"Amino Acid Substitution" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
| Descriptor ID |
D019943
|
| MeSH Number(s) |
E05.393.420.601.035 G05.558.109
|
| Concept/Terms |
Amino Acid Substitution- Amino Acid Substitution
- Amino Acid Substitutions
- Substitution, Amino Acid
- Substitutions, Amino Acid
|
Below are MeSH descriptors whose meaning is more general than "Amino Acid Substitution".
Below are MeSH descriptors whose meaning is more specific than "Amino Acid Substitution".
This graph shows the total number of publications written about "Amino Acid Substitution" by people in this website by year, and whether "Amino Acid Substitution" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 4 | 4 |
| 2000 | 1 | 6 | 7 |
| 2001 | 0 | 3 | 3 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 6 | 6 |
| 2006 | 0 | 15 | 15 |
| 2007 | 0 | 5 | 5 |
| 2008 | 0 | 12 | 12 |
| 2009 | 0 | 6 | 6 |
| 2010 | 1 | 5 | 6 |
| 2011 | 2 | 6 | 8 |
| 2012 | 0 | 2 | 2 |
| 2013 | 0 | 6 | 6 |
| 2014 | 0 | 4 | 4 |
| 2015 | 1 | 4 | 5 |
| 2016 | 1 | 5 | 6 |
| 2017 | 0 | 5 | 5 |
| 2018 | 0 | 2 | 2 |
| 2019 | 0 | 3 | 3 |
| 2020 | 0 | 2 | 2 |
| 2021 | 0 | 2 | 2 |
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Below are the most recent publications written about "Amino Acid Substitution" by people in Profiles.
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Targeted Therapy for BRAF Mutant Brain Tumors. Curr Treat Options Oncol. 2021 10 06; 22(11):105.
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SAAFEC-SEQ: A Sequence-Based Method for Predicting the Effect of Single Point Mutations on Protein Thermodynamic Stability. Int J Mol Sci. 2021 Jan 09; 22(2).
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Mutations in penicillin-binding protein 2 from cephalosporin-resistant Neisseria gonorrhoeae hinder ceftriaxone acylation by restricting protein dynamics. J Biol Chem. 2020 05 22; 295(21):7529-7543.
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Protease activity in single-chain prekallikrein. Blood. 2020 02 20; 135(8):558-567.
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Characteristics of amino acid substitutions within the "a" determinant region of hepatitis B virus in chronically infected patients with coexisting HBsAg and anti-HBs. Clin Res Hepatol Gastroenterol. 2020 11; 44(6):923-931.
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Uncoupling of p97 ATPase activity has a dominant negative effect on protein extraction. Sci Rep. 2019 07 17; 9(1):10329.
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KRAS G12V Mutation in Acquired Resistance to Combined BRAF and MEK Inhibition in Papillary Thyroid Cancer. J Natl Compr Canc Netw. 2019 05 01; 17(5):409-413.
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Amino acid signatures of HLA Class-I and II molecules are strongly associated with SLE susceptibility and autoantibody production in Eastern Asians. PLoS Genet. 2019 04; 15(4):e1008092.
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Dominant-negative IKZF1 mutations cause a T, B, and myeloid cell combined immunodeficiency. J Clin Invest. 2018 07 02; 128(7):3071-3087.
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A Nonhemolytic Group B Streptococcus Strain Exhibits Hypervirulence. J Infect Dis. 2018 03 05; 217(6):983-987.