"Fibrinolysin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A product of the lysis of plasminogen (profibrinolysin) by PLASMINOGEN activators. It is composed of two polypeptide chains, light (B) and heavy (A), with a molecular weight of 75,000. It is the major proteolytic enzyme involved in blood clot retraction or the lysis of fibrin and quickly inactivated by antiplasmins.
| Descriptor ID |
D005341
|
| MeSH Number(s) |
D08.811.277.656.300.760.330 D08.811.277.656.959.350.330
|
| Concept/Terms |
Fibrinolysin- Fibrinolysin
- Plasmin
- Protease F
- Glu-Plasmin
- Glu Plasmin
|
Below are MeSH descriptors whose meaning is more general than "Fibrinolysin".
Below are MeSH descriptors whose meaning is more specific than "Fibrinolysin".
This graph shows the total number of publications written about "Fibrinolysin" by people in this website by year, and whether "Fibrinolysin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2003 | 0 | 2 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 1 | 2 |
| 2010 | 2 | 1 | 3 |
| 2011 | 1 | 0 | 1 |
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Below are the most recent publications written about "Fibrinolysin" by people in Profiles.
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Continuous localized monitoring of plasmin activity identifies differential and regional effects of the serine protease inhibitor aprotinin: relevance to antifibrinolytic therapy. J Cardiovasc Pharmacol. 2011 Apr; 57(4):400-6.
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Interstitial plasmin activity with epsilon aminocaproic acid: temporal and regional heterogeneity. Ann Thorac Surg. 2010 May; 89(5):1538-45.
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Temporally and regionally disparate differences in plasmin activity by tranexamic acid. Anesth Analg. 2010 Mar 01; 110(3):694-701.
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Treatment of episodes of hereditary angioedema with C1 inhibitor: serial assessment of observed abnormalities of the plasma bradykinin-forming pathway and fibrinolysis. Ann Allergy Asthma Immunol. 2010 Jan; 104(1):50-4.
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Plasmin immunization preferentially induces potentially prothrombotic IgG anticardiolipin antibodies in MRL/MpJ mice. Arthritis Rheum. 2009 Oct; 60(10):3108-17.
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Knockout of plasminogen activator inhibitor 1 gene reduces amyloid beta peptide burden in a mouse model of Alzheimer's disease. Neurobiol Aging. 2011 Jun; 32(6):1079-89.
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Studies of the mechanisms of bradykinin generation in hereditary angioedema plasma. Ann Allergy Asthma Immunol. 2008 Sep; 101(3):279-86.
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Intestinal transformation results in transforming growth factor-beta-dependent alteration in tumor cell-cell matrix interactions. Surgery. 2003 May; 133(5):568-79.
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Changes in extracellular collagen matrix alter myocardial systolic performance. Am J Physiol Heart Circ Physiol. 2003 Jan; 284(1):H122-32.
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Viscoelastic properties of pressure overload hypertrophied myocardium: effect of serine protease treatment. Am J Physiol Heart Circ Physiol. 2002 Jun; 282(6):H2324-35.