"Bicuculline" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors.
| Descriptor ID |
D001640
|
| MeSH Number(s) |
D03.132.098.077 D03.633.100.531.085.077
|
| Concept/Terms |
Bicuculline- Bicuculline
- 6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)furo(3,4-e)1,3-benzodioxol-8(6H)one
|
Below are MeSH descriptors whose meaning is more general than "Bicuculline".
Below are MeSH descriptors whose meaning is more specific than "Bicuculline".
This graph shows the total number of publications written about "Bicuculline" by people in this website by year, and whether "Bicuculline" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Bicuculline" by people in Profiles.
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Repeated toluene exposure increases the excitability of layer 5 pyramidal neurons in the prefrontal cortex of adolescent rats. Neurotoxicol Teratol. 2018 Jul - Aug; 68:27-35.
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Ethanol reduces neuronal excitability of lateral orbitofrontal cortex neurons via a glycine receptor dependent mechanism. Neuropsychopharmacology. 2013 Jun; 38(7):1176-88.
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The infralimbic cortex regulates the consolidation of extinction after cocaine self-administration. Learn Mem. 2010 Apr; 17(4):168-75.
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Effects of the beta-amino acid antagonist TAG on thalamocortical inhibition. Neuropharmacology. 2009 Jun; 56(8):1097-105.
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Neuregulin blocks synaptic strengthening after epileptiform activity in the rat hippocampus. Brain Res. 2008 May 07; 1208:67-73.
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NAC1 regulates the recruitment of the proteasome complex into dendritic spines. J Neurosci. 2007 Aug 15; 27(33):8903-13.
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Mesocortical dopamine neurons operate in distinct temporal domains using multimodal signaling. J Neurosci. 2005 May 18; 25(20):5013-23.
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Alterations in glutamatergic and gabaergic ion channel activity in hippocampal neurons following exposure to the abused inhalant toluene. Neuroscience. 2005; 130(1):197-206.
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Chronic ethanol induces synaptic but not extrasynaptic targeting of NMDA receptors. J Neurosci. 2004 Sep 08; 24(36):7859-68.
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Intrastriatal GABA(A) receptor blockade does not alter dopamine D(1)/D(2) receptor interactions in the intact rat striatum. Neuroscience. 2001; 102(2):381-9.