Pteroylpolyglutamic Acids
"Pteroylpolyglutamic Acids" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Derivatives of folic acid (pteroylglutamic acid). In gamma-glutamyl linkage they are found in many tissues. They are converted to folic acid by the action of pteroylpolyglutamate hydrolase or synthesized from folic acid by the action of folate polyglutamate synthetase. Synthetic pteroylpolyglutamic acids, which are in alpha-glutamyl linkage, are active in bacterial growth assays.
| Descriptor ID |
D011624
|
| MeSH Number(s) |
D03.633.100.733.631.400.600
|
| Concept/Terms |
Folate Polyglutamates- Folate Polyglutamates
- Polyglutamates, Folate
- Polyglutamate Folates
- Folates, Polyglutamate
- Pteroylpolyglutamates
|
Below are MeSH descriptors whose meaning is more general than "Pteroylpolyglutamic Acids".
Below are MeSH descriptors whose meaning is more specific than "Pteroylpolyglutamic Acids".
This graph shows the total number of publications written about "Pteroylpolyglutamic Acids" by people in this website by year, and whether "Pteroylpolyglutamic Acids" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pteroylpolyglutamic Acids" by people in Profiles.
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Multiple mechanisms of resistance to polyglutamatable and lipophilic antifolates in mammalian cells: role of increased folylpolyglutamylation, expanded folate pools, and intralysosomal drug sequestration. Mol Pharmacol. 1999 Apr; 55(4):761-9.
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Role of folylpolyglutamates in biochemical modulation of fluoropyrimidines by leucovorin. Cancer Res. 1991 Feb 01; 51(3):789-93.
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Role of substrate depletion in the inhibition of thymidylate biosynthesis by the dihydrofolate reductase inhibitor trimetrexate in cultured hepatoma cells. Cancer Res. 1990 Jul 01; 50(13):3979-84.
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The role of folylpolyglutamate synthetase and gamma-glutamyl hydrolase in altering cellular folyl- and antifolylpolyglutamates. Adv Enzyme Regul. 1987; 26:147-55.
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Effects of growth rate and methotrexate on folate polyglutamates and folylpolyglutamate hydrolase activity in Krebs ascites cells. Biochem Cell Biol. 1986 Apr; 64(4):363-7.
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Tissue folate polyglutamate chain length determination by electrophoresis as thymidylate synthase-fluorodeoxyuridylate ternary complexes. Methods Enzymol. 1986; 122:313-9.
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Determination of mouse liver 5-methyltetrahydrofolate concentration and polyglutamate forms. J Biochem Biophys Methods. 1985 Mar; 10(5-6):287-94.
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Evaluation of folylpolyglutamates by electrophoretic separation of fluorodeoxyuridylate-thymidylate synthase-methylenetetrahydrofolate complexes. Adv Exp Med Biol. 1983; 163:139-48.
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Cell cycle patterns of thymidylate synthetase and 5,10-methylenetetrahydrofolate polyglutamates in cultured mouse hepatoma cells. Experientia. 1982 Jan 15; 38(1):88-9.
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Tissue folylpolyglutamate chain-length characterization by electrophoresis as thymidylate synthetase-fluorodeoxyuridylate ternary complexes. Anal Biochem. 1981 Jul 15; 115(1):163-9.