"Buthionine Sulfoximine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)
| Descriptor ID |
D019328
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| MeSH Number(s) |
D02.886.030.676.620.125 D12.125.166.676.620.125
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Buthionine Sulfoximine".
Below are MeSH descriptors whose meaning is more specific than "Buthionine Sulfoximine".
This graph shows the total number of publications written about "Buthionine Sulfoximine" by people in this website by year, and whether "Buthionine Sulfoximine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1997 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
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Below are the most recent publications written about "Buthionine Sulfoximine" by people in Profiles.
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Manganese potentiates in vitro production of proinflammatory cytokines and nitric oxide by microglia through a nuclear factor kappa B-dependent mechanism. Toxicol Sci. 2005 Mar; 84(1):139-48.
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Phase I study of continuous-infusion L-S,R-buthionine sulfoximine with intravenous melphalan. J Natl Cancer Inst. 1997 Dec 03; 89(23):1789-96.
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Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione. J Biol Chem. 1997 Jun 27; 272(26):16281-7.
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Modulation of glutathione and related enzymes in reversal of resistance to anticancer drugs. Hematol Oncol Clin North Am. 1995 Apr; 9(2):383-96.
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Depletion of glutathione in normal and malignant human cells in vivo by buthionine sulfoximine: clinical and biochemical results. J Natl Cancer Inst. 1992 Feb 19; 84(4):264-7.
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Role of glutathione in the in vitro synergism between 4-hydroperoxy-cyclophosphamide and cisplatin in leukemia cell lines. Cancer Res. 1991 May 15; 51(10):2536-41.
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Cellular glutathione as a protective agent against 4-hydroperoxycyclophosphamide cytotoxicity in K-562 cells. Cancer Chemother Pharmacol. 1990; 26(6):397-402.
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Relationship of glutathione depletion and inhibition of glutathione-S-transferase activity to the antimitotic properties of estramustine. Cancer Treat Rep. 1986 Jun; 70(6):715-20.