"Cholera Toxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells, and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
| Descriptor ID |
D002772
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| MeSH Number(s) |
D08.811.913.400.725.115.180 D23.946.123.194 D23.946.330.150
|
| Concept/Terms |
Cholera Toxin- Cholera Toxin
- Toxin, Cholera
- Cholera Exotoxin
- Exotoxin, Cholera
- Choleragen
- Cholera Enterotoxin CT
- CT, Cholera Enterotoxin
- Enterotoxin CT, Cholera
Choleragenoid- Choleragenoid
- Cholera Toxin Protomer B
- Cholera Toxin B Subunit
|
Below are MeSH descriptors whose meaning is more general than "Cholera Toxin".
Below are MeSH descriptors whose meaning is more specific than "Cholera Toxin".
This graph shows the total number of publications written about "Cholera Toxin" by people in this website by year, and whether "Cholera Toxin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 1 | 2 |
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2007 | 1 | 1 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cholera Toxin" by people in Profiles.
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GRASP55 regulates intra-Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis. EMBO J. 2021 10 18; 40(20):e107766.
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Projections from the subparaventricular zone define four channels of output from the circadian timing system. J Comp Neurol. 2015 Dec 15; 523(18):2714-37.
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Cholera toxin B subunit linked to glutamic acid decarboxylase suppresses dendritic cell maturation and function. Vaccine. 2011 Oct 26; 29(46):8451-8.
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Suppression of dendritic cell activation by diabetes autoantigens linked to the cholera toxin B subunit. Immunobiology. 2011 Apr; 216(4):447-56.
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Membrane mobility and microdomain association of the dopamine transporter studied with fluorescence correlation spectroscopy and fluorescence recovery after photobleaching. Biochemistry. 2007 Sep 18; 46(37):10484-97.
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In vitro induction of immunoglobulin A (IgA)- and IgM-secreting plasma blasts by cholera toxin depends on T-cell help and is mediated by CD154 up-regulation and inhibition of gamma interferon synthesis. Infect Immun. 2007 Mar; 75(3):1413-23.
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Differential binding of Escherichia coli enterotoxins LT-IIa and LT-IIb and of cholera toxin elicits differences in apoptosis, proliferation, and activation of lymphoid cells. Infect Immun. 2005 May; 73(5):2718-27.
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Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms. J Neurosci. 2003 Nov 19; 23(33):10691-702.
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Selective activation of the extended ventrolateral preoptic nucleus during rapid eye movement sleep. J Neurosci. 2002 Jun 01; 22(11):4568-76.
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Afferents to the ventrolateral preoptic nucleus. J Neurosci. 2002 Feb 01; 22(3):977-90.