"Thymidylate Synthase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme of the transferase class that catalyzes the reaction 5,10-methylenetetrahydrofolate and dUMP to dihydrofolate and dTMP in the synthesis of thymidine triphosphate. (From Dorland, 27th ed) EC 2.1.1.45.
| Descriptor ID |
D013940
|
| MeSH Number(s) |
D08.811.913.555.500.862
|
| Concept/Terms |
Thymidylate Synthase- Thymidylate Synthase
- Synthase, Thymidylate
- Thymidylate Synthetase
- Synthetase, Thymidylate
|
Below are MeSH descriptors whose meaning is more general than "Thymidylate Synthase".
Below are MeSH descriptors whose meaning is more specific than "Thymidylate Synthase".
This graph shows the total number of publications written about "Thymidylate Synthase" by people in this website by year, and whether "Thymidylate Synthase" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 1 | 2 |
| 1997 | 0 | 1 | 1 |
| 1998 | 1 | 0 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 1 | 0 | 1 |
| 2001 | 1 | 1 | 2 |
| 2004 | 2 | 0 | 2 |
| 2005 | 2 | 0 | 2 |
| 2006 | 2 | 0 | 2 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 1 | 2 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 3 | 0 | 3 |
| 2013 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Thymidylate Synthase" by people in Profiles.
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Biomolecular study of human thymidylate synthase conformer-selective inhibitors: New chemotherapeutic approach. PLoS One. 2018; 13(3):e0193810.
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Folate-genetics and colorectal neoplasia: what we know and need to know next. Mol Nutr Food Res. 2013 Apr; 57(4):607-27.
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Expression and regulation of RAD51 mediate cellular responses to chemotherapeutics. Biochem Pharmacol. 2012 Mar 15; 83(6):741-6.
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Evolution of metamorphism in thymidylate synthases within the primate lineages. J Mol Evol. 2011 Mar; 72(3):306-14.
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Human thymidylate synthase with loop 181-197 stabilized in an inactive conformation: ligand interactions, phosphorylation, and inhibition profiles. Protein Sci. 2011 Jan; 20(1):87-94.
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Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability . Biochemistry. 2010 Mar 23; 49(11):2475-82.
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Variants of human thymidylate synthase with loop 181-197 stabilized in the inactive conformation. Protein Sci. 2009 Aug; 18(8):1628-36.
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DNA damage and homologous recombination signaling induced by thymidylate deprivation. Biochem Pharmacol. 2008 Oct 15; 76(8):987-96.
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Induction of intrachromosomal homologous recombination in human cells by raltitrexed, an inhibitor of thymidylate synthase. DNA Repair (Amst). 2008 Oct 01; 7(10):1624-35.
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Uracil incorporation into genomic DNA does not predict toxicity caused by chemotherapeutic inhibition of thymidylate synthase. DNA Repair (Amst). 2008 Feb 01; 7(2):162-9.