Suppressor of Cytokine Signaling 3 Protein
"Suppressor of Cytokine Signaling 3 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS3 inhibits cytokine signaling by binding to RECEPTOR PROTEIN-TYROSINE KINASES as well as CYTOKINE RECEPTOR GP130; ERYTHROPOIETIN RECEPTORS; INSULIN RECEPTOR; and the LEPTIN RECEPTOR. Its functions include suppression of ERYTHROPOIESIS in the fetal liver.
| Descriptor ID |
D000071223
|
| MeSH Number(s) |
D12.644.360.024.374.750 D12.776.157.057.249.750 D12.776.476.024.437.750
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Suppressor of Cytokine Signaling 3 Protein".
Below are MeSH descriptors whose meaning is more specific than "Suppressor of Cytokine Signaling 3 Protein".
This graph shows the total number of publications written about "Suppressor of Cytokine Signaling 3 Protein" by people in this website by year, and whether "Suppressor of Cytokine Signaling 3 Protein" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Suppressor of Cytokine Signaling 3 Protein" by people in Profiles.
-
CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling. EMBO J. 2018 09 14; 37(18).
-
Kallistatin treatment attenuates lethality and organ injury in mouse models of established sepsis. Crit Care. 2015 May 01; 19:200.
-
SOCS-1/3 participation in FGF-2 signaling to modulate RANK ligand expression in paget's disease of bone. J Cell Biochem. 2013 Sep; 114(9):2032-8.
-
Loss of expression and function of SOCS3 is an early event in HNSCC: altered subcellular localization as a possible mechanism involved in proliferation, migration and invasion. PLoS One. 2012; 7(9):e45197.
-
Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis. J Immunol. 2010 Aug 15; 185(4):2570-9.
-
Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome. Am J Physiol Endocrinol Metab. 2009 Jul; 297(1):E211-24.
-
The suppressor of cytokine signaling 3 inhibits leptin activation of AMP-kinase in cultured skeletal muscle of obese humans. J Clin Endocrinol Metab. 2006 Sep; 91(9):3592-7.