"AC133 Antigen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A member of the prominin family, AC133 Antigen is a 5-transmembrane antigen occurring as several isoforms produced by alternative splicing which are processed into mature forms. In humans, it is expressed as a subset of CD34 (bright) human hematopoietic stem cells and CD34 positive leukemias. Functionally, it is associated with roles in cell differentiation, proliferation, and apoptosis. Specifically, it regulates the organization of apical plasma membrane in epithelial cells, disk morphogenesis during early retinal development, MAPK and Akt signaling pathways, and in cholesterol metabolism.
| Descriptor ID |
D000071916
|
| MeSH Number(s) |
D12.776.395.550.007 D12.776.543.550.023
|
| Concept/Terms |
AC133 Antigen- AC133 Antigen
- Antigen, AC133
- CD133 Antigen
- Antigen, CD133
- PROML1
- Prominin
- Prominin-1
- Prominin 1
- Prominin-Like PROML1
- Prominin Like PROML1
- AC133-1 Antigen
- AC133 1 Antigen
- Antigen, AC133-1
- Fudenine
|
Below are MeSH descriptors whose meaning is more general than "AC133 Antigen".
Below are MeSH descriptors whose meaning is more specific than "AC133 Antigen".
This graph shows the total number of publications written about "AC133 Antigen" by people in this website by year, and whether "AC133 Antigen" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "AC133 Antigen" by people in Profiles.
-
MicroRNA-92 Expression in CD133+ Melanoma Stem Cells Regulates Immunosuppression in the Tumor Microenvironment via Integrin-Dependent Activation of TGF?. Cancer Res. 2019 07 15; 79(14):3622-3635.
-
Post-translational regulation of CD133 by ATase1/ATase2-mediated lysine acetylation. J Mol Biol. 2014 May 29; 426(11):2175-82.
-
Recruitment of bone marrow-derived valve interstitial cells is a normal homeostatic process. J Mol Cell Cardiol. 2011 Dec; 51(6):955-65.