"Alternative Splicing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.
Descriptor ID |
D017398
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MeSH Number(s) |
G02.111.760.700.100 G03.839.700.100 G05.308.700.700.100
|
Concept/Terms |
Alternative Splicing- Alternative Splicing
- Alternative Splicings
- Splicings, Alternative
- Alternate Splicing
- Alternate Splicings
- Splicing, Alternate
- Splicings, Alternate
- RNA Splicing, Alternative
- Alternative RNA Splicing
- Alternative RNA Splicings
- RNA Splicings, Alternative
- Splicing, Alternative RNA
- Splicings, Alternative RNA
- Splicing, Alternative
Nested Transcripts- Nested Transcripts
- Nested Transcript
- Transcript, Nested
- Transcripts, Nested
|
Below are MeSH descriptors whose meaning is more general than "Alternative Splicing".
Below are MeSH descriptors whose meaning is more specific than "Alternative Splicing".
This graph shows the total number of publications written about "Alternative Splicing" by people in this website by year, and whether "Alternative Splicing" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 0 | 1 | 1 |
1995 | 0 | 3 | 3 |
1996 | 1 | 2 | 3 |
1998 | 1 | 4 | 5 |
1999 | 2 | 3 | 5 |
2000 | 1 | 3 | 4 |
2001 | 0 | 1 | 1 |
2002 | 2 | 4 | 6 |
2003 | 0 | 3 | 3 |
2004 | 3 | 4 | 7 |
2005 | 2 | 2 | 4 |
2006 | 3 | 2 | 5 |
2007 | 3 | 1 | 4 |
2008 | 0 | 2 | 2 |
2009 | 1 | 0 | 1 |
2010 | 0 | 1 | 1 |
2011 | 0 | 1 | 1 |
2012 | 1 | 4 | 5 |
2013 | 2 | 0 | 2 |
2014 | 2 | 1 | 3 |
2015 | 1 | 0 | 1 |
2016 | 1 | 0 | 1 |
2017 | 1 | 0 | 1 |
2018 | 1 | 0 | 1 |
2019 | 0 | 2 | 2 |
2021 | 1 | 1 | 2 |
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Below are the most recent publications written about "Alternative Splicing" by people in Profiles.
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Alternative splicing of GluN1 gates glycine site-dependent nonionotropic signaling by NMDAR receptors. Proc Natl Acad Sci U S A. 2021 07 06; 118(27).
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Alternative Splicing Increases Sirtuin Gene Family Diversity and Modulates Their Subcellular Localization and Function. Int J Mol Sci. 2021 Jan 06; 22(2).
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Therapeutic targeting of RAS: New hope for drugging the "undruggable". Biochim Biophys Acta Mol Cell Res. 2020 02; 1867(2):118570.
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ATP6AP2 variant impairs CNS development and neuronal survival to cause fulminant neurodegeneration. J Clin Invest. 2019 04 15; 129(5):2145-2162.
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Any Way You Splice It: New Molecular Mechanisms of Cocaine-Induced Alternative Gene Expression. Biol Psychiatry. 2018 08 01; 84(3):162-164.
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A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression. Nat Cell Biol. 2017 Sep; 19(9):1105-1115.
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Complementary feature selection from alternative splicing events and gene expression for phenotype prediction. Bioinformatics. 2016 09 01; 32(17):i421-i429.
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A novel intracellular fibulin-1D variant binds to the cytoplasmic domain of integrin beta 1 subunit. Matrix Biol. 2015 Apr; 43:97-108.
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Identification and characterization of Dicer1e, a Dicer1 protein variant, in oral cancer cells. Mol Cancer. 2014 Aug 13; 13:190.
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Transcriptome analysis reveals differential splicing events in IPF lung tissue. PLoS One. 2014; 9(5):e97550.