Core Binding Factor Alpha 2 Subunit

"Core Binding Factor Alpha 2 Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain. Runx1 is frequently mutated in human LEUKEMIAS.

Descriptor ID	D050676
MeSH Number(s)	D12.776.930.155.200.200
Concept/Terms	Core Binding Factor Alpha 2 Subunit Core Binding Factor Alpha 2 Subunit Runx1 Protein Pebp2a2 Protein Runt-Related Transcription Factor 1 Runt Related Transcription Factor 1 Acute Myeloid Leukemia 1 Protein Core-Binding Factor Alpha 2 Protein Core Binding Factor Alpha 2 Protein Acute Myeloid Leukemia 1D Protein Acute Myeloid Leukemia 1D Protein AML1D Protein Acute Myeloid Leukemia 1C Protein Acute Myeloid Leukemia 1C Protein AML1C Protein Acute Myeloid Leukemia 1B Protein Acute Myeloid Leukemia 1B Protein AML1B Protein Acute Myeloid Leukemia 1A Protein Acute Myeloid Leukemia 1A Protein AML1A Protein

Below are MeSH descriptors whose meaning is more general than "Core Binding Factor Alpha 2 Subunit".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Transcription Factors [D12.776.930]
Core Binding Factors [D12.776.930.155]
Core Binding Factor alpha Subunits [D12.776.930.155.200]
Core Binding Factor Alpha 2 Subunit [D12.776.930.155.200.200]

Below are MeSH descriptors whose meaning is related to "Core Binding Factor Alpha 2 Subunit".

Below are MeSH descriptors whose meaning is more specific than "Core Binding Factor Alpha 2 Subunit".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Core Binding Factor Alpha 2 Subunit" by people in this website by year, and whether "Core Binding Factor Alpha 2 Subunit" was a major or minor topic of these publications.

Bar chart showing 13 publications over 12 distinct years, with a maximum of 2 publications in 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2005	0	1	1
2006	2	0	2
2008	0	1	1
2009	1	0	1
2012	1	0	1
2013	1	0	1
2014	0	1	1
2017	1	0	1
2018	0	1	1
2021	1	0	1
2022	1	0	1

Below are the most recent publications written about "Core Binding Factor Alpha 2 Subunit" by people in Profiles.

Gagnon MF, Smadbeck JB, Sharma N, Blackburn PR, Demasi Benevides J, Akkari YMN, Jaroscak JJ, Znoyko I, Wolff DJ, Schandl CA, Meyer R, Greipp PT, Xu X, Hoppman NL, Ketterling RP, Peterson JF, Baughn LB. Apparent coexistence of ETV6::RUNX1 and KMT2A::MLLT3 fusions due to a nonproductive KMT2A rearrangement in B-ALL. Leuk Lymphoma. 2022 Sep; 63(9):2243-2246.

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Mattano LA, Devidas M, Maloney KW, Wang C, Friedmann AM, Buckley P, Borowitz MJ, Carroll AJ, Gastier-Foster JM, Heerema NA, Kadan-Lottick NS, Matloub YH, Marshall DT, Stork LC, Loh ML, Raetz EA, Wood BL, Hunger SP, Carroll WL, Winick NJ. Favorable Trisomies and ETV6-RUNX1 Predict Cure in Low-Risk B-Cell Acute Lymphoblastic Leukemia: Results From Children's Oncology Group Trial AALL0331. J Clin Oncol. 2021 05 10; 39(14):1540-1552.

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Kojo S, Yasmin N, Muroi S, Tenno M, Taniuchi I. Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene. Nat Commun. 2018 09 05; 9(1):3593.

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Nieke S, Yasmin N, Kakugawa K, Yokomizo T, Muroi S, Taniuchi I. Unique N-terminal sequences in two Runx1 isoforms are dispensable for Runx1 function. BMC Dev Biol. 2017 10 18; 17(1):14.

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Rouse M, Rao R, Nagarkatti M, Nagarkatti PS. 3,3'-diindolylmethane ameliorates experimental autoimmune encephalomyelitis by promoting cell cycle arrest and apoptosis in activated T cells through microRNA signaling pathways. J Pharmacol Exp Ther. 2014 Aug; 350(2):341-52.

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Kim DY, Kwon E, Hartley PD, Crosby DC, Mann S, Krogan NJ, Gross JD. CBFß stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. Mol Cell. 2013 Feb 21; 49(4):632-44.

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Yoshimi M, Goyama S, Kawazu M, Nakagawa M, Ichikawa M, Imai Y, Kumano K, Asai T, Mulloy JC, Kraft AS, Takahashi T, Shirafuji N, Kurokawa M. Multiple phosphorylation sites are important for RUNX1 activity in early hematopoiesis and T-cell differentiation. Eur J Immunol. 2012 Apr; 42(4):1044-50.

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Wildey GM, Howe PH. Runx1 is a co-activator with FOXO3 to mediate transforming growth factor beta (TGFbeta)-induced Bim transcription in hepatic cells. J Biol Chem. 2009 Jul 24; 284(30):20227-39.

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McCabe CD, Spyropoulos DD, Martin D, Moreno CS. Genome-wide analysis of the homeobox C6 transcriptional network in prostate cancer. Cancer Res. 2008 Mar 15; 68(6):1988-96.

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Wang S, Zhang Y, Soosairajah J, Kraft AS. Regulation of RUNX1/AML1 during the G2/M transition. Leuk Res. 2007 Jun; 31(6):839-51.

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