"MutL Protein Homolog 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Eukaryotic homolog of the bacterial MutL DNA MISMATCH REPAIR protein. It heterodimerizes with MISMATCH REPAIR ENDONUCLEASE PMS2 to form MutL alpha, which is recruited to DNA mismatch sites by the MUTS DNA MISMATCH-BINDING PROTEIN. Mutations in the human MLH1 gene are associated with COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS.
| Descriptor ID |
D000070957
|
| MeSH Number(s) |
D08.811.074.766.500 D08.811.277.040.025.215.500 D12.776.260.540.500
|
| Concept/Terms |
MutL Protein Homolog 1- MutL Protein Homolog 1
- MLH1 Protein
- Colon Cancer, Nonpolyposis Type 2 Protein
- MutL Homolog 1
- COCA2 Protein
|
Below are MeSH descriptors whose meaning is more general than "MutL Protein Homolog 1".
Below are MeSH descriptors whose meaning is more specific than "MutL Protein Homolog 1".
This graph shows the total number of publications written about "MutL Protein Homolog 1" by people in this website by year, and whether "MutL Protein Homolog 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2005 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 4 | 4 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 3 | 3 |
| 2013 | 0 | 4 | 4 |
| 2015 | 0 | 4 | 4 |
| 2016 | 1 | 2 | 3 |
| 2019 | 1 | 3 | 4 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "MutL Protein Homolog 1" by people in Profiles.
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Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report. Genet Med. 2021 04; 23(4):705-712.
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Type 2 diabetes mellitus, blood cholesterol, triglyceride and colorectal cancer risk in Lynch syndrome. Br J Cancer. 2019 11; 121(10):869-876.
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Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database. Genet Med. 2020 01; 22(1):15-25.
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DNA repair and cancer in colon and rectum: Novel players in genetic susceptibility. Int J Cancer. 2020 01 15; 146(2):363-372.
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Functional Repair Assay for the Diagnosis of Constitutional Mismatch Repair Deficiency From Non-Neoplastic Tissue. J Clin Oncol. 2019 02 20; 37(6):461-470.
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Prevalence and Penetrance of Major Genes and Polygenes for Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2017 03; 26(3):404-412.
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Determining the familial risk distribution of colorectal cancer: a data mining approach. Fam Cancer. 2016 Apr; 15(2):241-51.
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Germline mutations in PMS2 and MLH1 in individuals with solitary loss of PMS2 expression in colorectal carcinomas from the Colon Cancer Family Registry Cohort. BMJ Open. 2016 Feb 19; 6(2):e010293.
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Risk of colorectal cancer for people with a mutation in both a MUTYH and a DNA mismatch repair gene. Fam Cancer. 2015 Dec; 14(4):575-83.
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Clinicopathologic Risk Factor Distributions for MLH1 Promoter Region Methylation in CIMP-Positive Tumors. Cancer Epidemiol Biomarkers Prev. 2016 Jan; 25(1):68-75.