"Uncoupling Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes.
| Descriptor ID |
D014475
|
| MeSH Number(s) |
D27.505.519.389.936
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Uncoupling Agents".
Below are MeSH descriptors whose meaning is more specific than "Uncoupling Agents".
This graph shows the total number of publications written about "Uncoupling Agents" by people in this website by year, and whether "Uncoupling Agents" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Uncoupling Agents" by people in Profiles.
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Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile. Arch Toxicol. 2017 Jan; 91(1):439-452.
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Role of calcium and ROS in cell death induced by polyunsaturated fatty acids in murine thymocytes. J Cell Physiol. 2010 Nov; 225(3):829-36.
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VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease. Neurobiol Dis. 2010 Feb; 37(2):330-8.
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Extranigral neurodegeneration in Parkinson's disease. Ann N Y Acad Sci. 2008 Oct; 1139:331-6.
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Potassium channel openers are uncoupling protonophores: implication in cardioprotection. FEBS Lett. 2004 Jun 18; 568(1-3):167-70.
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The role of uncoupling protein 3 in human physiology. J Clin Invest. 2003 Feb; 111(4):438-41.
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Expression of mRNAs encoding uncoupling proteins in human skeletal muscle: effects of obesity and diabetes. Diabetes. 1998 Dec; 47(12):1935-40.
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Protection by acidotic pH and fructose against lethal injury to rat hepatocytes from mitochondrial inhibitors, ionophores and oxidant chemicals. Biochem Biophys Res Commun. 1990 Mar 16; 167(2):600-6.
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The energized state of rat liver mitochondria. ATP equivalence, uncoupler sensitivity, and decay kinetics. J Biol Chem. 1980 Jun 25; 255(12):5674-80.