Richard R. Drake

TitleEndowed Chair, Proteomics
InstitutionMedical University of South Carolina
DepartmentCell and Molecular Pharmacology and Experimental Therapeutics
AddressP.O. Box MSC 509
CRI 310
Children's Research Inst. - 173 Ashley Ave.
Phone843-792-4505
Fax843-792-2475
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    MALDI Imaging Mass Spectrometry and Glycoprotein Biomarkers of Cancer - In my laboratory, a variety of mass spectrometry tools within the MUSC Proteomics Center and Mass Spectrometry Facility are being applied to cancer diagnosis and prognosis research. Our emphasis is the application of these tools for analysis of clinically derived tissues, fluids and exosomes to develop proteomic-based or small molecule diagnostic assays, with a particular focus on glycosylation and its role in disease. A new state-of-the-art, translational MALDI Imaging Research Center has been created. The facility is anchored by a dual-source Bruker Daltonic 7T Solarix FTICR mass spectrometer, two Bruker AutoFlex III MALDI instruments, ImagePrep sprayer and nanoLiter Cool Wave spotter. These are complemented by a Thermo Orbitrap Elite mass spectrometer and an Agilent Triversa Nanomate with LESA-MS for direct analysis of post-translational modifications to proteins. This instrumentation is being applied to multiple translational cancer research projects within my laboratory, as well as collaborations within the department and throughout the NCI-designated Hollings Cancer Center . These projects combine the capabilities of the MUSC Proteomics Center with clinical research, lipidomic, biorepository and molecular pathology resources. The current cancers being targeted are primarily prostate, kidney and pancreatic cancers. The major research areas of the Drake laboratory are summarized as follows.

    MALDI Mass Spectrometry Tissue Imaging of Proteins, Glycans, Lipids and Drug Metabolites - MALDI imaging mass spectrometry (MALDI-IMS) is an established method used primarily to spatially profile proteins, lipids, drug and small molecule metabolites in tissues. Using the resources of the MUSC Proteomics Center and MALDI Imaging Research Center, our group has recently developed a glycobiology approach using on-tissue peptide N-glycanase F (PNGaseF) digestion to directly profile released N-linked glycans in their local microenvironment. Glycan profiling has been successfully used with fresh frozen and formalin-fixed tissues, and more recently, adapted to tissue microarrays representing prostate, lung, breast and pancreatic cancers. Using the dual-source Solarix FTICR MS instrumentation, another research emphasis is the development of methods to spatially profile bioactive ceramide, sphingosine and glycolipid specie distribution in tissues of clinical interest. A reference database of ceramide and glycosphingolipid masses for use in tissue imaging analysis has been created using tissues derived from lysosomal storage disease models (in collaboration with Jeffrey Medin, Univ. of Toronto and Yusuf Hannun, Stonybrook University), Drug uptake and metabolism in tissues derived from pre-clinical model systems is also ongoing, working in conjunction with researchers in the Hollings Cancer Center and the Developmental Cancer Therapeutics program. Using these approaches, a global snapshot of major cellular glycan, lipid and protein components is obtained, which includes their tissue localization and distribution, structure and relative concentration. The preparation and analysis workflows are readily linked to standard histopathology procedures. The method has been applied to multiple frozen tissues types, with emphasis on human renal, prostate and lung cancer tissues matched for tumor and non-tumor pieces, and tissues from different therapeutic mouse xenograft models of cancer. For clear cell renal cancer tissues, defining biomolecules that are unique to the non-tumor and tumor margin interface are being assessed. Current MALDI imaging analysis of these margin regions have identified multiple glycan, phospholipid, ceramide and protein species differentially expressed relative to non-tumor and tumor regions. Linking these biomolecular differences to known mediators of epithelial-to-mesenchymal transitions, pathology correlates and tumor metastasis are ongoing. The methods are also being applied to non-small cell lung carcinoma tissue, and a unique cohort of prostate tissues from an ongoing Vitamin D supplementation study prior to prostatectomy.

    Identification of Prostate and Lung Cancer Glycoprotein Biomarkers - Our overall research goal is the identification of glycoprotein biomarkers that will improve clinical decision-making in the detection and management of prostate and lung cancers. My laboratory has been part of a systemic effort to characterize and identify potential biomarker targets in proximal fluids of the prostate, including direct prostatic fluids obtained just prior to prostatectomy, and expressed prostatic secretions in urine obtained in the urology clinic following digital rectal exam. Our recent publications cumulatively describe the identification of over 1100 proteins identified in post-DRE expressed prostatic secretions in urine (EPS-urine) and prostatic fluids termed direct EPS obtained at the time of prostatectomy. Lastly, we have completed the proteome analysis of exosomes from pooled EPS samples from benign, indolent and aggressive cancers. These cumulative lists are near complete and available for rapid glycoprotein candidate screening in future studies. For lung cancers, NSCLC tissue and bronchoalveilar lavage samples were obtained from the Lung Cancer Biospecimen Resource Network and Dr. Chad Denlinger at MUSC New HCD-ETD workflows for direct analysis of EPS and bronchoalveolar lavage fluids, exosomes and tissue glycopeptides associated with disease status are in progress. Corresponding glycomic and lipidomic analyses of the same fluids and samples are also ongoing.

    A complementary biomarker discovery approach is being done using metabolic labeling with sugar-azides and alkyne-bead click chemistry to capture secreted and cell surface glycoproteins in human-derived prostate and lung cancer cell line models. A current emphasis is with cell lines associated with the epithelial-to-mesenchymal cell transition. The current workflow uses N-acetylgalactosamine (GalNAc-Az) or sialic acid (ManNAc-Az) analogs for metabolic labeling, cell lysis or concentration of conditioned media, and Click chemistry conjugation to alkyne beads. The bead-bound azide-modified glycoproteins can be extensively washed prior to direct protease digestion on the beads, which significantly reduces the background of non-specific, unmodified proteins identified at the mass spectrometry stage. Captured glycoproteins are digested directly from the beads and the resulting peptides analyzed on the Orbitrap Elite for protein identification and development of HCD-ETD glycopeptide analysis workflows. Bioinformatic pathway analysis is then done to link the proteins to molecular function and cancer biology. This biomarker selection step is being coupled with the EPS protein lists, and more recently bronchoalveolar lavage fluids, as part of a further biomarker candidate verification strategy.
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    Cancer/Sarcoma, Cancer

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ochoa-Rios S, Blaschke CRK, Wang M, Peterson KD, DelaCourt A, Grauzam SE, Lewin D, Angel P, Roberts LR, Drake R, Mehta AS. Analysis of N-linked Glycan Alterations in Tissue and Serum Reveals Promising Biomarkers for Intrahepatic Cholangiocarcinoma. Cancer Res Commun. 2023 Mar; 3(3):383-394. PMID: 36890858; PMCID: PMC9987250.
      Citations:    
    2. Butler W, McDowell C, Yang Q, He Y, Zhao Y, Hauck JS, Zhou Y, Zhang H, Armstrong AJ, George DJ, Drake R, Huang J. Rewiring of the N-Glycome with prostate cancer progression and therapy resistance. NPJ Precis Oncol. 2023 Feb 24; 7(1):22. PMID: 36828904; PMCID: PMC9958128.
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    3. Howard H, Clark P, Garrett M, Wise A, Kee M, Checketts J, Dhillon J, Drake R, Vassar M. A cross-sectional analysis of harms reporting in systematic reviews evaluating laminectomy. N Am Spine Soc J. 2023 Mar; 13:100198. PMID: 36691579; PMCID: PMC9860335.
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    4. Blaschke CRK, Hill EG, Mehta AS, Angel PM, Laronga C, Drake RR. Integrating age, BMI, and serum N-glycans detected by MALDI mass spectrometry to classify suspicious mammogram findings as benign lesions or breast cancer. Sci Rep. 2022 Dec 02; 12(1):20801. PMID: 36460712.
      Citations:    Fields:    Translation:Humans
    5. Clift CL, Saunders J, Drake RR, Angel PM. Perspectives on pediatric congenital aortic valve stenosis: Extracellular matrix proteins, post translational modifications, and proteomic strategies. Front Cardiovasc Med. 2022; 9:1024049. PMID: 36439995; PMCID: PMC9685993.
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    6. Babatunde OA, Pearce JL, Jefferson MS, Frey LJ, Angel PM, Drake RR, Allen CG, Lilly MB, Savage SJ, Hughes Halbert C. Racial Distribution of Neighborhood-Level Social Deprivation in a Retrospective Cohort of Prostate Cancer Survivors. Diseases. 2022 Oct 03; 10(4). PMID: 36278574; PMCID: PMC9589959.
      Citations: 1     
    7. Fan J, Liu J, Liu J, Angel PM, Drake RR, Wu Y, Fan H, Koutalos Y, Crosson CE. Sphingomyelinases in retinas and optic nerve heads: Effects of ocular hypertension and ischemia. Exp Eye Res. 2022 11; 224:109250. PMID: 36122624.
      Citations:    Fields:    Translation:HumansCells
    8. Young LEA, Conroy LR, Clarke HA, Hawkinson TR, Bolton KE, Sanders WC, Chang JE, Webb MB, Alilain WJ, Vander Kooi CW, Drake RR, Andres DA, Badgett TC, Wagner LM, Allison DB, Sun RC, Gentry MS. In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues. EMBO Mol Med. 2022 11 08; 14(11):e16029. PMID: 36059248; PMCID: PMC9641418.
      Citations: 2     Fields:    Translation:HumansAnimals
    9. DelaCourt AT, Liang H, Drake RR, Angel PM, Mehta AS, DelaCourt AT, Liang H, Drake RR, Angel PM, Mehta AS. Novel Combined Enzymatic Approach to Analyze Nonsialylated N-Linked Glycans through MALDI Imaging Mass Spectrometry. J Proteome Res. 2022 08 05; 21(8):1930-1938. PMID: 35766466.
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    10. Rujchanarong D, Scott D, Park Y, Brown S, Mehta AS, Drake R, Sandusky GE, Nakshatri H, Angel PM, Rujchanarong D, Scott D, Park Y, Brown S, Mehta AS, Drake R, Sandusky GE, Nakshatri H, Angel PM. Metabolic Links to Socioeconomic Stresses Uniquely Affecting Ancestry in Normal Breast Tissue at Risk for Breast Cancer. Front Oncol. 2022; 12:876651. PMID: 35832545; PMCID: PMC9273232.
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    11. Burnum-Johnson KE, Conrads TP, Drake RR, Herr AE, Iyengar R, Kelly RT, Lundberg E, MacCoss MJ, Naba A, Nolan GP, Pevzner PA, Rodland KD, Sechi S, Slavov N, Spraggins JM, Van Eyk JE, Vidal M, Vogel C, Walt DR, Kelleher NL, Burnum-Johnson KE, Conrads TP, Drake RR, Herr AE, Iyengar R, Kelly RT, Lundberg E, MacCoss MJ, Naba A, Nolan GP, Pevzner PA, Rodland KD, Sechi S, Slavov N, Spraggins JM, Van Eyk JE, Vidal M, Vogel C, Walt DR, Kelleher NL. New Views of Old Proteins: Clarifying the Enigmatic Proteome. Mol Cell Proteomics. 2022 07; 21(7):100254. PMID: 35654359; PMCID: PMC9256833.
      Citations: 1     Fields:    Translation:Humans
    12. Ochoa-Rios S, O'Connor IP, Kent LN, Clouse JM, Hadjiyannis Y, Koivisto C, Pecot T, Angel PM, Drake RR, Leone G, Mehta AS, Rockey DC, Ochoa-Rios S, O'Connor IP, Kent LN, Clouse JM, Hadjiyannis Y, Koivisto C, Pecot T, Angel PM, Drake RR, Leone G, Mehta AS, Rockey DC. Imaging Mass Spectrometry Reveals Alterations in N-Linked Glycosylation That Are Associated With Histopathological Changes in Nonalcoholic Steatohepatitis in Mouse and Human. Mol Cell Proteomics. 2022 05; 21(5):100225. PMID: 35331917; PMCID: PMC9092512.
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    13. Scott DA, Wang M, Grauzam S, Pippin S, Black A, Angel PM, Drake RR, Castellino S, Kono Y, Rockey DC, Mehta AS, Scott DA, Wang M, Grauzam S, Pippin S, Black A, Angel PM, Drake RR, Castellino S, Kono Y, Rockey DC, Mehta AS. GlycoFibroTyper: A Novel Method for the Glycan Analysis of IgG and the Development of a Biomarker Signature of Liver Fibrosis. Front Immunol. 2022; 13:797460. PMID: 35197973; PMCID: PMC8858972.
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    14. Troyer B, Rodgers J, Wolf BJ, Oates JC, Drake RR, Nowling TK, Troyer B, Rodgers J, Wolf BJ, Oates JC, Drake RR, Nowling TK. Glycosphingolipid Levels in Urine Extracellular Vesicles Enhance Prediction of Therapeutic Response in Lupus Nephritis. Metabolites. 2022 Feb 01; 12(2). PMID: 35208209; PMCID: PMC8876142.
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    15. Chandler CE, Anderton CR, Scott AJ, Charkoftaki G, Angel PM, Drake RR, Chandler CE, Anderton CR, Scott AJ, Charkoftaki G, Angel PM, Drake RR. Review of the Third Conference of the Imaging Mass Spectrometry Society (IMSS 3): Accounts of a Hybrid Virtual and In-Person Meeting and the State and Future of the Field. J Am Soc Mass Spectrom. 2022 Feb 02; 33(2):238-241. PMID: 35005981.
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    16. Klaver EJ, Dukes-Rimsky L, Kumar B, Xia ZJ, Dang T, Lehrman MA, Angel P, Drake RR, Freeze HH, Steet R, Flanagan-Steet H, Klaver EJ, Dukes-Rimsky L, Kumar B, Xia ZJ, Dang T, Lehrman MA, Angel P, Drake RR, Freeze HH, Steet R, Flanagan-Steet H. Protease-dependent defects in N-cadherin processing drive PMM2-CDG pathogenesis. JCI Insight. 2021 12 22; 6(24). PMID: 34784297; PMCID: PMC8783681.
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    17. Pace CL, Angel PM, Drake RR, Muddiman DC, Pace CL, Angel PM, Drake RR, Muddiman DC. Mass Spectrometry Imaging of N-Linked Glycans in a Formalin-Fixed Paraffin-Embedded Human Prostate by Infrared Matrix-Assisted Laser Desorption Electrospray Ionization. J Proteome Res. 2022 01 07; 21(1):243-249. PMID: 34860526; PMCID: PMC9944006.
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    18. McQuiston A, Scott D, Nord D, Langerude L, Pelaez A, Machuca T, Mehta A, Drake RR, Christie JD, Angel P, Atkinson C, McQuiston A, Scott D, Nord D, Langerude L, Pelaez A, Machuca T, Mehta A, Drake RR, Christie JD, Angel P, Atkinson C. Pro-inflammatory IgG1 N-glycan signature correlates with primary graft dysfunction onset in COPD patients. Transpl Immunol. 2022 04; 71:101491. PMID: 34767945.
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    19. Clift CL, McLaughlin S, Muñoz M, Suuronen EJ, Rotstein BH, Mehta AS, Drake RR, Alarcon EI, Angel PM, Clift CL, McLaughlin S, Mu?oz M, Suuronen EJ, Rotstein BH, Mehta AS, Drake RR, Alarcon EI, Angel PM. Evaluation of Therapeutic Collagen-Based Biomaterials in the Infarcted Mouse Heart by Extracellular Matrix Targeted MALDI Imaging Mass Spectrometry. J Am Soc Mass Spectrom. 2021 Dec 01; 32(12):2746-2754. PMID: 34713699; PMCID: PMC8639787.
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    20. Blaschke CRK, Hartig JP, Grimsley G, Liu L, Semmes OJ, Wu JD, Ippolito JE, Hughes-Halbert C, Nyalwidhe JO, Drake RR, Blaschke CRK, Hartig JP, Grimsley G, Liu L, Semmes OJ, Wu JD, Ippolito JE, Hughes-Halbert C, Nyalwidhe JO, Drake RR. Direct N-Glycosylation Profiling of Urine and Prostatic Fluid Glycoproteins and Extracellular Vesicles. Front Chem. 2021; 9:734280. PMID: 34646811; PMCID: PMC8503230.
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    21. Rujchanarong D, Lefler J, Saunders JE, Pippin S, Spruill L, Bethard JR, Ball LE, Mehta AS, Drake RR, Ostrowski MC, Angel PM, Rujchanarong D, Lefler J, Saunders JE, Pippin S, Spruill L, Bethard JR, Ball LE, Mehta AS, Drake RR, Ostrowski MC, Angel PM. Defining the Tumor Microenvironment by Integration of Immunohistochemistry and Extracellular Matrix Targeted Imaging Mass Spectrometry. Cancers (Basel). 2021 Sep 01; 13(17). PMID: 34503228; PMCID: PMC8430776.
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    22. McDowell CT, Lu X, Mehta AS, Angel PM, Drake RR, McDowell CT, Lu X, Mehta AS, Angel PM, Drake RR. Applications and continued evolution of glycan imaging mass spectrometry. Mass Spectrom Rev. 2023 03; 42(2):674-705. PMID: 34392557; PMCID: PMC8946722.
      Citations:    
    23. DelaCourt A, Black A, Angel P, Drake R, Hoshida Y, Singal A, Lewin D, Taouli B, Lewis S, Schwarz M, Fiel MI, Mehta AS, DelaCourt A, Black A, Angel P, Drake R, Hoshida Y, Singal A, Lewin D, Taouli B, Lewis S, Schwarz M, Fiel MI, Mehta AS. N-Glycosylation Patterns Correlate with Hepatocellular Carcinoma Genetic Subtypes. Mol Cancer Res. 2021 11; 19(11):1868-1877. PMID: 34380744; PMCID: PMC8802325.
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    24. Angel PM, Rujchanarong D, Pippin S, Spruill L, Drake R, Angel PM, Rujchanarong D, Pippin S, Spruill L, Drake R. Mass Spectrometry Imaging of Fibroblasts: Promise and Challenge. Expert Rev Proteomics. 2021 06; 18(6):423-436. PMID: 34129411; PMCID: PMC8717608.
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    25. Halbert CH, Jefferson M, Allen CG, Babatunde OA, Drake R, Angel P, Savage SJ, Frey L, Lilly M, Obi T, Obeid J, Halbert CH, Jefferson M, Allen CG, Babatunde OA, Drake R, Angel P, Savage SJ, Frey L, Lilly M, Obi T, Obeid J. Racial Differences in Patient Portal Activation and Research Enrollment Among Patients With Prostate Cancer. JCO Clin Cancer Inform. 2021 06; 5:768-774. PMID: 34328797; PMCID: PMC8812608.
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    26. Sun RC, Young LEA, Bruntz RC, Markussen KH, Zhou Z, Conroy LR, Hawkinson TR, Clarke HA, Stanback AE, Macedo JKA, Emanuelle S, Brewer MK, Rondon AL, Mestas A, Sanders WC, Mahalingan KK, Tang B, Chikwana VM, Segvich DM, Contreras CJ, Allenger EJ, Brainson CF, Johnson LA, Taylor RE, Armstrong DD, Shaffer R, Waechter CJ, Vander Kooi CW, DePaoli-Roach AA, Roach PJ, Hurley TD, Drake RR, Gentry MS, Sun RC, Young LEA, Bruntz RC, Markussen KH, Zhou Z, Conroy LR, Hawkinson TR, Clarke HA, Stanback AE, Macedo JKA, Emanuelle S, Brewer MK, Rondon AL, Mestas A, Sanders WC, Mahalingan KK, Tang B, Chikwana VM, Segvich DM, Contreras CJ, Allenger EJ, Brainson CF, Johnson LA, Taylor RE, Armstrong DD, Shaffer R, Waechter CJ, Vander Kooi CW, DePaoli-Roach AA, Roach PJ, Hurley TD, Drake RR, Gentry MS. Brain glycogen serves as a critical glucosamine cache required for protein glycosylation. Cell Metab. 2021 07 06; 33(7):1404-1417.e9. PMID: 34043942; PMCID: PMC8266748.
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    27. Rebelo AL, Gubinelli F, Roost P, Jan C, Brouillet E, Van Camp N, Drake RR, Saldova R, Pandit A, Rebelo AL, Gubinelli F, Roost P, Jan C, Brouillet E, Van Camp N, Drake RR, Saldova R, Pandit A. Complete spatial characterisation of N-glycosylation upon striatal neuroinflammation in the rodent brain. J Neuroinflammation. 2021 May 16; 18(1):116. PMID: 33993882; PMCID: PMC8127229.
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    28. Clift CL, Su YR, Bichell D, Jensen Smith HC, Bethard JR, Norris-Caneda K, Comte-Walters S, Ball LE, Hollingsworth MA, Mehta AS, Drake RR, Angel PM, Clift CL, Su YR, Bichell D, Jensen Smith HC, Bethard JR, Norris-Caneda K, Comte-Walters S, Ball LE, Hollingsworth MA, Mehta AS, Drake RR, Angel PM. Collagen fiber regulation in human pediatric aortic valve development and disease. Sci Rep. 2021 05 07; 11(1):9751. PMID: 33963260; PMCID: PMC8105334.
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    29. Blaschke CRK, McDowell CT, Black AP, Mehta AS, Angel PM, Drake RR, Blaschke CRK, McDowell CT, Black AP, Mehta AS, Angel PM, Drake RR. Glycan Imaging Mass Spectrometry: Progress in Developing Clinical Diagnostic Assays for Tissues, Biofluids, and Cells. Clin Lab Med. 2021 06; 41(2):247-266. PMID: 34020762; PMCID: PMC8862151.
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    30. Yu R, Longo J, van Leeuwen JE, Zhang C, Branchard E, Elbaz M, Cescon DW, Drake RR, Dennis JW, Penn LZ, Yu R, Longo J, van Leeuwen JE, Zhang C, Branchard E, Elbaz M, Cescon DW, Drake RR, Dennis JW, Penn LZ. Mevalonate Pathway Inhibition Slows Breast Cancer Metastasis via Reduced N-glycosylation Abundance and Branching. Cancer Res. 2021 05 15; 81(10):2625-2635. PMID: 33602786.
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    31. Angel PM, Drake RR, Park Y, Clift CL, West C, Berkhiser S, Hardiman G, Mehta AS, Bichell DP, Su YR, Angel PM, Drake RR, Park Y, Clift CL, West C, Berkhiser S, Hardiman G, Mehta AS, Bichell DP, Su YR. Spatial N-glycomics of the human aortic valve in development and pediatric endstage congenital aortic valve stenosis. J Mol Cell Cardiol. 2021 05; 154:6-20. PMID: 33516683; PMCID: PMC8722354.
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    32. Clift CL, Mehta A, Drake RR, Angel PM, Clift CL, Mehta A, Drake RR, Angel PM. Multiplexed Imaging Mass Spectrometry of Histological Staining, N-Glycan and Extracellular Matrix from One Tissue Section: A Tool for Fibrosis Research. Methods Mol Biol. 2021; 2350:313-329. PMID: 34331294.
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    33. West CA, Lu X, Grimsley G, Norris-Caneda K, Mehta AS, Angel PM, Drake RR, West CA, Lu X, Grimsley G, Norris-Caneda K, Mehta AS, Angel PM, Drake RR. Optimization of Multiple Glycosidase and Chemical Stabilization Strategies for N-Glycan Isomer Detection by Mass Spectrometry Imaging in Formalin-Fixed, Paraffin-Embedded Tissues. Methods Mol Biol. 2021; 2271:303-316. PMID: 33908016.
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    34. Angel PM, Mehta AS, Drake RR, Angel PM, Mehta AS, Drake RR. Array-Based N-Glycan Profiling of Cells in Culture. Methods Mol Biol. 2021; 2271:331-342. PMID: 33908018.
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    35. McDowell CT, Klamer Z, Hall J, West CA, Wisniewski L, Powers TW, Angel PM, Mehta AS, Lewin DN, Haab BB, Drake RR, McDowell CT, Klamer Z, Hall J, West CA, Wisniewski L, Powers TW, Angel PM, Mehta AS, Lewin DN, Haab BB, Drake RR. Imaging Mass Spectrometry and Lectin Analysis of N-Linked Glycans in Carbohydrate Antigen-Defined Pancreatic Cancer Tissues. Mol Cell Proteomics. 2021; 20:100012. PMID: 33581409; PMCID: PMC8724603.
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    36. Clift CL, Drake RR, Mehta A, Angel PM, Clift CL, Drake RR, Mehta A, Angel PM. Multiplexed imaging mass spectrometry of the extracellular matrix using serial enzyme digests from formalin-fixed paraffin-embedded tissue sections. Anal Bioanal Chem. 2021 Apr; 413(10):2709-2719. PMID: 33206215; PMCID: PMC8012227.
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    37. Gao C, Wisniewski L, Liu Y, Staal B, Beddows I, Plenker D, Aldakkak M, Hall J, Barnett D, Gouda MK, Allen P, Drake R, Zureikat A, Huang Y, Evans D, Singhi A, Brand RE, Tuveson DA, Tsai S, Haab BB, Gao C, Wisniewski L, Liu Y, Staal B, Beddows I, Plenker D, Aldakkak M, Hall J, Barnett D, Gouda MK, Allen P, Drake R, Zureikat A, Huang Y, Evans D, Singhi A, Brand RE, Tuveson DA, Tsai S, Haab BB. Detection of Chemotherapy-resistant Pancreatic Cancer Using a Glycan Biomarker, sTRA. Clin Cancer Res. 2021 01 01; 27(1):226-236. PMID: 33093149; PMCID: PMC7785673.
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    38. Bauer AG, Jefferson M, Nahhas GJ, Savage S, Drake R, Lilly M, Ambrose L, Caulder S, Mahvi D, Hughes Halbert C, Bauer AG, Jefferson M, Nahhas GJ, Savage S, Drake R, Lilly M, Ambrose L, Caulder S, Mahvi D, Hughes Halbert C. Financial toxicity and strain among men receiving prostate cancer care in an equal access healthcare system. Cancer Med. 2020 12; 9(23):8765-8771. PMID: 33070458; PMCID: PMC7724486.
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    39. Blaschke CRK, Black AP, Mehta AS, Angel PM, Drake RR, Blaschke CRK, Black AP, Mehta AS, Angel PM, Drake RR. Rapid N-Glycan Profiling of Serum and Plasma by a Novel Slide-Based Imaging Mass Spectrometry Workflow. J Am Soc Mass Spectrom. 2020 Dec 02; 31(12):2511-2520. PMID: 32809822; PMCID: PMC8880305.
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    40. Angel PM, Spruill L, Jefferson M, Bethard JR, Ball LE, Hughes-Halbert C, Drake RR, Angel PM, Spruill L, Jefferson M, Bethard JR, Ball LE, Hughes-Halbert C, Drake RR. Zonal regulation of collagen-type proteins and posttranslational modifications in prostatic benign and cancer tissues by imaging mass spectrometry. Prostate. 2020 09; 80(13):1071-1086. PMID: 32687633; PMCID: PMC7857723.
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    41. Murali P, Johnson BP, Lu Z, Climer L, Scott DA, Foulquier F, Oprea-Ilies G, Lupashin V, Drake RR, Abbott KL, Murali P, Johnson BP, Lu Z, Climer L, Scott DA, Foulquier F, Oprea-Ilies G, Lupashin V, Drake RR, Abbott KL. Novel role for the Golgi membrane protein TMEM165 in control of migration and invasion for breast carcinoma. Oncotarget. 2020 Jul 14; 11(28):2747-2762. PMID: 32733646; PMCID: PMC7367651.
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    42. West CA, Liang H, Drake RR, Mehta AS, West CA, Liang H, Drake RR, Mehta AS. New Enzymatic Approach to Distinguish Fucosylation Isomers of N-Linked Glycans in Tissues Using MALDI Imaging Mass Spectrometry. J Proteome Res. 2020 08 07; 19(8):2989-2996. PMID: 32441096; PMCID: PMC8908332.
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    43. Halbert CH, Jefferson MS, Drake R, Lilly M, Savage SJ, Nahhas GJ, Price ST, Loftley AE, Bauer A, Halbert CH, Jefferson MS, Drake R, Lilly M, Savage SJ, Nahhas GJ, Price ST, Loftley AE, Bauer A. Social and clinical determinants of physical activity in prostate cancer survivors. Support Care Cancer. 2021 Jan; 29(1):459-465. PMID: 32394247; PMCID: PMC7655513.
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    44. Jefferson M, Drake RR, Lilly M, Savage SJ, Tucker Price S, Hughes Halbert C, Jefferson M, Drake RR, Lilly M, Savage SJ, Tucker Price S, Hughes Halbert C. Co-morbidities in a Retrospective Cohort of Prostate Cancer Patients. Ethn Dis. 2020; 30(Suppl 1):185-192. PMID: 32269460; PMCID: PMC7138439.
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    45. Angel PM, Bruner E, Bethard J, Clift CL, Ball L, Drake RR, Feghali-Bostwick C, Angel PM, Bruner E, Bethard J, Clift CL, Ball L, Drake RR, Feghali-Bostwick C. Extracellular matrix alterations in low-grade lung adenocarcinoma compared with normal lung tissue by imaging mass spectrometry. J Mass Spectrom. 2020 Apr; 55(4):e4450. PMID: 31654589; PMCID: PMC7145762.
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    46. Miller C, Lawson A, Chung D, Gebregziabher M, Yeh E, Drake R, Hill E, Miller C, Lawson A, Chung D, Gebregziabher M, Yeh E, Drake R, Hill E. Automating a Process Convolution Approach to Account for Spatial Information in Imaging Mass Spectrometry Data. Spat Stat. 2020 Apr; 36. PMID: 32318329; PMCID: PMC7172386.
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    47. Drake RR, McDowell C, West C, David F, Powers TW, Nowling T, Bruner E, Mehta AS, Angel PM, Marlow LA, Tun HW, Copland JA, Drake RR, McDowell C, West C, David F, Powers TW, Nowling T, Bruner E, Mehta AS, Angel PM, Marlow LA, Tun HW, Copland JA. Defining the human kidney N-glycome in normal and cancer tissues using MALDI imaging mass spectrometry. J Mass Spectrom. 2020 Apr; 55(4):e4490. PMID: 31860772; PMCID: PMC7187388.
      Citations:    
    48. Black AP, Angel PM, Drake RR, Mehta AS, Black AP, Angel PM, Drake RR, Mehta AS. Antibody Panel Based N-Glycan Imaging for N-Glycoprotein Biomarker Discovery. Curr Protoc Protein Sci. 2019 12; 98(1):e99. PMID: 31721442; PMCID: PMC6859948.
      Citations:    
    49. Pati S, Angel P, Drake RR, Wagner JJ, Cummings BS, Pati S, Angel P, Drake RR, Wagner JJ, Cummings BS. Lipidomic changes in the rat hippocampus following cocaine conditioning, extinction, and reinstatement of drug-seeking. Brain Behav. 2019 12; 9(12):e01451. PMID: 31701674; PMCID: PMC6908860.
      Citations:    
    50. Orr RK, Hoehn JL, Col NF, Angel PM, Saunders J, Clift CL, White-Gilbertson S, Voelkel-Johnson C, Yeh E, Mehta A, Drake RR. A Rapid Array-Based Approach to N-Glycan Profiling of Cultured Cells. J Proteome Res. 2019 10 04; 18(10):3630-3639. PMID: 31535553; PMCID: PMC6827203.
      Citations:    
    51. Drake RR, Angel PM, Wu J, Pachynski RK, Ippolito JE, Drake RR, Angel PM, Wu J, Pachynski RK, Ippolito JE. How else can we approach prostate cancer biomarker discovery? Expert Rev Mol Diagn. 2020 02; 20(2):123-125. PMID: 31498690; PMCID: PMC7035159.
      Citations:    
    52. Scott DA, Drake RR, Scott DA, Drake RR. Glycosylation and its implications in breast cancer. Expert Rev Proteomics. 2019 08; 16(8):665-680. PMID: 31314995; PMCID: PMC6702063.
      Citations:    
    53. Black AP, Liang H, West CA, Wang M, Herrera HP, Haab BB, Angel PM, Drake RR, Mehta AS, Black AP, Liang H, West CA, Wang M, Herrera HP, Haab BB, Angel PM, Drake RR, Mehta AS. A Novel Mass Spectrometry Platform for Multiplexed N-Glycoprotein Biomarker Discovery from Patient Biofluids by Antibody Panel Based N-Glycan Imaging. Anal Chem. 2019 07 02; 91(13):8429-8435. PMID: 31177770; PMCID: PMC7017646.
      Citations:    
    54. Herrera H, Dilday T, Uber A, Scott D, Zambrano JN, Wang M, Angel PM, Mehta AS, Drake RR, Hill EG, Yeh ES, Herrera H, Dilday T, Uber A, Scott D, Zambrano JN, Wang M, Angel PM, Mehta AS, Drake RR, Hill EG, Yeh ES. Core-Fucosylated Tetra-Antennary N-Glycan Containing A Single N-Acetyllactosamine Branch Is Associated with Poor Survival Outcome in Breast Cancer. Int J Mol Sci. 2019 May 23; 20(10). PMID: 31126011; PMCID: PMC6566954.
      Citations:    
    55. Yang L, Kraemer M, Fang XF, Angel PM, Drake RR, Morris AJ, Smyth SS, Yang L, Kraemer M, Fang XF, Angel PM, Drake RR, Morris AJ, Smyth SS. LPA receptor 4 deficiency attenuates experimental atherosclerosis. J Lipid Res. 2019 05; 60(5):972-980. PMID: 30796085; PMCID: PMC6495174.
      Citations:    
    56. Turley D, Drake R, Killackey E, Yung AR, Turley D, Drake R, Killackey E, Yung AR. Perceived stress and psychosis: The effect of perceived stress on psychotic-like experiences in a community sample of adolescents. Early Interv Psychiatry. 2019 12; 13(6):1465-1469. PMID: 30712294.
      Citations:    
    57. Staal B, Liu Y, Barnett D, Hsueh P, He Z, Gao C, Partyka K, Hurd MW, Singhi AD, Drake RR, Huang Y, Maitra A, Brand RE, Haab BB, Staal B, Liu Y, Barnett D, Hsueh P, He Z, Gao C, Partyka K, Hurd MW, Singhi AD, Drake RR, Huang Y, Maitra A, Brand RE, Haab BB. The sTRA Plasma Biomarker: Blinded Validation of Improved Accuracy Over CA19-9 in Pancreatic Cancer Diagnosis. Clin Cancer Res. 2019 05 01; 25(9):2745-2754. PMID: 30617132; PMCID: PMC7246054.
      Citations:    
    58. Scott DA, Casadonte R, Cardinali B, Spruill L, Mehta AS, Carli F, Simone N, Kriegsmann M, Del Mastro L, Kriegsmann J, Drake RR, Scott DA, Casadonte R, Cardinali B, Spruill L, Mehta AS, Carli F, Simone N, Kriegsmann M, Del Mastro L, Kriegsmann J, Drake RR. Increases in Tumor N-Glycan Polylactosamines Associated with Advanced HER2-Positive and Triple-Negative Breast Cancer Tissues. Proteomics Clin Appl. 2019 01; 13(1):e1800014. PMID: 30592377; PMCID: PMC8913074.
      Citations:    
    59. Angel PM, Schwamborn K, Comte-Walters S, Clift CL, Ball LE, Mehta AS, Drake RR, Angel PM, Schwamborn K, Comte-Walters S, Clift CL, Ball LE, Mehta AS, Drake RR. Extracellular Matrix Imaging of Breast Tissue Pathologies by MALDI-Imaging Mass Spectrometry. Proteomics Clin Appl. 2019 01; 13(1):e1700152. PMID: 30251340; PMCID: PMC6730639.
      Citations:    
    60. West CA, Wang M, Herrera H, Liang H, Black A, Angel PM, Drake RR, Mehta AS, West CA, Wang M, Herrera H, Liang H, Black A, Angel PM, Drake RR, Mehta AS. N-Linked Glycan Branching and Fucosylation Are Increased Directly in Hcc Tissue As Determined through in Situ Glycan Imaging. J Proteome Res. 2018 10 05; 17(10):3454-3462. PMID: 30110170; PMCID: PMC6784322.
      Citations:    
    61. Angel PM, Norris-Caneda K, Drake RR, Angel PM, Norris-Caneda K, Drake RR. In Situ Imaging of Tryptic Peptides by MALDI Imaging Mass Spectrometry Using Fresh-Frozen or Formalin-Fixed, Paraffin-Embedded Tissue. Curr Protoc Protein Sci. 2018 11; 94(1):e65. PMID: 30114342; PMCID: PMC6205905.
      Citations:    
    62. Drake RR, Powers TW, Norris-Caneda K, Mehta AS, Angel PM, Drake RR, Powers TW, Norris-Caneda K, Mehta AS, Angel PM. In Situ Imaging of N-Glycans by MALDI Imaging Mass Spectrometry of Fresh or Formalin-Fixed Paraffin-Embedded Tissue. Curr Protoc Protein Sci. 2018 11; 94(1):e68. PMID: 30074304.
      Citations:    
    63. McDonald WS, Jones EE, Wojciak JM, Drake RR, Sabbadini RA, Harris NG, McDonald WS, Jones EE, Wojciak JM, Drake RR, Sabbadini RA, Harris NG. Matrix-Assisted Laser Desorption Ionization Mapping of Lysophosphatidic Acid Changes after Traumatic Brain Injury and the Relationship to Cellular Pathology. Am J Pathol. 2018 08; 188(8):1779-1793. PMID: 30037420; PMCID: PMC6099387.
      Citations:    
    64. Orr RK, Hoehn JL, Col NF, Mulligan JK, Patel K, Williamson T, Reaves N, Carroll W, Stephenson SE, Gao P, Drake RR, Neely BA, Tomlinson S, Schlosser RJ, Atkinson C. C3a receptor antagonism as a novel therapeutic target for chronic rhinosinusitis. Mucosal Immunol. 2018 09; 11(5):1375-1385. PMID: 29907871; PMCID: PMC6162114.
      Citations:    
    65. Helke K, Angel P, Lu P, Garrett-Mayer E, Ogretmen B, Drake R, Voelkel-Johnson C, Helke K, Angel P, Lu P, Garrett-Mayer E, Ogretmen B, Drake R, Voelkel-Johnson C. Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis. Sci Rep. 2018 01 26; 8(1):1627. PMID: 29374263; PMCID: PMC5786068.
      Citations:    
    66. Hasegawa T, Glavich GJ, Pahuski M, Short A, Semmes OJ, Yang L, Galkin V, Drake R, Esquela-Kerscher A, Hasegawa T, Glavich GJ, Pahuski M, Short A, Semmes OJ, Yang L, Galkin V, Drake R, Esquela-Kerscher A. Characterization and Evidence of the miR-888 Cluster as a Novel Cancer Network in Prostate. Mol Cancer Res. 2018 04; 16(4):669-681. PMID: 29330297; PMCID: PMC5882523.
      Citations:    
    67. Scott DA, Norris-Caneda K, Spruill L, Bruner E, Kono Y, Angel PM, Mehta AS, Drake RR, Scott DA, Norris-Caneda K, Spruill L, Bruner E, Kono Y, Angel PM, Mehta AS, Drake RR. Specific N-Linked Glycosylation Patterns in Areas of Necrosis in Tumor Tissues. Int J Mass Spectrom. 2019 Mar; 437:69-76. PMID: 31031563; PMCID: PMC6483403.
      Citations:    
    68. Mercer KE, Pulliam CF, Hennings L, Cleves MA, Jones EE, Drake RR, Ronis MJJ, Mercer KE, Pulliam CF, Hennings L, Cleves MA, Jones EE, Drake RR, Ronis MJJ. Diet Supplementation with Soy Protein Isolate, but Not the Isoflavone Genistein, Protects Against Alcohol-Induced Tumor Progression in DEN-Treated Male Mice. Adv Exp Med Biol. 2018; 1032:115-126. PMID: 30362095; PMCID: PMC6385589.
      Citations:    
    69. Drake RR, West CA, Mehta AS, Angel PM, Drake RR, West CA, Mehta AS, Angel PM. MALDI Mass Spectrometry Imaging of N-Linked Glycans in Tissues. Adv Exp Med Biol. 2018; 1104:59-76. PMID: 30484244.
      Citations:    
    70. Angel PM, Mehta A, Norris-Caneda K, Drake RR, Angel PM, Mehta A, Norris-Caneda K, Drake RR. MALDI Imaging Mass Spectrometry of N-glycans and Tryptic Peptides from the Same Formalin-Fixed, Paraffin-Embedded Tissue Section. Methods Mol Biol. 2018; 1788:225-241. PMID: 29058228; PMCID: PMC5997529.
      Citations:    
    71. Angel PM, Comte-Walters S, Ball LE, Talbot K, Mehta A, Brockbank KGM, Drake RR, Angel PM, Comte-Walters S, Ball LE, Talbot K, Mehta A, Brockbank KGM, Drake RR. Mapping Extracellular Matrix Proteins in Formalin-Fixed, Paraffin-Embedded Tissues by MALDI Imaging Mass Spectrometry. J Proteome Res. 2018 01 05; 17(1):635-646. PMID: 29161047; PMCID: PMC6637938.
      Citations:    
    72. Jones EE, Zhang W, Zhao X, Quiason C, Dale S, Shahidi-Latham S, Grabowski GA, Setchell KDR, Drake RR, Sun Y, Jones EE, Zhang W, Zhao X, Quiason C, Dale S, Shahidi-Latham S, Grabowski GA, Setchell KDR, Drake RR, Sun Y. Tissue Localization of Glycosphingolipid Accumulation in a Gaucher Disease Mouse Brain by LC-ESI-MS/MS and High-Resolution MALDI Imaging Mass Spectrometry. SLAS Discov. 2017 12; 22(10):1218-1228. PMID: 28714776.
      Citations:    
    73. Barnett D, Liu Y, Partyka K, Huang Y, Tang H, Hostetter G, Brand RE, Singhi AD, Drake RR, Haab BB, Barnett D, Liu Y, Partyka K, Huang Y, Tang H, Hostetter G, Brand RE, Singhi AD, Drake RR, Haab BB. The CA19-9 and Sialyl-TRA Antigens Define Separate Subpopulations of Pancreatic Cancer Cells. Sci Rep. 2017 06 22; 7(1):4020. PMID: 28642461; PMCID: PMC5481434.
      Citations:    
    74. Sikora J, Dworski S, Jones EE, Kamani MA, Micsenyi MC, Sawada T, Le Faouder P, Bertrand-Michel J, Dupuy A, Dunn CK, Xuan ICY, Casas J, Fabrias G, Hampson DR, Levade T, Drake RR, Medin JA, Walkley SU, Sikora J, Dworski S, Jones EE, Kamani MA, Micsenyi MC, Sawada T, Le Faouder P, Bertrand-Michel J, Dupuy A, Dunn CK, Xuan ICY, Casas J, Fabrias G, Hampson DR, Levade T, Drake RR, Medin JA, Walkley SU. Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities. Am J Pathol. 2017 Apr; 187(4):864-883. PMID: 28342444; PMCID: PMC5397689.
      Citations:    
    75. Angel PM, Baldwin HS, Gottlieb Sen D, Su YR, Mayer JE, Bichell D, Drake RR, Angel PM, Baldwin HS, Gottlieb Sen D, Su YR, Mayer JE, Bichell D, Drake RR. Advances in MALDI imaging mass spectrometry of proteins in cardiac tissue, including the heart valve. Biochim Biophys Acta Proteins Proteom. 2017 Jul; 1865(7):927-935. PMID: 28341601; PMCID: PMC5527275.
      Citations:    
    76. Drake RR, McDonnell LA, Drake RR, McDonnell LA. Preface. Adv Cancer Res. 2017; 134:xiii-xiv. PMID: 28110658.
      Citations:    
    77. McDonnell LA, Angel PM, Lou S, Drake RR, McDonnell LA, Angel PM, Lou S, Drake RR. Mass Spectrometry Imaging in Cancer Research: Future Perspectives. Adv Cancer Res. 2017; 134:283-290. PMID: 28110655.
      Citations:    
    78. Shao S, Neely BA, Kao TC, Eckhaus J, Bourgeois J, Brooks J, Jones EE, Drake RR, Zhu K, Shao S, Neely BA, Kao TC, Eckhaus J, Bourgeois J, Brooks J, Jones EE, Drake RR, Zhu K. Proteomic Profiling of Serial Prediagnostic Serum Samples for Early Detection of Colon Cancer in the U.S. Military. Cancer Epidemiol Biomarkers Prev. 2017 05; 26(5):711-718. PMID: 28003179; PMCID: PMC5413427.
      Citations:    
    79. Drake RR, Powers TW, Jones EE, Bruner E, Mehta AS, Angel PM, Drake RR, Powers TW, Jones EE, Bruner E, Mehta AS, Angel PM. MALDI Mass Spectrometry Imaging of N-Linked Glycans in Cancer Tissues. Adv Cancer Res. 2017; 134:85-116. PMID: 28110657; PMCID: PMC6020705.
      Citations:    
    80. Reatini BS, Ensink E, Liau B, Sinha JY, Powers TW, Partyka K, Bern M, Brand RE, Rudd PM, Kletter D, Drake R, Haab BB, Reatini BS, Ensink E, Liau B, Sinha JY, Powers TW, Partyka K, Bern M, Brand RE, Rudd PM, Kletter D, Drake R, Haab BB. Characterizing Protein Glycosylation through On-Chip Glycan Modification and Probing. Anal Chem. 2016 12 06; 88(23):11584-11592. PMID: 27809484; PMCID: PMC5290727.
      Citations:    
    81. Heijs B, Holst S, Briaire-de Bruijn IH, van Pelt GW, de Ru AH, van Veelen PA, Drake RR, Mehta AS, Mesker WE, Tollenaar RA, Bovée JV, Wuhrer M, McDonnell LA, Heijs B, Holst S, Briaire-de Bruijn IH, van Pelt GW, de Ru AH, van Veelen PA, Drake RR, Mehta AS, Mesker WE, Tollenaar RA, Bov?e JV, Wuhrer M, McDonnell LA. Multimodal Mass Spectrometry Imaging of N-Glycans and Proteins from the Same Tissue Section. Anal Chem. 2016 08 02; 88(15):7745-53. PMID: 27373711.
      Citations:    
    82. Kim Y, Jeon J, Mejia S, Yao CQ, Ignatchenko V, Nyalwidhe JO, Gramolini AO, Lance RS, Troyer DA, Drake RR, Boutros PC, Semmes OJ, Kislinger T, Kim Y, Jeon J, Mejia S, Yao CQ, Ignatchenko V, Nyalwidhe JO, Gramolini AO, Lance RS, Troyer DA, Drake RR, Boutros PC, Semmes OJ, Kislinger T. Targeted proteomics identifies liquid-biopsy signatures for extracapsular prostate cancer. Nat Commun. 2016 06 28; 7:11906. PMID: 27350604; PMCID: PMC4931234.
      Citations:    
    83. Holst S, Heijs B, de Haan N, van Zeijl RJ, Briaire-de Bruijn IH, van Pelt GW, Mehta AS, Angel PM, Mesker WE, Tollenaar RA, Drake RR, Bovée JV, McDonnell LA, Wuhrer M, Holst S, Heijs B, de Haan N, van Zeijl RJ, Briaire-de Bruijn IH, van Pelt GW, Mehta AS, Angel PM, Mesker WE, Tollenaar RA, Drake RR, Bov?e JV, McDonnell LA, Wuhrer M. Linkage-Specific in Situ Sialic Acid Derivatization for N-Glycan Mass Spectrometry Imaging of Formalin-Fixed Paraffin-Embedded Tissues. Anal Chem. 2016 06 07; 88(11):5904-13. PMID: 27145236.
      Citations:    
    84. Neely BA, Wilkins CE, Marlow LA, Malyarenko D, Kim Y, Ignatchenko A, Sasinowska H, Sasinowski M, Nyalwidhe JO, Kislinger T, Copland JA, Drake RR, Neely BA, Wilkins CE, Marlow LA, Malyarenko D, Kim Y, Ignatchenko A, Sasinowska H, Sasinowski M, Nyalwidhe JO, Kislinger T, Copland JA, Drake RR. Proteotranscriptomic Analysis Reveals Stage Specific Changes in the Molecular Landscape of Clear-Cell Renal Cell Carcinoma. PLoS One. 2016; 11(4):e0154074. PMID: 27128972; PMCID: PMC4851420.
      Citations:    
    85. Mercer KE, Pulliam C, Hennings L, Lai K, Cleves M, Jones E, Drake RR, Ronis M, Mercer KE, Pulliam C, Hennings L, Lai K, Cleves M, Jones E, Drake RR, Ronis M. Soy Protein Isolate Protects Against Ethanol-Mediated Tumor Progression in Diethylnitrosamine-Treated Male Mice. Cancer Prev Res (Phila). 2016 06; 9(6):466-75. PMID: 27006377; PMCID: PMC4891267.
      Citations:    
    86. Vaughn AA, Drake RR, Haydock S, Vaughn AA, Drake RR, Haydock S. College student mental health and quality of workplace relationships. J Am Coll Health. 2016; 64(1):26-37. PMID: 26151646.
      Citations:    
    87. Yang L, Dutta SM, Troyer DA, Lin JB, Lance RA, Nyalwidhe JO, Drake RR, Semmes OJ, Yang L, Dutta SM, Troyer DA, Lin JB, Lance RA, Nyalwidhe JO, Drake RR, Semmes OJ. Dysregulated expression of cell surface glycoprotein CDCP1 in prostate cancer. Oncotarget. 2015 Dec 22; 6(41):43743-58. PMID: 26497208; PMCID: PMC4791263.
      Citations:    
    88. Sundararaj KP, Thiyagarajan T, Molano I, Basher F, Powers TW, Drake RR, Nowling TK, Sundararaj KP, Thiyagarajan T, Molano I, Basher F, Powers TW, Drake RR, Nowling TK. FLI1 Levels Impact CXCR3 Expression and Renal Infiltration of T Cells and Renal Glycosphingolipid Metabolism in the MRL/lpr Lupus Mouse Strain. J Immunol. 2015 Dec 15; 195(12):5551-60. PMID: 26538397; PMCID: PMC4670796.
      Citations:    
    89. Jones EE, Gao P, Smith CD, Norris JS, Drake RR, Jones EE, Gao P, Smith CD, Norris JS, Drake RR. Tissue biomarkers of drug efficacy: case studies using a MALDI-MSI workflow. Bioanalysis. 2015; 7(20):2611-9. PMID: 26505686.
      Citations:    
    90. Venant H, Rahmaniyan M, Jones EE, Lu P, Lilly MB, Garrett-Mayer E, Drake RR, Kraveka JM, Smith CD, Voelkel-Johnson C, Venant H, Rahmaniyan M, Jones EE, Lu P, Lilly MB, Garrett-Mayer E, Drake RR, Kraveka JM, Smith CD, Voelkel-Johnson C. The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo. Mol Cancer Ther. 2015 Dec; 14(12):2744-52. PMID: 26494858; PMCID: PMC4674301.
      Citations:    
    91. Powers TW, Holst S, Wuhrer M, Mehta AS, Drake RR, Powers TW, Holst S, Wuhrer M, Mehta AS, Drake RR. Two-Dimensional N-Glycan Distribution Mapping of Hepatocellular Carcinoma Tissues by MALDI-Imaging Mass Spectrometry. Biomolecules. 2015 Oct 15; 5(4):2554-72. PMID: 26501333; PMCID: PMC4693247.
      Citations:    
    92. Pallitto P, Ablonczy Z, Jones EE, Drake RR, Koutalos Y, Crouch RK, Donello J, Herrmann J, Pallitto P, Ablonczy Z, Jones EE, Drake RR, Koutalos Y, Crouch RK, Donello J, Herrmann J. A2E and lipofuscin distributions in macaque retinal pigment epithelium are similar to human. Photochem Photobiol Sci. 2015 Oct; 14(10):1888-95. PMID: 26223373; PMCID: PMC4589511.
      Citations:    
    93. Drake RR, Jones EE, Powers TW, Nyalwidhe JO, Drake RR, Jones EE, Powers TW, Nyalwidhe JO. Altered glycosylation in prostate cancer. Adv Cancer Res. 2015; 126:345-82. PMID: 25727153.
      Citations:    
    94. Drake RR, Drake RR. Glycosylation and cancer: moving glycomics to the forefront. Adv Cancer Res. 2015; 126:1-10. PMID: 25727144.
      Citations:    
    95. Drake RR, Ball L, Drake RR, Ball L. Unique to this volume is the subsequent focus of individual chapters on what is known about glycosylation in relation to specific organ sites of cancer. Preface. Adv Cancer Res. 2015; 126:xiii-xiv. PMID: 25727154.
      Citations:    
    96. Simpkins F, Drake R, Escobar PF, Nutter B, Rasool N, Rose PG, Simpkins F, Drake R, Escobar PF, Nutter B, Rasool N, Rose PG. A phase II trial of paclitaxel, carboplatin, and bevacizumab in advanced and recurrent endometrial carcinoma (EMCA). Gynecol Oncol. 2015 Feb; 136(2):240-5. PMID: 25485782.
      Citations:    
    97. Rachidi S, Sun S, Wu BX, Jones E, Drake RR, Ogretmen B, Cowart LA, Clarke CJ, Hannun YA, Chiosis G, Liu B, Li Z, Rachidi S, Sun S, Wu BX, Jones E, Drake RR, Ogretmen B, Cowart LA, Clarke CJ, Hannun YA, Chiosis G, Liu B, Li Z. Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis. J Hepatol. 2015 Apr; 62(4):879-88. PMID: 25463537; PMCID: PMC4369194.
      Citations:    
    98. Nowling TK, Mather AR, Thiyagarajan T, Hernández-Corbacho MJ, Powers TW, Jones EE, Snider AJ, Oates JC, Drake RR, Siskind LJ, Nowling TK, Mather AR, Thiyagarajan T, Hern?ndez-Corbacho MJ, Powers TW, Jones EE, Snider AJ, Oates JC, Drake RR, Siskind LJ. Renal glycosphingolipid metabolism is dysfunctional in lupus nephritis. J Am Soc Nephrol. 2015 Jun; 26(6):1402-13. PMID: 25270066; PMCID: PMC4446878.
      Citations:    
    99. Zhang J, Ye ZW, Gao P, Reyes L, Jones EE, Branham-O'Connor M, Blumer JB, Drake RR, Manevich Y, Townsend DM, Tew KD, Zhang J, Ye ZW, Gao P, Reyes L, Jones EE, Branham-O'Connor M, Blumer JB, Drake RR, Manevich Y, Townsend DM, Tew KD. Glutathione S-transferase P influences redox and migration pathways in bone marrow. PLoS One. 2014; 9(9):e107478. PMID: 25216273; PMCID: PMC4162606.
      Citations:    
    100. Powers TW, Neely BA, Shao Y, Tang H, Troyer DA, Mehta AS, Haab BB, Drake RR, Powers TW, Neely BA, Shao Y, Tang H, Troyer DA, Mehta AS, Haab BB, Drake RR. MALDI imaging mass spectrometry profiling of N-glycans in formalin-fixed paraffin embedded clinical tissue blocks and tissue microarrays. PLoS One. 2014; 9(9):e106255. PMID: 25184632; PMCID: PMC4153616.
      Citations:    
    101. Jones EE, Dworski S, Canals D, Casas J, Fabrias G, Schoenling D, Levade T, Denlinger C, Hannun YA, Medin JA, Drake RR, Jones EE, Dworski S, Canals D, Casas J, Fabrias G, Schoenling D, Levade T, Denlinger C, Hannun YA, Medin JA, Drake RR. On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging. Anal Chem. 2014 Aug 19; 86(16):8303-11. PMID: 25072097; PMCID: PMC4139181.
      Citations:    
    102. Von Roemeling CA, Marlow LA, Radisky DC, Rohl A, Larsen HE, Wei J, Sasinowska H, Zhu H, Drake R, Sasinowski M, Tun HW, Copland JA, Von Roemeling CA, Marlow LA, Radisky DC, Rohl A, Larsen HE, Wei J, Sasinowska H, Zhu H, Drake R, Sasinowski M, Tun HW, Copland JA. Functional genomics identifies novel genes essential for clear cell renal cell carcinoma tumor cell proliferation and migration. Oncotarget. 2014 Jul 30; 5(14):5320-34. PMID: 24979721; PMCID: PMC4170622.
      Citations:    
    103. Medarova Z, Ghosh SK, Vangel M, Drake R, Moore A, Medarova Z, Ghosh SK, Vangel M, Drake R, Moore A. Risk stratification of prostate cancer patients based on EPS-urine zinc content. Am J Cancer Res. 2014; 4(4):385-93. PMID: 25057441; PMCID: PMC4106656.
      Citations:    
    104. Baatz JE, Newton DA, Riemer EC, Denlinger CE, Jones EE, Drake RR, Spyropoulos DD, Baatz JE, Newton DA, Riemer EC, Denlinger CE, Jones EE, Drake RR, Spyropoulos DD. Cryopreservation of viable human lung tissue for versatile post-thaw analyses and culture. In Vivo. 2014 Jul-Aug; 28(4):411-23. PMID: 24982205; PMCID: PMC5937261.
      Citations:    
    105. McDonald JA, Vadaparampil S, Bowen D, Magwood G, Obeid JS, Jefferson M, Drake R, Gebregziabher M, Hughes Halbert C, McDonald JA, Vadaparampil S, Bowen D, Magwood G, Obeid JS, Jefferson M, Drake R, Gebregziabher M, Hughes Halbert C. Intentions to donate to a biobank in a national sample of African Americans. Public Health Genomics. 2014; 17(3):173-82. PMID: 24942180; PMCID: PMC5019027.
      Citations:    
    106. Jones EE, Powers TW, Neely BA, Cazares LH, Troyer DA, Parker AS, Drake RR, Jones EE, Powers TW, Neely BA, Cazares LH, Troyer DA, Parker AS, Drake RR. MALDI imaging mass spectrometry profiling of proteins and lipids in clear cell renal cell carcinoma. Proteomics. 2014 Apr; 14(7-8):924-35. PMID: 24497498; PMCID: PMC4331029.
      Citations:    
    107. Drake RR, Kislinger T, Drake RR, Kislinger T. The proteomics of prostate cancer exosomes. Expert Rev Proteomics. 2014 Apr; 11(2):167-77. PMID: 24564711.
      Citations:    
    108. Gilleen J, Michalopoulou PG, Reichenberg A, Drake R, Wykes T, Lewis SW, Kapur S, Gilleen J, Michalopoulou PG, Reichenberg A, Drake R, Wykes T, Lewis SW, Kapur S. Modafinil combined with cognitive training is associated with improved learning in healthy volunteers--a randomised controlled trial. Eur Neuropsychopharmacol. 2014 Apr; 24(4):529-39. PMID: 24485800.
      Citations:    
    109. Lewis H, Lance R, Troyer D, Beydoun H, Hadley M, Orians J, Benzine T, Madric K, Semmes OJ, Drake R, Esquela-Kerscher A, Lewis H, Lance R, Troyer D, Beydoun H, Hadley M, Orians J, Benzine T, Madric K, Semmes OJ, Drake R, Esquela-Kerscher A. miR-888 is an expressed prostatic secretions-derived microRNA that promotes prostate cell growth and migration. Cell Cycle. 2014; 13(2):227-39. PMID: 24200968; PMCID: PMC3906240.
      Citations:    
    110. Powers TW, Jones EE, Betesh LR, Romano PR, Gao P, Copland JA, Mehta AS, Drake RR, Powers TW, Jones EE, Betesh LR, Romano PR, Gao P, Copland JA, Mehta AS, Drake RR. Matrix assisted laser desorption ionization imaging mass spectrometry workflow for spatial profiling analysis of N-linked glycan expression in tissues. Anal Chem. 2013 Oct 15; 85(20):9799-806. PMID: 24050758; PMCID: PMC3969840.
      Citations:    
    111. Cheng JC, Bai A, Beckham TH, Marrison ST, Yount CL, Young K, Lu P, Bartlett AM, Wu BX, Keane BJ, Armeson KE, Marshall DT, Keane TE, Smith MT, Jones EE, Drake RR, Bielawska A, Norris JS, Liu X, Cheng JC, Bai A, Beckham TH, Marrison ST, Yount CL, Young K, Lu P, Bartlett AM, Wu BX, Keane BJ, Armeson KE, Marshall DT, Keane TE, Smith MT, Jones EE, Drake RR, Bielawska A, Norris JS, Liu X. Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse. J Clin Invest. 2013 Oct; 123(10):4344-58. PMID: 24091326; PMCID: PMC3784522.
      Citations:    
    112. Nyalwidhe JO, Betesh LR, Powers TW, Jones EE, White KY, Burch TC, Brooks J, Watson MT, Lance RS, Troyer DA, Semmes OJ, Mehta A, Drake RR, Nyalwidhe JO, Betesh LR, Powers TW, Jones EE, White KY, Burch TC, Brooks J, Watson MT, Lance RS, Troyer DA, Semmes OJ, Mehta A, Drake RR. Increased bisecting N-acetylglucosamine and decreased branched chain glycans of N-linked glycoproteins in expressed prostatic secretions associated with prostate cancer progression. Proteomics Clin Appl. 2013 Oct; 7(9-10):677-89. PMID: 23775902; PMCID: PMC3969874.
      Citations:    
    113. Leymarie N, Griffin PJ, Jonscher K, Kolarich D, Orlando R, McComb M, Zaia J, Aguilan J, Alley WR, Altmann F, Ball LE, Basumallick L, Bazemore-Walker CR, Behnken H, Blank MA, Brown KJ, Bunz SC, Cairo CW, Cipollo JF, Daneshfar R, Desaire H, Drake RR, Go EP, Goldman R, Gruber C, Halim A, Hathout Y, Hensbergen PJ, Horn DM, Hurum D, Jabs W, Larson G, Ly M, Mann BF, Marx K, Mechref Y, Meyer B, Möginger U, Neusüß C, Nilsson J, Novotny MV, Nyalwidhe JO, Packer NH, Pompach P, Reiz B, Resemann A, Rohrer JS, Ruthenbeck A, Sanda M, Schulz JM, Schweiger-Hufnagel U, Sihlbom C, Song E, Staples GO, Suckau D, Tang H, Thaysen-Andersen M, Viner RI, An Y, Valmu L, Wada Y, Watson M, Windwarder M, Whittal R, Wuhrer M, Zhu Y, Zou C, Leymarie N, Griffin PJ, Jonscher K, Kolarich D, Orlando R, McComb M, Zaia J, Aguilan J, Alley WR, Altmann F, Ball LE, Basumallick L, Bazemore-Walker CR, Behnken H, Blank MA, Brown KJ, Bunz SC, Cairo CW, Cipollo JF, Daneshfar R, Desaire H, Drake RR, Go EP, Goldman R, Gruber C, Halim A, Hathout Y, Hensbergen PJ, Horn DM, Hurum D, Jabs W, Larson G, Ly M, Mann BF, Marx K, Mechref Y, Meyer B, M?ginger U, Neus?? C, Nilsson J, Novotny MV, Nyalwidhe JO, Packer NH, Pompach P, Reiz B, Resemann A, Rohrer JS, Ruthenbeck A, Sanda M, Schulz JM, Schweiger-Hufnagel U, Sihlbom C, Song E, Staples GO, Suckau D, Tang H, Thaysen-Andersen M, Viner RI, An Y, Valmu L, Wada Y, Watson M, Windwarder M, Whittal R, Wuhrer M, Zhu Y, Zou C. Interlaboratory study on differential analysis of protein glycosylation by mass spectrometry: the ABRF glycoprotein research multi-institutional study 2012. Mol Cell Proteomics. 2013 Oct; 12(10):2935-51. PMID: 23764502; PMCID: PMC3790302.
      Citations:    
    114. Roper SM, Zemskova M, Neely BA, Martin A, Gao P, Jones EE, Kraft AS, Drake RR, Roper SM, Zemskova M, Neely BA, Martin A, Gao P, Jones EE, Kraft AS, Drake RR. Targeted glycoprotein enrichment and identification in stromal cell secretomes using azido sugar metabolic labeling. Proteomics Clin Appl. 2013 Jun; 7(5-6):367-71. PMID: 23687070; PMCID: PMC4331031.
      Citations:    
    115. Principe S, Jones EE, Kim Y, Sinha A, Nyalwidhe JO, Brooks J, Semmes OJ, Troyer DA, Lance RS, Kislinger T, Drake RR, Principe S, Jones EE, Kim Y, Sinha A, Nyalwidhe JO, Brooks J, Semmes OJ, Troyer DA, Lance RS, Kislinger T, Drake RR. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics. 2013 May; 13(10-11):1667-1671. PMID: 23533145; PMCID: PMC3773505.
      Citations:    
    116. Beckham TH, Lu P, Jones EE, Marrison T, Lewis CS, Cheng JC, Ramshesh VK, Beeson G, Beeson CC, Drake RR, Bielawska A, Bielawski J, Szulc ZM, Ogretmen B, Norris JS, Liu X, Beckham TH, Lu P, Jones EE, Marrison T, Lewis CS, Cheng JC, Ramshesh VK, Beeson G, Beeson CC, Drake RR, Bielawska A, Bielawski J, Szulc ZM, Ogretmen B, Norris JS, Liu X. LCL124, a cationic analog of ceramide, selectively induces pancreatic cancer cell death by accumulating in mitochondria. J Pharmacol Exp Ther. 2013 Jan; 344(1):167-78. PMID: 23086228; PMCID: PMC3533418.
      Citations:    
    117. Kim Y, Ignatchenko V, Yao CQ, Kalatskaya I, Nyalwidhe JO, Lance RS, Gramolini AO, Troyer DA, Stein LD, Boutros PC, Medin JA, Semmes OJ, Drake RR, Kislinger T, Kim Y, Ignatchenko V, Yao CQ, Kalatskaya I, Nyalwidhe JO, Lance RS, Gramolini AO, Troyer DA, Stein LD, Boutros PC, Medin JA, Semmes OJ, Drake RR, Kislinger T. Identification of differentially expressed proteins in direct expressed prostatic secretions of men with organ-confined versus extracapsular prostate cancer. Mol Cell Proteomics. 2012 Dec; 11(12):1870-84. PMID: 22986220; PMCID: PMC3518113.
      Citations:    
    118. Downing J, Birtar D, Chambers L, Gelb B, Drake R, Kiman R, Downing J, Birtar D, Chambers L, Gelb B, Drake R, Kiman R. Children's palliative care: a global concern. Int J Palliat Nurs. 2012 Mar; 18(3):109-14. PMID: 22584310.
      Citations:    
    119. Principe S, Kim Y, Fontana S, Ignatchenko V, Nyalwidhe JO, Lance RS, Troyer DA, Alessandro R, Semmes OJ, Kislinger T, Drake RR, Medin JA, Principe S, Kim Y, Fontana S, Ignatchenko V, Nyalwidhe JO, Lance RS, Troyer DA, Alessandro R, Semmes OJ, Kislinger T, Drake RR, Medin JA. Identification of prostate-enriched proteins by in-depth proteomic analyses of expressed prostatic secretions in urine. J Proteome Res. 2012 Apr 06; 11(4):2386-96. PMID: 22339264; PMCID: PMC3642074.
      Citations:    
    120. Orr RK, Hoehn JL, Col NF, Hair PS, Wagner SM, Friederich PT, Drake RR, Nyalwidhe JO, Cunnion KM. Complement regulator C4BP binds to Staphylococcus aureus and decreases opsonization. Mol Immunol. 2012 Apr; 50(4):253-61. PMID: 22333221.
      Citations:    
    121. Boggs SR, Cazares LH, Drake R, Boggs SR, Cazares LH, Drake R. Characterization of a Staphylococcus aureus USA300 protein signature using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. J Med Microbiol. 2012 May; 61(Pt 5):640-644. PMID: 22322338.
      Citations:    
    122. Drake RR, Boggs SR, Drake SK, Drake RR, Boggs SR, Drake SK. Pathogen identification using mass spectrometry in the clinical microbiology laboratory. J Mass Spectrom. 2011 Dec; 46(12):1223-32. PMID: 22223412.
      Citations:    
    123. Drake RR, Boggs SR, Drake SK, Drake RR, Boggs SR, Drake SK. Pathogen identifi cation using mass spectrometry in the clinical microbiology laboratory. J Mass Spectrom. 2011 Dec; 46(12):1. PMID: 22223408.
      Citations:    
    124. Lance RS, Drake RR, Troyer DA, Lance RS, Drake RR, Troyer DA. Multiple recognition assay reveals prostasomes as promising plasma biomarkers for prostate cancer. Expert Rev Anticancer Ther. 2011 Sep; 11(9):1341-3. PMID: 21929308.
      Citations:    
    125. Dai C, Cazares LH, Wang L, Chu Y, Wang SL, Troyer DA, Semmes OJ, Drake RR, Wang B, Dai C, Cazares LH, Wang L, Chu Y, Wang SL, Troyer DA, Semmes OJ, Drake RR, Wang B. Using boronolectin in MALDI-MS imaging for the histological analysis of cancer tissue expressing the sialyl Lewis X antigen. Chem Commun (Camb). 2011 Oct 07; 47(37):10338-40. PMID: 21853197.
      Citations:    
    126. Cazares LH, Troyer DA, Wang B, Drake RR, Semmes OJ, Cazares LH, Troyer DA, Wang B, Drake RR, Semmes OJ. MALDI tissue imaging: from biomarker discovery to clinical applications. Anal Bioanal Chem. 2011 Jul; 401(1):17-27. PMID: 21541816; PMCID: PMC6037172.
      Citations:    
    127. Yang L, Nyalwidhe JO, Guo S, Drake RR, Semmes OJ, Yang L, Nyalwidhe JO, Guo S, Drake RR, Semmes OJ. Targeted identification of metastasis-associated cell-surface sialoglycoproteins in prostate cancer. Mol Cell Proteomics. 2011 Jun; 10(6):M110.007294. PMID: 21447706; PMCID: PMC3108840.
      Citations:    
    128. Drake RR, Cazares LH, Jones EE, Fuller TW, Semmes OJ, Laronga C, Drake RR, Cazares LH, Jones EE, Fuller TW, Semmes OJ, Laronga C. Challenges to developing proteomic-based breast cancer diagnostics. OMICS. 2011 May; 15(5):251-9. PMID: 21332380; PMCID: PMC3128487.
      Citations:    
    129. Gatlin CL, White KY, Tracy MB, Wilkins CE, Semmes OJ, Nyalwidhe JO, Drake RR, Malyarenko DI, Gatlin CL, White KY, Tracy MB, Wilkins CE, Semmes OJ, Nyalwidhe JO, Drake RR, Malyarenko DI. Enhancement in MALDI-TOF MS analysis of the low molecular weight human serum proteome. J Mass Spectrom. 2011 Jan; 46(1):85-9. PMID: 21190259; PMCID: PMC3076319.
      Citations:    
    130. Reniers RL, Corcoran R, Drake R, Shryane NM, Völlm BA, Reniers RL, Corcoran R, Drake R, Shryane NM, V?llm BA. The QCAE: a Questionnaire of Cognitive and Affective Empathy. J Pers Assess. 2011 Jan; 93(1):84-95. PMID: 21184334.
      Citations:    
    131. Drake RR, Elschenbroich S, Lopez-Perez O, Kim Y, Ignatchenko V, Ignatchenko A, Nyalwidhe JO, Basu G, Wilkins CE, Gjurich B, Lance RS, Semmes OJ, Medin JA, Kislinger T, Drake RR, Elschenbroich S, Lopez-Perez O, Kim Y, Ignatchenko V, Ignatchenko A, Nyalwidhe JO, Basu G, Wilkins CE, Gjurich B, Lance RS, Semmes OJ, Medin JA, Kislinger T. In-depth proteomic analyses of direct expressed prostatic secretions. J Proteome Res. 2010 May 07; 9(5):2109-16. PMID: 20334419; PMCID: PMC2869496.
      Citations:    
    132. Drake RR, Drake RR. Glyco-Forum section Obituary: Alan D. Elbein (1933-2009). Glycobiology. 2010 Jan; 20(4):404-5. PMID: 20124191.
      Citations:    
    133. Britten RA, Mitchell S, Johnson AM, Singletary SJ, Keeney SK, Nyalwidhe JO, Karbassi ID, Lonart G, Sanford LD, Drake RR, Britten RA, Mitchell S, Johnson AM, Singletary SJ, Keeney SK, Nyalwidhe JO, Karbassi ID, Lonart G, Sanford LD, Drake RR. The identification of serum biomarkers of high-let radiation exposure and biological sequelae. Health Phys. 2010 Feb; 98(2):196-203. PMID: 20065683.
      Citations:    
    134. Cazares LH, Drake RR, Esquela-Kirscher A, Lance RS, Semmes OJ, Troyer DA, Cazares LH, Drake RR, Esquela-Kirscher A, Lance RS, Semmes OJ, Troyer DA. Molecular pathology of prostate cancer. Cancer Biomark. 2010; 9(1-6):441-59. PMID: 22112489.
      Citations:    
    135. Rauen KA, Schoyer L, McCormick F, Lin AE, Allanson JE, Stevenson DA, Gripp KW, Neri G, Carey JC, Legius E, Tartaglia M, Schubbert S, Roberts AE, Gelb BD, Shannon K, Gutmann DH, McMahon M, Guerra C, Fagin JA, Yu B, Aoki Y, Neel BG, Balmain A, Drake RR, Nolan GP, Zenker M, Bollag G, Sebolt-Leopold J, Gibbs JB, Silva AJ, Patton EE, Viskochil DH, Kieran MW, Korf BR, Hagerman RJ, Packer RJ, Melese T, Rauen KA, Schoyer L, McCormick F, Lin AE, Allanson JE, Stevenson DA, Gripp KW, Neri G, Carey JC, Legius E, Tartaglia M, Schubbert S, Roberts AE, Gelb BD, Shannon K, Gutmann DH, McMahon M, Guerra C, Fagin JA, Yu B, Aoki Y, Neel BG, Balmain A, Drake RR, Nolan GP, Zenker M, Bollag G, Sebolt-Leopold J, Gibbs JB, Silva AJ, Patton EE, Viskochil DH, Kieran MW, Korf BR, Hagerman RJ, Packer RJ, Melese T. Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back. Am J Med Genet A. 2010 Jan; 152A(1):4-24. PMID: 20014119; PMCID: PMC4051786.
      Citations:    
    136. Mellmann A, Bimet F, Bizet C, Borovskaya AD, Drake RR, Eigner U, Fahr AM, He Y, Ilina EN, Kostrzewa M, Maier T, Mancinelli L, Moussaoui W, Prévost G, Putignani L, Seachord CL, Tang YW, Harmsen D, Mellmann A, Bimet F, Bizet C, Borovskaya AD, Drake RR, Eigner U, Fahr AM, He Y, Ilina EN, Kostrzewa M, Maier T, Mancinelli L, Moussaoui W, Pr?vost G, Putignani L, Seachord CL, Tang YW, Harmsen D. High interlaboratory reproducibility of matrix-assisted laser desorption ionization-time of flight mass spectrometry-based species identification of nonfermenting bacteria. J Clin Microbiol. 2009 Nov; 47(11):3732-4. PMID: 19776231; PMCID: PMC2772641.
      Citations:    
    137. Karbassi ID, Nyalwidhe JO, Wilkins CE, Cazares LH, Lance RS, Semmes OJ, Drake RR, Karbassi ID, Nyalwidhe JO, Wilkins CE, Cazares LH, Lance RS, Semmes OJ, Drake RR. Proteomic expression profiling and identification of serum proteins using immobilized trypsin beads with MALDI-TOF/TOF. J Proteome Res. 2009 Sep; 8(9):4182-92. PMID: 19603828.
      Citations:    
    138. Cazares LH, Troyer D, Mendrinos S, Lance RA, Nyalwidhe JO, Beydoun HA, Clements MA, Drake RR, Semmes OJ, Cazares LH, Troyer D, Mendrinos S, Lance RA, Nyalwidhe JO, Beydoun HA, Clements MA, Drake RR, Semmes OJ. Imaging mass spectrometry of a specific fragment of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 2 discriminates cancer from uninvolved prostate tissue. Clin Cancer Res. 2009 Sep 01; 15(17):5541-51. PMID: 19690195.
      Citations:    
    139. Schiessl C, Schestag I, Sittl R, Drake R, Zernikow B, Schiessl C, Schestag I, Sittl R, Drake R, Zernikow B. Rhythmic pattern of PCA opioid demand in adults with cancer pain. Eur J Pain. 2010 Apr; 14(4):372-9. PMID: 19664944.
      Citations:    
    140. Jing Y, Shaheen E, Drake RR, Chen N, Gravenstein S, Deng Y, Jing Y, Shaheen E, Drake RR, Chen N, Gravenstein S, Deng Y. Aging is associated with a numerical and functional decline in plasmacytoid dendritic cells, whereas myeloid dendritic cells are relatively unaltered in human peripheral blood. Hum Immunol. 2009 Oct; 70(10):777-84. PMID: 19596035; PMCID: PMC5718338.
      Citations:    
    141. Schaub NP, Jones KJ, Nyalwidhe JO, Cazares LH, Karbassi ID, Semmes OJ, Feliberti EC, Perry RR, Drake RR, Schaub NP, Jones KJ, Nyalwidhe JO, Cazares LH, Karbassi ID, Semmes OJ, Feliberti EC, Perry RR, Drake RR. Serum proteomic biomarker discovery reflective of stage and obesity in breast cancer patients. J Am Coll Surg. 2009 May; 208(5):970-8; discussion 978-80. PMID: 19476873.
      Citations:    
    142. White KY, Rodemich L, Nyalwidhe JO, Comunale MA, Clements MA, Lance RS, Schellhammer PF, Mehta AS, Semmes OJ, Drake RR, White KY, Rodemich L, Nyalwidhe JO, Comunale MA, Clements MA, Lance RS, Schellhammer PF, Mehta AS, Semmes OJ, Drake RR. Glycomic characterization of prostate-specific antigen and prostatic acid phosphatase in prostate cancer and benign disease seminal plasma fluids. J Proteome Res. 2009 Feb; 8(2):620-30. PMID: 19128049; PMCID: PMC2651839.
      Citations:    
    143. Drake RR, White KY, Fuller TW, Igwe E, Clements MA, Nyalwidhe JO, Given RW, Lance RS, Semmes OJ, Drake RR, White KY, Fuller TW, Igwe E, Clements MA, Nyalwidhe JO, Given RW, Lance RS, Semmes OJ. Clinical collection and protein properties of expressed prostatic secretions as a source for biomarkers of prostatic disease. J Proteomics. 2009 Aug 20; 72(6):907-17. PMID: 19457353; PMCID: PMC2720443.
      Citations:    
    144. Tracy MB, Chen H, Weaver DM, Malyarenko DI, Sasinowski M, Cazares LH, Drake RR, Semmes OJ, Tracy ER, Cooke WE, Tracy MB, Chen H, Weaver DM, Malyarenko DI, Sasinowski M, Cazares LH, Drake RR, Semmes OJ, Tracy ER, Cooke WE. Precision enhancement of MALDI-TOF MS using high resolution peak detection and label-free alignment. Proteomics. 2008 Apr; 8(8):1530-8. PMID: 18340636; PMCID: PMC2413415.
      Citations:    
    145. Freed GL, Cazares LH, Fichandler CE, Fuller TW, Sawyer CA, Stack BC, Schraff S, Semmes OJ, Wadsworth JT, Drake RR, Freed GL, Cazares LH, Fichandler CE, Fuller TW, Sawyer CA, Stack BC, Schraff S, Semmes OJ, Wadsworth JT, Drake RR. Differential capture of serum proteins for expression profiling and biomarker discovery in pre- and posttreatment head and neck cancer samples. Laryngoscope. 2008 Jan; 118(1):61-8. PMID: 18043497.
      Citations:    
    146. Laronga C, Drake RR, Laronga C, Drake RR. Proteomic approach to breast cancer. Cancer Control. 2007 Oct; 14(4):360-8. PMID: 17914336.
      Citations:    
    147. Drake RR, Cazares L, Semmes OJ, Drake RR, Cazares L, Semmes OJ. Mining the low molecular weight proteome of blood. Proteomics Clin Appl. 2007 Aug; 1(8):758-68. PMID: 21136732.
      Citations:    
    148. Shin S, Cazares L, Schneider H, Mitchell S, Laronga C, Semmes OJ, Perry RR, Drake RR, Shin S, Cazares L, Schneider H, Mitchell S, Laronga C, Semmes OJ, Perry RR, Drake RR. Serum biomarkers to differentiate benign and malignant mammographic lesions. J Am Coll Surg. 2007 May; 204(5):1065-71; discussion 1071-3. PMID: 17481542.
      Citations:    
    149. Drake RR, Schwegler EE, Malik G, Diaz J, Block T, Mehta A, Semmes OJ, Drake RR, Schwegler EE, Malik G, Diaz J, Block T, Mehta A, Semmes OJ. Lectin capture strategies combined with mass spectrometry for the discovery of serum glycoprotein biomarkers. Mol Cell Proteomics. 2006 Oct; 5(10):1957-67. PMID: 16760258.
      Citations:    
    150. Xiong Y, Bernardi D, Bratton S, Ward MD, Battaglia E, Finel M, Drake RR, Radominska-Pandya A, Xiong Y, Bernardi D, Bratton S, Ward MD, Battaglia E, Finel M, Drake RR, Radominska-Pandya A. Phenylalanine 90 and 93 are localized within the phenol binding site of human UDP-glucuronosyltransferase 1A10 as determined by photoaffinity labeling, mass spectrometry, and site-directed mutagenesis. Biochemistry. 2006 Feb 21; 45(7):2322-32. PMID: 16475821.
      Citations:    
    151. Malyarenko DI, Cooke WE, Tracy ER, Drake RR, Shin S, Semmes OJ, Sasinowski M, Manos DM, Malyarenko DI, Cooke WE, Tracy ER, Drake RR, Shin S, Semmes OJ, Sasinowski M, Manos DM. Resampling and deconvolution of linear time-of-flight records for enhanced protein profiling. Rapid Commun Mass Spectrom. 2006; 20(11):1670-8. PMID: 16637003; PMCID: PMC7432531.
      Citations:    
    152. Li AJ, Giuntoli RL, Drake R, Byun SY, Rojas F, Barbuto D, Klipfel N, Edmonds P, Miller DS, Karlan BY, Li AJ, Giuntoli RL, Drake R, Byun SY, Rojas F, Barbuto D, Klipfel N, Edmonds P, Miller DS, Karlan BY. Ovarian preservation in stage I low-grade endometrial stromal sarcomas. Obstet Gynecol. 2005 Dec; 106(6):1304-8. PMID: 16319256.
      Citations:    
    153. Britten RA, Hardy C, Vlahou A, Gregory B, Giri PS, Drake R, Britten RA, Hardy C, Vlahou A, Gregory B, Giri PS, Drake R. Identification of reproducible low mass SELDI protein profiles specific to cisplatin resistance in human ovarian cancer cells. Oncol Rep. 2005 Nov; 14(5):1323-30. PMID: 16211304.
      Citations:    
    154. Drake RR, Deng Y, Schwegler EE, Gravenstein S, Drake RR, Deng Y, Schwegler EE, Gravenstein S. Proteomics for biodefense applications: progress and opportunities. Expert Rev Proteomics. 2005 Apr; 2(2):203-13. PMID: 15892565; PMCID: PMC7105753.
      Citations:    
    155. Schwegler EE, Cazares L, Steel LF, Adam BL, Johnson DA, Semmes OJ, Block TM, Marrero JA, Drake RR, Schwegler EE, Cazares L, Steel LF, Adam BL, Johnson DA, Semmes OJ, Block TM, Marrero JA, Drake RR. SELDI-TOF MS profiling of serum for detection of the progression of chronic hepatitis C to hepatocellular carcinoma. Hepatology. 2005 Mar; 41(3):634-42. PMID: 15726646.
      Citations:    
    156. Drake RR, Cazare LH, Semmes OJ, Wadsworth JT, Drake RR, Cazare LH, Semmes OJ, Wadsworth JT. Serum, salivary and tissue proteomics for discovery of biomarkers for head and neck cancers. Expert Rev Mol Diagn. 2005 Jan; 5(1):93-100. PMID: 15723595.
      Citations:    
    157. Becker S, Cazares LH, Watson P, Lynch H, Semmes OJ, Drake RR, Laronga C, Becker S, Cazares LH, Watson P, Lynch H, Semmes OJ, Drake RR, Laronga C. Surfaced-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) differentiation of serum protein profiles of BRCA-1 and sporadic breast cancer. Ann Surg Oncol. 2004 Oct; 11(10):907-14. PMID: 15383419.
      Citations:    
    158. Pusztai L, Gregory BW, Baggerly KA, Peng B, Koomen J, Kuerer HM, Esteva FJ, Symmans WF, Wagner P, Hortobagyi GN, Laronga C, Semmes OJ, Wright GL, Drake RR, Vlahou A, Pusztai L, Gregory BW, Baggerly KA, Peng B, Koomen J, Kuerer HM, Esteva FJ, Symmans WF, Wagner P, Hortobagyi GN, Laronga C, Semmes OJ, Wright GL, Drake RR, Vlahou A. Pharmacoproteomic analysis of prechemotherapy and postchemotherapy plasma samples from patients receiving neoadjuvant or adjuvant chemotherapy for breast carcinoma. Cancer. 2004 May 01; 100(9):1814-22. PMID: 15112261.
      Citations:    
    159. Comunale MA, Mattu TS, Lowman MA, Evans AA, London WT, Semmes OJ, Ward M, Drake R, Romano PR, Steel LF, Block TM, Mehta A, Comunale MA, Mattu TS, Lowman MA, Evans AA, London WT, Semmes OJ, Ward M, Drake R, Romano PR, Steel LF, Block TM, Mehta A. Comparative proteomic analysis of de-N-glycosylated serum from hepatitis B carriers reveals polypeptides that correlate with disease status. Proteomics. 2004 Mar; 4(3):826-38. PMID: 14997503.
      Citations: 16     Fields:    Translation:HumansCells
    160. Laronga C, Becker S, Watson P, Gregory B, Cazares L, Lynch H, Perry RR, Wright GL, Drake RR, Semmes OJ, Laronga C, Becker S, Watson P, Gregory B, Cazares L, Lynch H, Perry RR, Wright GL, Drake RR, Semmes OJ. SELDI-TOF serum profiling for prognostic and diagnostic classification of breast cancers. Dis Markers. 2003-2004; 19(4-5):229-38. PMID: 15258337; PMCID: PMC3851103.
      Citations:    
    161. Mercer KE, Ahn CE, Coke A, Compadre CM, Drake RR, Mercer KE, Ahn CE, Coke A, Compadre CM, Drake RR. Mutation of herpesvirus thymidine kinase to generate ganciclovir-specific kinases for use in cancer gene therapies. Protein Eng. 2002 Nov; 15(11):903-11. PMID: 12538910.
      Citations: 6     Fields:    Translation:HumansCells
    162. Adachi M, Sampath J, Lan LB, Sun D, Hargrove P, Flatley R, Tatum A, Edwards MZ, Wezeman M, Matherly L, Drake R, Schuetz J. Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing. J Biol Chem. 2002 Oct 11; 277(41):38998-9004. PMID: 12105214.
      Citations: 24     Fields:    Translation:HumansCells
    163. Drake RR, Pitlyk K, McMasters RA, Mercer KE, Young H, Moyer MP, Drake RR, Pitlyk K, McMasters RA, Mercer KE, Young H, Moyer MP. Connexin-independent ganciclovir-mediated killing conferred on bystander effect-resistant cell lines by a herpes simplex virus-thymidine kinase-expressing colon cell line. Mol Ther. 2000 Nov; 2(5):515-23. PMID: 11082325.
      Citations: 6     Fields:    Translation:HumansCells
    164. Hinds TA, Compadre C, Hurlburt BK, Drake RR, Hinds TA, Compadre C, Hurlburt BK, Drake RR. Conservative mutations of glutamine-125 in herpes simplex virus type 1 thymidine kinase result in a ganciclovir kinase with minimal deoxypyrimidine kinase activities. Biochemistry. 2000 Apr 11; 39(14):4105-11. PMID: 10747801.
      Citations: 8     Fields:    Translation:Cells
    165. McMasters RA, Wilbert TN, Jones KE, Pitlyk K, Saylors RL, Moyer MP, Chambers TC, Drake RR, McMasters RA, Wilbert TN, Jones KE, Pitlyk K, Saylors RL, Moyer MP, Chambers TC, Drake RR. Two-drug combinations that increase apoptosis and modulate bak and bcl-X(L) expression in human colon tumor cell lines transduced with herpes simplex virus thymidine kinase. Cancer Gene Ther. 2000 Apr; 7(4):563-73. PMID: 10811474.
      Citations: 3     Fields:    Translation:HumansCells
    166. Kim YG, Bi W, Feliciano ES, Drake RR, Stambrook PJ, Kim YG, Bi W, Feliciano ES, Drake RR, Stambrook PJ. Ganciclovir-mediated cell killing and bystander effect is enhanced in cells with two copies of the herpes simplex virus thymidine kinase gene. Cancer Gene Ther. 2000 Feb; 7(2):240-6. PMID: 10770632.
      Citations: 7     Fields:    Translation:HumansCells
    167. Wang-Gillam A, Pastuszak I, Stewart M, Drake RR, Elbein AD, Wang-Gillam A, Pastuszak I, Stewart M, Drake RR, Elbein AD. Identification and modification of the uridine-binding site of the UDP-GalNAc (GlcNAc) pyrophosphorylase. J Biol Chem. 2000 Jan 14; 275(2):1433-8. PMID: 10625695.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    168. Drake RR, Wilbert TN, Hinds TA, Gilbert KM, Drake RR, Wilbert TN, Hinds TA, Gilbert KM. Differential ganciclovir-mediated cell killing by glutamine 125 mutants of herpes simplex virus type 1 thymidine kinase. J Biol Chem. 1999 Dec 24; 274(52):37186-92. PMID: 10601281.
      Citations: 3     Fields:    Translation:AnimalsCells
    169. Haddock G, Tarrier N, Morrison AP, Hopkins R, Drake R, Lewis S, Haddock G, Tarrier N, Morrison AP, Hopkins R, Drake R, Lewis S. A pilot study evaluating the effectiveness of individual inpatient cognitive-behavioural therapy in early psychosis. Soc Psychiatry Psychiatr Epidemiol. 1999 May; 34(5):254-8. PMID: 10396167.
      Citations: 24     Fields:    Translation:HumansCTClinical Trials
    170. Little JM, Lester R, Kuipers F, Vonk R, Mackenzie PI, Drake RR, Frame L, Radominska-Pandya A, Little JM, Lester R, Kuipers F, Vonk R, Mackenzie PI, Drake RR, Frame L, Radominska-Pandya A. Variability of human hepatic UDP-glucuronosyltransferase activity. Acta Biochim Pol. 1999; 46(2):351-63. PMID: 10547036.
      Citations: 1     Fields:    Translation:HumansCells
    171. Pastuszak I, Ketchum C, Hermanson G, Sjoberg EJ, Drake R, Elbein AD, Pastuszak I, Ketchum C, Hermanson G, Sjoberg EJ, Drake R, Elbein AD. GDP-L-fucose pyrophosphorylase. Purification, cDNA cloning, and properties of the enzyme. J Biol Chem. 1998 Nov 13; 273(46):30165-74. PMID: 9804772.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    172. McMasters RA, Saylors RL, Jones KE, Hendrix ME, Moyer MP, Drake RR, McMasters RA, Saylors RL, Jones KE, Hendrix ME, Moyer MP, Drake RR. Lack of bystander killing in herpes simplex virus thymidine kinase-transduced colon cell lines due to deficient connexin43 gap junction formation. Hum Gene Ther. 1998 Oct 10; 9(15):2253-61. PMID: 9794209.
      Citations: 9     Fields:    Translation:HumansCells
    173. Sunthankar P, Pastuszak I, Rooke A, Elbein AD, van de Rijn I, Canfield WM, Drake RR, Sunthankar P, Pastuszak I, Rooke A, Elbein AD, van de Rijn I, Canfield WM, Drake RR. Synthesis of 5-azido-UDP-N-acetylhexosamine photoaffinity analogs and radiolabeled UDP-N-acetylhexosamines. Anal Biochem. 1998 May 01; 258(2):195-201. PMID: 9570829.
      Citations: 3     Fields:    Translation:AnimalsCells
    174. Drake RR, Neamati N, Hong H, Pilon AA, Sunthankar P, Hume SD, Milne GW, Pommier Y, Drake RR, Neamati N, Hong H, Pilon AA, Sunthankar P, Hume SD, Milne GW, Pommier Y. Identification of a nucleotide binding site in HIV-1 integrase. Proc Natl Acad Sci U S A. 1998 Apr 14; 95(8):4170-5. PMID: 9539708; PMCID: PMC22460.
      Citations: 12     Fields:    Translation:Cells
    175. DeAngelis PL, Jing W, Drake RR, Achyuthan AM, DeAngelis PL, Jing W, Drake RR, Achyuthan AM. Identification and molecular cloning of a unique hyaluronan synthase from Pasteurella multocida. J Biol Chem. 1998 Apr 03; 273(14):8454-8. PMID: 9525958.
      Citations: 31     Fields:    Translation:Cells
    176. Park SH, Pastuszak I, Drake R, Elbein AD, Park SH, Pastuszak I, Drake R, Elbein AD. Purification to apparent homogeneity and properties of pig kidney L-fucose kinase. J Biol Chem. 1998 Mar 06; 273(10):5685-91. PMID: 9488699.
      Citations: 18     Fields:    Translation:AnimalsCells
    177. Zeng Y, Bannon G, Thomas VH, Rice K, Drake R, Elbein A, Zeng Y, Bannon G, Thomas VH, Rice K, Drake R, Elbein A. Purification and specificity of beta1,2-xylosyltransferase, an enzyme that contributes to the allergenicity of some plant proteins. J Biol Chem. 1997 Dec 12; 272(50):31340-7. PMID: 9395463.
      Citations: 15     Fields:    Translation:AnimalsCells
    178. Drake RR, McMasters R, Krisa S, Hume SD, Rechtin TM, Saylors RL, Chiang Y, Govindarajan R, Munshi NC, Drake RR, McMasters R, Krisa S, Hume SD, Rechtin TM, Saylors RL, Chiang Y, Govindarajan R, Munshi NC. Metabolism and activities of 3'-azido-2',3'-dideoxythymidine and 2',3'-didehydro-2',3'-dideoxythymidine in herpesvirus thymidine kinase transduced T-lymphocytes. Antiviral Res. 1997 Aug; 35(3):177-85. PMID: 9298757.
      Citations:    Fields:    Translation:HumansCells
    179. Sugumaran G, Katsman M, Sunthankar P, Drake RR, Sugumaran G, Katsman M, Sunthankar P, Drake RR. Biosynthesis of chondroitin sulfate. Purification of glucuronosyl transferase II and use of photoaffinity labeling for characterization of the enzyme as an 80-kDa protein. J Biol Chem. 1997 May 30; 272(22):14399-403. PMID: 9162078.
      Citations: 3     Fields:    Translation:AnimalsCells
    180. Orr RK, Hoehn JL, Col NF, Battaglia E, Nowell S, Drake RR, Magdalou J, Fournel-Gigleux S, Senay C, Radominska A. Photoaffinity labeling studies of the human recombinant UDP-glucuronosyltransferase, UGT1*6, with 5-azido-UDP-glucuronic acid. Drug Metab Dispos. 1997 Apr; 25(4):406-11. PMID: 9107538.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    181. Munshi NC, Govindarajan R, Drake R, Ding LM, Iyer R, Saylors R, Kornbluth J, Marcus S, Chiang Y, Ennist D, Kwak L, Reynolds C, Tricot G, Barlogie B, Munshi NC, Govindarajan R, Drake R, Ding LM, Iyer R, Saylors R, Kornbluth J, Marcus S, Chiang Y, Ennist D, Kwak L, Reynolds C, Tricot G, Barlogie B. Thymidine kinase (TK) gene-transduced human lymphocytes can be highly purified, remain fully functional, and are killed efficiently with ganciclovir. Blood. 1997 Feb 15; 89(4):1334-40. PMID: 9028956.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    182. Orr RK, Hoehn JL, Col NF, Bao M, Elmendorf BJ, Booth JL, Drake RR, Canfield WM. Bovine UDP-N-acetylglucosamine:lysosomal-enzyme N-acetylglucosamine-1-phosphotransferase. II. Enzymatic characterization and identification of the catalytic subunit. J Biol Chem. 1996 Dec 06; 271(49):31446-51. PMID: 8940156.
      Citations: 16     Fields:    Translation:AnimalsCells
    183. Battaglia E, Nowell S, Drake RR, Mizeracka M, Berg CL, Magdalou J, Fournel-Gigleux S, Gollan JL, Lester R, Radominska A, Battaglia E, Nowell S, Drake RR, Mizeracka M, Berg CL, Magdalou J, Fournel-Gigleux S, Gollan JL, Lester R, Radominska A. Two kinetically-distinct components of UDP-glucuronic acid transport in rat liver endoplasmic reticulum. Biochim Biophys Acta. 1996 Sep 04; 1283(2):223-31. PMID: 8809103.
      Citations: 2     Fields:    Translation:AnimalsCells
    184. Pastuszak I, Drake R, Elbein AD, Pastuszak I, Drake R, Elbein AD. Kidney N-acetylgalactosamine (GalNAc)-1-phosphate kinase, a new pathway of GalNAc activation. J Biol Chem. 1996 Aug 23; 271(34):20776-82. PMID: 8702831.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    185. Zeng Y, Shabalin Y, Szumilo T, Pastuszak I, Drake RR, Elbein AD, Zeng Y, Shabalin Y, Szumilo T, Pastuszak I, Drake RR, Elbein AD. Synthesis of aryl azide derivatives of UDP-GlcNAc and UDP-GalNAc and their use for the affinity labeling of glycosyltransferases and the UDP-HexNAc pyrophosphorylase. Anal Biochem. 1996 Jul 15; 239(1):99-106. PMID: 8660631.
      Citations: 1     Fields:    Translation:Animals
    186. Black ME, Rechtin TM, Drake RR, Black ME, Rechtin TM, Drake RR. Effect on substrate binding of an alteration at the conserved aspartic acid-162 in herpes simplex virus type 1 thymidine kinase. J Gen Virol. 1996 Jul; 77 ( Pt 7):1521-7. PMID: 8757995.
      Citations: 3     Fields:    Translation:HumansCells
    187. Pan YT, Drake RR, Elbein AD, Pan YT, Drake RR, Elbein AD. Trehalose-P synthase of mycobacteria: its substrate specificity is affected by polyanions. Glycobiology. 1996 Jun; 6(4):453-61. PMID: 8842710.
      Citations: 3     Fields:    Translation:Cells
    188. Szumilo T, Zeng Y, Pastuszak I, Drake R, Szumilo H, Elbein AD, Szumilo T, Zeng Y, Pastuszak I, Drake R, Szumilo H, Elbein AD. Purification to homogeneity and properties of UDP-GlcNAc (GalNAc) pyrophosphorylase. J Biol Chem. 1996 May 31; 271(22):13147-54. PMID: 8662687.
      Citations: 6     Fields:    Translation:Animals
    189. Rechtin TM, Black ME, Drake RR, Rechtin TM, Black ME, Drake RR. Proteolytic mapping of the thymidine/thymidylate binding site of herpes simplex virus type 1 thymidine kinase: a general photoaffinity labeling method for identifying active-site peptides. Anal Biochem. 1996 May 15; 237(1):135-40. PMID: 8660548.
      Citations: 2     Fields:    Translation:Cells
    190. Radominska A, Drake RR, Zhu X, Veronese ME, Little JM, Nowell S, McManus ME, Lester R, Falany CN, Radominska A, Drake RR, Zhu X, Veronese ME, Little JM, Nowell S, McManus ME, Lester R, Falany CN. Photoaffinity labeling of human recombinant sulfotransferases with 2-azidoadenosine 3',5'-[5'-32P]bisphosphate. J Biol Chem. 1996 Feb 09; 271(6):3195-9. PMID: 8621720.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    191. Sugumaran G, Katsman M, Drake RR, Sugumaran G, Katsman M, Drake RR. Purification, photoaffinity labeling, and characterization of a single enzyme for 6-sulfation of both chondroitin sulfate and keratan sulfate. J Biol Chem. 1995 Sep 22; 270(38):22483-7. PMID: 7673238.
      Citations: 3     Fields:    Translation:Animals
    192. Mao F, Rechtin TM, Jones R, Cantu AA, Anderson LS, Radominska A, Moyer MP, Drake RR, Mao F, Rechtin TM, Jones R, Cantu AA, Anderson LS, Radominska A, Moyer MP, Drake RR. Synthesis of a photoaffinity analog of 3'-azidothymidine, 5-azido-3'-azido-2',3'-dideoxyuridine. Interactions with herpesvirus thymidine kinase and cellular enzymes. J Biol Chem. 1995 Jun 09; 270(23):13660-4. PMID: 7775417.
      Citations: 1     Fields:    Translation:AnimalsCells
    193. Little JM, Drake RR, Vonk R, Kuipers F, Lester R, Radominska A, Little JM, Drake RR, Vonk R, Kuipers F, Lester R, Radominska A. Characterization of human liver microsomal UDP-glycosyltransferases using photoaffinity analogs. J Pharmacol Exp Ther. 1995 Jun; 273(3):1551-9. PMID: 7791131.
      Citations: 2     Fields:    Translation:HumansCells
    194. Zhu BC, Drake RR, Schweingruber H, Laine RA, Zhu BC, Drake RR, Schweingruber H, Laine RA. Inhibition of glycosylation by amphomycin and sugar nucleotide analogs PP36 and PP55 indicates that Haloferax volcanii beta-glucosylates both glycoproteins and glycolipids through lipid-linked sugar intermediates: evidence for three novel glycoproteins and a novel sulfated dihexosyl-archaeol glycolipid. Arch Biochem Biophys. 1995 Jun 01; 319(2):355-64. PMID: 7786016.
      Citations: 10     Fields:    Translation:Cells
    195. Rechtin TM, Black ME, Mao F, Lewis ML, Drake RR, Rechtin TM, Black ME, Mao F, Lewis ML, Drake RR. Purification and photoaffinity labeling of herpes simplex virus type-1 thymidine kinase. J Biol Chem. 1995 Mar 31; 270(13):7055-60. PMID: 7706243.
      Citations: 6     Fields:    Translation:HumansCells
    196. Batchu RB, Miles DA, Rechtin TM, Drake RR, Hermonat PL, Batchu RB, Miles DA, Rechtin TM, Drake RR, Hermonat PL. Cloning, expression and purification of full length Rep78 of adeno-associated virus as a fusion protein with maltose binding protein in Escherichia coli. Biochem Biophys Res Commun. 1995 Mar 17; 208(2):714-20. PMID: 7695627.
      Citations: 1     Fields:    Translation:Cells
    197. Kyossev ZN, Drake RR, Kyosseva SV, Elbein AD, Kyossev ZN, Drake RR, Kyosseva SV, Elbein AD. Synthesis of a new photoaffinity probe, 5-azido-[32P]UDPxylose, by UDPglucuronate carboxylyase from wheat germ. Eur J Biochem. 1995 Feb 15; 228(1):109-12. PMID: 7882990.
      Citations: 3     Fields:    Translation:Animals
    198. Battaglia E, Elass A, Drake RR, Paul P, Treat S, Magdalou J, Fournel-Gigleux S, Siest G, Vergoten G, Lester R, Battaglia E, Elass A, Drake RR, Paul P, Treat S, Magdalou J, Fournel-Gigleux S, Siest G, Vergoten G, Lester R, et al. Characterization of a new class of inhibitors of the recombinant human liver UDP-glucuronosyltransferase, UGT1*6. Biochim Biophys Acta. 1995 Jan 18; 1243(1):9-14. PMID: 7827113.
      Citations: 1     Fields:    Translation:HumansCells
    199. Orr RK, Hoehn JL, Col NF, Radominska A, Berg C, Treat S, Little JM, Lester R, Gollan JL, Drake RR. Characterization of UDP-glucuronic acid transport in rat liver microsomal vesicles with photoaffinity analogs. Biochim Biophys Acta. 1994 Oct 12; 1195(1):63-70. PMID: 7918567.
      Citations: 3     Fields:    Translation:AnimalsCells
    200. Radominska A, Paul P, Treat S, Towbin H, Pratt C, Little J, Magdalou J, Lester R, Drake R, Radominska A, Paul P, Treat S, Towbin H, Pratt C, Little J, Magdalou J, Lester R, Drake R. Photoaffinity labeling for evaluation of uridinyl analogs as specific inhibitors of rat liver microsomal UDP-glucuronosyltransferases. Biochim Biophys Acta. 1994 Apr 13; 1205(2):336-45. PMID: 8155717.
      Citations: 1     Fields:    Translation:AnimalsCells
    201. Radominska A, Drake RR, Radominska A, Drake RR. Synthesis and uses of azido-substituted nucleoside diphosphate sugar photoaffinity analogs. Methods Enzymol. 1994; 230:330-9. PMID: 8139506.
      Citations: 3     Fields:    Translation:AnimalsCells
    202. Pillot T, Ouzzine M, Fournel-Gigleux S, Lafaurie C, Radominska A, Lester R, Drake R, Treat S, Siest G, Magdalou J, Pillot T, Ouzzine M, Fournel-Gigleux S, Lafaurie C, Radominska A, Lester R, Drake R, Treat S, Siest G, Magdalou J. Purification and characterization of a catalytically active human liver UDP-glucuronosyltransferase expressed as a fusion protein in E. coli. Biochem Biophys Res Commun. 1993 Oct 15; 196(1):473-9. PMID: 8216331.
      Citations: 1     Fields:    Translation:HumansCells
    203. Szumilo T, Drake RR, York JL, Elbein AD, Szumilo T, Drake RR, York JL, Elbein AD. GDP-mannose pyrophosphorylase. Purification to homogeneity, properties, and utilization to prepare photoaffinity analogs. J Biol Chem. 1993 Aug 25; 268(24):17943-50. PMID: 7688733.
      Citations: 16     Fields:    Translation:AnimalsCells
    204. Radominska A, Little J, Pyrek JS, Drake RR, Igari Y, Fournel-Gigleux S, Magdalou J, Burchell B, Elbein AD, Siest G, Radominska A, Little J, Pyrek JS, Drake RR, Igari Y, Fournel-Gigleux S, Magdalou J, Burchell B, Elbein AD, Siest G, et al. A novel UDP-Glc-specific glucosyltransferase catalyzing the biosynthesis of 6-O-glucosides of bile acids in human liver microsomes. J Biol Chem. 1993 Jul 15; 268(20):15127-35. PMID: 8325887.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    205. Paul P, Lutz TM, Osborn C, Kyosseva S, Elbein AD, Towbin H, Radominska A, Drake RR. Synthesis and characterization of a new class of inhibitors of membrane-associated UDP-glycosyltransferases. J Biol Chem. 1993 Jun 15; 268(17):12933-8. PMID: 8509426.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    206. Li L, Drake RR, Clement S, Brown RM, Li L, Drake RR, Clement S, Brown RM. [beta]-Glucan Synthesis in the Cotton Fiber (III. Identification of UDP-Glucose-Binding Subunits of [beta]-Glucan Synthases by Photoaffinity Labeling with [[beta]-32P]5[prime]-N3-UDP-Glucose. Plant Physiol. 1993 Apr; 101(4):1149-1156. PMID: 12231766; PMCID: PMC160632.
      Citations: 5     Fields:    
    207. van de Rijn I, Drake RR, van de Rijn I, Drake RR. Analysis of the streptococcal hyaluronic acid synthase complex using the photoaffinity probe 5-azido-UDP-glucuronic acid. J Biol Chem. 1992 Dec 05; 267(34):24302-6. PMID: 1447180.
      Citations: 1     Fields:    Translation:Cells
    208. Drake RR, Elbein AD, Drake RR, Elbein AD. Photoaffinity labelling of glycosyltransferases. Glycobiology. 1992 Aug; 2(4):279-84. PMID: 1421749.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    209. Drake RR, Igari Y, Lester R, Elbein AD, Radominska A, Drake RR, Igari Y, Lester R, Elbein AD, Radominska A. Application of 5-azido-UDP-glucose and 5-azido-UDP-glucuronic acid photoaffinity probes for the determination of the active site orientation of microsomal UDP-glucosyltransferases and UDP-glucuronosyltransferases. J Biol Chem. 1992 Jun 05; 267(16):11360-5. PMID: 1534561.
      Citations: 6     Fields:    Translation:AnimalsCells
    210. Drake RR, Slama JT, Wall KA, Abramova M, D'Souza C, Elbein AD, Crocker PJ, Watt DS, Drake RR, Slama JT, Wall KA, Abramova M, D'Souza C, Elbein AD, Crocker PJ, Watt DS. Application of an N-(4-azido-2,3,5,6-tetrafluorobenzoyl)tyrosine-substituted peptide as a heterobifunctional cross-linking agent in a study of protein O-glycosylation in yeast. Bioconjug Chem. 1992 Jan-Feb; 3(1):69-73. PMID: 1616952.
      Citations:    Fields:    Translation:AnimalsCells
    211. Drake RR, Zimniak P, Haley BE, Lester R, Elbein AD, Radominska A, Drake RR, Zimniak P, Haley BE, Lester R, Elbein AD, Radominska A. Synthesis and characterization of 5-azido-UDP-glucuronic acid. A new photoaffinity probe for UDP-glucuronic acid-utilizing proteins. J Biol Chem. 1991 Dec 05; 266(34):23257-60. PMID: 1744121.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    212. Drake RR, Kaushal GP, Pastuszak I, Elbein AD, Drake RR, Kaushal GP, Pastuszak I, Elbein AD. Partial Purification, Photoaffinity Labeling, and Properties of Mung Bean UDP-Glucose:Dolicholphosphate Glucosyltransferase. Plant Physiol. 1991 Sep; 97(1):396-401. PMID: 16668398; PMCID: PMC1081011.
      Citations:    
    213. Salvucci ME, Drake RR, Haley BE, Salvucci ME, Drake RR, Haley BE. Purification and photoaffinity labeling of sucrose phosphate synthase from spinach leaves. Arch Biochem Biophys. 1990 Sep; 281(2):212-8. PMID: 2144103.
      Citations: 14     Fields:    Translation:Animals
    214. Marchase RB, Richardson KL, Srisomsap C, Drake RR, Haley BE, Marchase RB, Richardson KL, Srisomsap C, Drake RR, Haley BE. Resolution of phosphoglucomatase and the 62-kDA acceptor for the glucosylphosphotransferase. Arch Biochem Biophys. 1990 Jul; 280(1):122-9. PMID: 2162150.
      Citations: 2     Fields:    Translation:AnimalsCells
    215. Palamarczyk G, Drake R, Haley B, Lennarz WJ, Palamarczyk G, Drake R, Haley B, Lennarz WJ. Evidence that the synthesis of glucosylphosphodolichol in yeast involves a 35-kDa membrane protein. Proc Natl Acad Sci U S A. 1990 Apr; 87(7):2666-70. PMID: 2138781; PMCID: PMC53751.
      Citations: 2     Fields:    Translation:AnimalsCells
    216. Lin FC, Brown RM, Drake RR, Haley BE, Lin FC, Brown RM, Drake RR, Haley BE. Identification of the uridine 5'-diphosphoglucose (UDP-Glc) binding subunit of cellulose synthase in Acetobacter xylinum using the photoaffinity probe 5-azido-UDP-Glc. J Biol Chem. 1990 Mar 25; 265(9):4782-4. PMID: 2138620.
      Citations: 32     Fields:    Translation:Cells
    217. Frost DJ, Read SM, Drake RR, Haley BE, Wasserman BP, Frost DJ, Read SM, Drake RR, Haley BE, Wasserman BP. Identification of the UDP-glucose-binding polypeptide of callose synthase from Beta vulgaris L. by photoaffinity labeling with 5-azido-UDP-glucose. J Biol Chem. 1990 Feb 05; 265(4):2162-7. PMID: 2137125.
      Citations: 13     Fields:    Translation:AnimalsCells
    218. Drake R, Palamarczyk G, Haley B, Lennarz WJ, Drake R, Palamarczyk G, Haley B, Lennarz WJ. Evidence for the involvement of a 35-kDa membrane protein in the synthesis of glucosylphosphoryldolichol. Biosci Rep. 1990 Feb; 10(1):61-8. PMID: 2140279.
      Citations: 3     Fields:    Translation:AnimalsCells
    219. Drake RR, Evans RK, Wolf MJ, Haley BE, Drake RR, Evans RK, Wolf MJ, Haley BE. Synthesis and properties of 5-azido-UDP-glucose. Development of photoaffinity probes for nucleotide diphosphate sugar binding sites. J Biol Chem. 1989 Jul 15; 264(20):11928-33. PMID: 2745423.
      Citations: 8     Fields:    Translation:AnimalsCells
    220. Lawson SG, Mason TL, Sabin RD, Sloan ME, Drake RR, Haley BE, Wasserman BP, Lawson SG, Mason TL, Sabin RD, Sloan ME, Drake RR, Haley BE, Wasserman BP. UDP-Glucose: (1,3)-beta-Glucan Synthase from Daucus carota L. : Characterization, Photoaffinity Labeling, and Solubilization. Plant Physiol. 1989 May; 90(1):101-8. PMID: 16666718; PMCID: PMC1061683.
      Citations:    
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