"Factor XIIa" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.
| Descriptor ID |
D015956
|
| MeSH Number(s) |
D08.811.277.656.300.760.324 D08.811.277.656.959.350.324 D12.776.124.125.450.324 D23.119.450.324
|
| Concept/Terms |
Factor XIIa- Factor XIIa
- Activated Factor XII
- Factor XII, Activated
- Coagulation Factor XIIa
- Factor XIIa, Coagulation
- Blood Coagulation Factor XII, Activated
- Prekallikrein Activator
- Activator, Prekallikrein
- Factor Twelve A
- Factor 12A
|
Below are MeSH descriptors whose meaning is more general than "Factor XIIa".
Below are MeSH descriptors whose meaning is more specific than "Factor XIIa".
This graph shows the total number of publications written about "Factor XIIa" by people in this website by year, and whether "Factor XIIa" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Factor XIIa" by people in Profiles.
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A novel assay to diagnose hereditary angioedema utilizing inhibition of bradykinin-forming enzymes. Allergy. 2015 Jan; 70(1):115-9.
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Treatment of episodes of hereditary angioedema with C1 inhibitor: serial assessment of observed abnormalities of the plasma bradykinin-forming pathway and fibrinolysis. Ann Allergy Asthma Immunol. 2010 Jan; 104(1):50-4.
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Studies of the mechanisms of bradykinin generation in hereditary angioedema plasma. Ann Allergy Asthma Immunol. 2008 Sep; 101(3):279-86.
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Activation of the bradykinin-forming cascade on endothelial cells: a role for heat shock protein 90. Int Immunopharmacol. 2002 Dec; 2(13-14):1851-9.
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Assembly of the human plasma kinin-forming cascade along the surface of vascular endothelial cells. Int Arch Allergy Immunol. 1995 May-Jun; 107(1-3):93-4.
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Release of elastase from purified human lung mast cells and basophils. Identification as a Hageman factor cleaving enzyme. Inflammation. 1989 Jun; 13(3):295-308.
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The effect of C1 inhibitor upon Hageman factor autoactivation. Blood. 1986 Jul; 68(1):239-43.
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Assessment of Hageman factor activation in human plasma: quantification of activated Hageman factor-C1 inactivator complexes by an enzyme-linked differential antibody immunosorbent assay. Blood. 1985 Sep; 66(3):636-41.
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Mechanisms of activation of the classical pathway of complement by Hageman factor fragment. J Clin Invest. 1983 May; 71(5):1450-6.
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Mechanisms of bradykinin generation in human plasma. Monogr Allergy. 1983; 18:272-6.