alternative Splicing [G02.111.760.700.100]
Metabolism [G03]
RNA Processing, Post-Transcriptional [G03.839]
RNA Splicing [G03.839.700]
Alternative Splicing [G03.839.700.100]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
RNA Processing, Post-Transcriptional [G05.308.700]
RNA Splicing [G05.308.700.700]
Alternative Splicing [G05.308.700.700.100]

Below are MeSH descriptors whose meaning is related to "Alternative Splicing".

Below are MeSH descriptors whose meaning is more specific than "Alternative Splicing".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Alternative Splicing" by people in this website by year, and whether "Alternative Splicing" was a major or minor topic of these publications.

Bar chart showing 74 publications over 26 distinct years, with a maximum of 6 publications in 2002 and 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	1	1	2
1994	0	1	1
1995	0	3	3
1996	1	2	3
1998	1	4	5
1999	2	3	5
2000	1	3	4
2001	0	2	2
2002	2	4	6
2003	0	3	3
2004	2	4	6
2005	2	2	4
2006	2	2	4
2007	3	1	4
2008	0	2	2
2009	1	0	1
2010	0	1	1
2011	0	1	1
2012	1	4	5
2013	2	0	2
2014	2	1	3
2015	1	0	1
2016	1	0	1
2018	1	0	1
2019	0	2	2
2021	1	1	2

Below are the most recent publications written about "Alternative Splicing" by people in Profiles.

Li H, Rajani V, Han L, Chung D, Cooke JE, Sengar AS, Salter MW. Alternative splicing of GluN1 gates glycine site-dependent nonionotropic signaling by NMDAR receptors. Proc Natl Acad Sci U S A. 2021 07 06; 118(27).

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Zhang X, Ameer FS, Azhar G, Wei JY. Alternative Splicing Increases Sirtuin Gene Family Diversity and Modulates Their Subcellular Localization and Function. Int J Mol Sci. 2021 Jan 06; 22(2).

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Khan I, Rhett JM, O'Bryan JP. Therapeutic targeting of RAS: New hope for drugging the "undruggable". Biochim Biophys Acta Mol Cell Res. 2020 02; 1867(2):118570.

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Hirose T, Cabrera-Socorro A, Chitayat D, Lemonnier T, Féraud O, Cifuentes-Diaz C, Gervasi N, Mombereau C, Ghosh T, Stoica L, Bacha JDA, Yamada H, Lauterbach MA, Guillon M, Kaneko K, Norris JW, Siriwardena K, Blasér S, Teillon J, Mendoza-Londono R, Russeau M, Hadoux J, Ito S, Corvol P, Matheus MG, Holden KR, Takei K, Emiliani V, Bennaceur-Griscelli A, Schwartz CE, Nguyen G, Groszer M. ATP6AP2 variant impairs CNS development and neuronal survival to cause fulminant neurodegeneration. J Clin Invest. 2019 04 15; 129(5):2145-2162.

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Penrod RD, Anderson EM, Cowan CW. Any Way You Splice It: New Molecular Mechanisms of Cocaine-Induced Alternative Gene Expression. Biol Psychiatry. 2018 08 01; 84(3):162-164.

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Labuzzetta CJ, Antonio ML, Watson PM, Wilson RC, Laboissonniere LA, Trimarchi JM, Genc B, Ozdinler PH, Watson DK, Anderson PE. Complementary feature selection from alternative splicing events and gene expression for phenotype prediction. Bioinformatics. 2016 09 01; 32(17):i421-i429.

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Twal WO, Hammad SM, Guffy SL, Argraves WS. A novel intracellular fibulin-1D variant binds to the cytoplasmic domain of integrin beta 1 subunit. Matrix Biol. 2015 Apr; 43:97-108.

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Cantini LP, Andino LM, Attaway CC, Butler B, Dumitriu A, Blackshaw A, Jakymiw A. Identification and characterization of Dicer1e, a Dicer1 protein variant, in oral cancer cells. Mol Cancer. 2014 Aug 13; 13:190.

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Nance T, Smith KS, Anaya V, Richardson R, Ho L, Pala M, Mostafavi S, Battle A, Feghali-Bostwick C, Rosen G, Montgomery SB. Transcriptome analysis reveals differential splicing events in IPF lung tissue. PLoS One. 2014; 9(5):e97550.

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Nance T, Smith KS, Anaya V, Richardson R, Ho L, Pala M, Mostafavi S, Battle A, Feghali-Bostwick C, Rosen G, Montgomery SB. Transcriptome analysis reveals differential splicing events in IPF lung tissue. PLoS One. 2014; 9(3):e92111.

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