"Tretinoin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).
| Descriptor ID |
D014212
|
| MeSH Number(s) |
D02.455.326.271.665.202.495.818.500 D02.455.426.392.368.367.379.249.700.860.500 D02.455.849.131.495.818.800 D23.767.261.700.780
|
| Concept/Terms |
Tretinoin- Tretinoin
- Retinoic Acid
- Acid, Retinoic
- Vitamin A Acid
- Acid, Vitamin A
- all-trans-Retinoic Acid
- Acid, all-trans-Retinoic
- all trans Retinoic Acid
- trans-Retinoic Acid
- Acid, trans-Retinoic
- trans Retinoic Acid
|
Below are MeSH descriptors whose meaning is more general than "Tretinoin".
Below are MeSH descriptors whose meaning is more specific than "Tretinoin".
This graph shows the total number of publications written about "Tretinoin" by people in this website by year, and whether "Tretinoin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 1 | 1 |
| 1994 | 0 | 2 | 2 |
| 1995 | 2 | 2 | 4 |
| 1996 | 2 | 0 | 2 |
| 1997 | 1 | 2 | 3 |
| 1999 | 1 | 1 | 2 |
| 2000 | 2 | 3 | 5 |
| 2002 | 1 | 3 | 4 |
| 2003 | 2 | 0 | 2 |
| 2004 | 1 | 1 | 2 |
| 2005 | 2 | 3 | 5 |
| 2006 | 1 | 1 | 2 |
| 2007 | 4 | 7 | 11 |
| 2008 | 1 | 2 | 3 |
| 2009 | 2 | 0 | 2 |
| 2010 | 1 | 1 | 2 |
| 2011 | 3 | 1 | 4 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 3 | 4 |
| 2015 | 0 | 1 | 1 |
| 2016 | 2 | 0 | 2 |
| 2017 | 1 | 0 | 1 |
| 2021 | 0 | 2 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Tretinoin" by people in Profiles.
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Treffy RW, Rajan SG, Jiang X, Nacke LM, Malkana UA, Naiche LA, Bergey DE, Santana D, Rajagopalan V, Kitajewski JK, O'Bryan JP, Saxena A. Neuroblastoma differentiation in vivo excludes cranial tumors. Dev Cell. 2021 10 11; 56(19):2752-2764.e6.
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Sanaei K, Plotner S, Oommen Jacob A, Ramirez-Vick J, Vyavahare N, Nosoudi N. Effect of all-trans retinoic acid and pentagalloyl glucose on smooth muscle cell elastogenesis. Biomed Mater Eng. 2021; 32(3):145-157.
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Hinen HB, Gathings RM, Shuler M, Wine Lee L. Successful treatment of facial milia in an infant with orofaciodigital syndrome type 1. Pediatr Dermatol. 2018 Jan; 35(1):e88-e89.
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Clarke CJ, Shamseddine AA, Jacob JJ, Khalife G, Burns TA, Hannun YA. ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation. J Lipid Res. 2016 05; 57(5):868-81.
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Chakrabarti M, McDonald AJ, Will Reed J, Moss MA, Das BC, Ray SK. Molecular Signaling Mechanisms of Natural and Synthetic Retinoids for Inhibition of Pathogenesis in Alzheimer's Disease. J Alzheimers Dis. 2016; 50(2):335-52.
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Adler L, Boyer NP, Chen C, Koutalos Y. Kinetics of rhodopsin's chromophore monitored in a single photoreceptor. Methods Mol Biol. 2015; 1271:327-43.
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Das BC, Thapa P, Karki R, Das S, Mahapatra S, Liu TC, Torregroza I, Wallace DP, Kambhampati S, Van Veldhuizen P, Verma A, Ray SK, Evans T. Retinoic acid signaling pathways in development and diseases. Bioorg Med Chem. 2014 Jan 15; 22(2):673-83.
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Zaenglein AL, Shamban A, Webster G, Del Rosso J, Dover JS, Swinyer L, Stein L, Lin X, Draelos Z, Gold M, Thiboutot D. A phase IV, open-label study evaluating the use of triple-combination therapy with minocycline HCl extended-release tablets, a topical antibiotic/retinoid preparation and benzoyl peroxide in patients with moderate to severe acne vulgaris. J Drugs Dermatol. 2013 Jun 01; 12(6):619-25.
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Bandyopadhyay M, Kono M, Rohrer B. Explant cultures of Rpe65-/- mouse retina: a model to investigate cone opsin trafficking. Mol Vis. 2013; 19:1149-57.
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Lobo GP, Amengual J, Baus D, Shivdasani RA, Taylor D, von Lintig J. Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX. J Biol Chem. 2013 Mar 29; 288(13):9017-27.