Core Binding Factor Alpha 2 Subunit
"Core Binding Factor Alpha 2 Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain. Runx1 is frequently mutated in human LEUKEMIAS.
| Descriptor ID |
D050676
|
| MeSH Number(s) |
D12.776.930.155.200.200
|
| Concept/Terms |
Core Binding Factor Alpha 2 Subunit- Core Binding Factor Alpha 2 Subunit
- Runx1 Protein
- Pebp2a2 Protein
- Runt-Related Transcription Factor 1
- Runt Related Transcription Factor 1
- Acute Myeloid Leukemia 1 Protein
- Core-Binding Factor Alpha 2 Protein
- Core Binding Factor Alpha 2 Protein
|
Below are MeSH descriptors whose meaning is more general than "Core Binding Factor Alpha 2 Subunit".
Below are MeSH descriptors whose meaning is more specific than "Core Binding Factor Alpha 2 Subunit".
This graph shows the total number of publications written about "Core Binding Factor Alpha 2 Subunit" by people in this website by year, and whether "Core Binding Factor Alpha 2 Subunit" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 2 | 0 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Core Binding Factor Alpha 2 Subunit" by people in Profiles.
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Apparent coexistence of ETV6::RUNX1 and KMT2A::MLLT3 fusions due to a nonproductive KMT2A rearrangement in B-ALL. Leuk Lymphoma. 2022 09; 63(9):2243-2246.
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Favorable Trisomies and ETV6-RUNX1 Predict Cure in Low-Risk B-Cell Acute Lymphoblastic Leukemia: Results From Children's Oncology Group Trial AALL0331. J Clin Oncol. 2021 05 10; 39(14):1540-1552.
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Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene. Nat Commun. 2018 09 05; 9(1):3593.
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Unique N-terminal sequences in two Runx1 isoforms are dispensable for Runx1 function. BMC Dev Biol. 2017 10 18; 17(1):14.
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3,3'-diindolylmethane ameliorates experimental autoimmune encephalomyelitis by promoting cell cycle arrest and apoptosis in activated T cells through microRNA signaling pathways. J Pharmacol Exp Ther. 2014 Aug; 350(2):341-52.
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CBF? stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. Mol Cell. 2013 Feb 21; 49(4):632-44.
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Multiple phosphorylation sites are important for RUNX1 activity in early hematopoiesis and T-cell differentiation. Eur J Immunol. 2012 Apr; 42(4):1044-50.
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Runx1 is a co-activator with FOXO3 to mediate transforming growth factor beta (TGFbeta)-induced Bim transcription in hepatic cells. J Biol Chem. 2009 Jul 24; 284(30):20227-39.
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Genome-wide analysis of the homeobox C6 transcriptional network in prostate cancer. Cancer Res. 2008 Mar 15; 68(6):1988-96.
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Regulation of RUNX1/AML1 during the G2/M transition. Leuk Res. 2007 Jun; 31(6):839-51.