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Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase.

Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase. Mol Cancer Ther. 2018 12; 17(12):2710-2721.

View in: PubMed

subject areas
  • Animals
  • Cell Line, Tumor
  • Cell Proliferation
  • Cell Survival
  • Drug Resistance, Neoplasm
  • Drug Synergism
  • Glutathione
  • Humans
  • Male
  • Mice, SCID
  • NF-E2-Related Factor 2
  • Oxidation-Reduction
  • Phosphatidylinositol 3-Kinases
  • Protein Kinase Inhibitors
  • Protein Stability
  • Proto-Oncogene Proteins c-akt
  • Proto-Oncogene Proteins c-pim-1
  • Reactive Oxygen Species
  • Ubiquitination
  • Up-Regulation

authors with profiles
  • Andrew S Kraft