"Papaverine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
| Descriptor ID |
D010208
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| MeSH Number(s) |
D03.132.098.666 D03.132.577.750 D03.633.100.531.085.666
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Papaverine".
Below are MeSH descriptors whose meaning is more specific than "Papaverine".
This graph shows the total number of publications written about "Papaverine" by people in this website by year, and whether "Papaverine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2006 | 1 | 1 | 2 |
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Below are the most recent publications written about "Papaverine" by people in Profiles.
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Feasibility of vitrification as a storage method for tissue-engineered blood vessels. Tissue Eng. 2006 Feb; 12(2):291-300.
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Intra-arterial papaverine used to treat cerebral vasospasm reduces brain oxygen. Neurocrit Care. 2006; 4(2):113-8.
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Papaverine delivery to the internal mammary artery pedicle effectively treats spasm. Ann Thorac Surg. 2004 Oct; 78(4):1295-8.
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Glucose regulation of guinea-pig sperm motility. J Reprod Fertil. 1991 May; 92(1):75-87.
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Human platelets modulate edema formation in isolated rabbit lungs. J Clin Invest. 1989 Sep; 84(3):757-64.
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Interaction of aortic pressure and left ventricular end-diastolic pressure in the dog. Am J Physiol. 1977 Jun; 232(6):H697-704.
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Alcohol addiction and tetrahydropapaveroline. Science. 1970 Sep 11; 169(3950):1104-5.
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Does tetrahydroparaveroline contribute to the cardiovascular actions of dopamine? Biochem Pharmacol. 1968 Sep; 17(9):1873-80.