"RGS Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A large family of evolutionarily conserved proteins that function as negative regulators of HETEROTRIMERIC GTP-BINDING PROTEINS. RGS PROTEINS act by increasing the GTPase activity of the G alpha subunit of a heterotrimeric GTP-binding protein, causing it to revert to its inactive (GDP-bound) form.
| Descriptor ID |
D020710
|
| MeSH Number(s) |
D12.644.360.325.150.750 D12.776.476.325.150.750
|
| Concept/Terms |
RGS Proteins- RGS Proteins
- Regulators of G-Protein Signaling Proteins
- Regulators of G Protein Signaling Proteins
- RGS Protein (G-Protein Signaling)
|
Below are MeSH descriptors whose meaning is more general than "RGS Proteins".
Below are MeSH descriptors whose meaning is more specific than "RGS Proteins".
This graph shows the total number of publications written about "RGS Proteins" by people in this website by year, and whether "RGS Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 |
| 2007 | 2 | 0 | 2 |
| 2008 | 1 | 0 | 1 |
| 2009 | 2 | 0 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 2 | 0 | 2 |
| 2012 | 2 | 1 | 3 |
| 2013 | 2 | 0 | 2 |
| 2015 | 1 | 0 | 1 |
| 2017 | 1 | 1 | 2 |
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Below are the most recent publications written about "RGS Proteins" by people in Profiles.
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Regulator of G protein signaling 2 is a key regulator of pancreatic ?-cell mass and function. Cell Death Dis. 2017 05 25; 8(5):e2821.
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Regulation of Chemokine Signal Integration by Activator of G-Protein Signaling 4 (AGS4). J Pharmacol Exp Ther. 2017 03; 360(3):424-433.
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Bioluminescence resonance energy transfer to detect protein-protein interactions in live cells. Methods Mol Biol. 2015; 1278:457-65.
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Normal autophagic activity in macrophages from mice lacking Gai3, AGS3, or RGS19. PLoS One. 2013; 8(11):e81886.
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Transcriptional suppression, DNA methylation, and histone deacetylation of the regulator of G-protein signaling 10 (RGS10) gene in ovarian cancer cells. PLoS One. 2013; 8(3):e60185.
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Assembly and function of the regulator of G protein signaling 14 (RGS14)?H-Ras signaling complex in live cells are regulated by Gai1 and Gai-linked G protein-coupled receptors. J Biol Chem. 2013 Feb 01; 288(5):3620-31.
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Regulation of the G-protein regulatory-Gai signaling complex by nonreceptor guanine nucleotide exchange factors. J Biol Chem. 2013 Feb 01; 288(5):3003-15.
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Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses. Behav Brain Funct. 2012 May 16; 8:23.
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RGS4 overexpression in the rat dorsal striatum modulates mGluR5- and amphetamine-mediated behavior and signaling. Psychopharmacology (Berl). 2012 Jun; 221(4):621-35.
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G protein-coupled receptors and resistance to inhibitors of cholinesterase-8A (Ric-8A) both regulate the regulator of g protein signaling 14 RGS14?Gai1 complex in live cells. J Biol Chem. 2011 Nov 04; 286(44):38659-38669.