Parathyroid Hormone-Related Protein
"Parathyroid Hormone-Related Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It does not circulate in appreciable amounts in normal subjects, but rather exerts its biological actions locally. Overexpression of parathyroid hormone-related protein by tumor cells results in humoral calcemia of malignancy.
| Descriptor ID |
D044162
|
| MeSH Number(s) |
D06.472.699.591 D12.644.276.908 D12.644.548.588 D12.776.467.890 D23.529.890
|
| Concept/Terms |
Parathyroid Hormone-Related Protein- Parathyroid Hormone-Related Protein
- Hormone-Related Protein, Parathyroid
- Parathyroid Hormone Related Protein
- Parathyroid Hormone-Like Protein
- Parathyroid Hormone Like Protein
- Parathyroid Hormone-Related Peptide
- Parathyroid Hormone Related Peptide
- PTHrP
- Tumor Hypercalcemic Factor
- Hypercalcemic Factor, Tumor
- Hypercalcemic Hormone of Malignancy
- PTH Like Tumor Factor
- PTH-Like Protein
- PTH Like Protein
- Parathyroid Hormone Like Tumor Factor
- PTH-Related Peptide
- PTH Related Peptide
|
Below are MeSH descriptors whose meaning is more general than "Parathyroid Hormone-Related Protein".
Below are MeSH descriptors whose meaning is more specific than "Parathyroid Hormone-Related Protein".
This graph shows the total number of publications written about "Parathyroid Hormone-Related Protein" by people in this website by year, and whether "Parathyroid Hormone-Related Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 2 | 0 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 2 | 0 | 2 |
| 2011 | 1 | 1 | 2 |
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Below are the most recent publications written about "Parathyroid Hormone-Related Protein" by people in Profiles.
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A 7-day continuous infusion of PTH or PTHrP suppresses bone formation and uncouples bone turnover. J Bone Miner Res. 2011 Sep; 26(9):2287-97.
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Severe hypercalcemia associated with uterine leiomyoma in pregnancy. Obstet Gynecol. 2011 Feb; 117(2 Pt 2):473-476.
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The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice. FASEB J. 2010 Jun; 24(6):1947-57.
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Parathyroid hormone-related protein for the treatment of postmenopausal osteoporosis: defining the maximal tolerable dose. J Clin Endocrinol Metab. 2010 Mar; 95(3):1279-87.
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Osteoclasts are important for bone angiogenesis. Blood. 2010 Jan 07; 115(1):140-9.
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Transcriptional regulation of parathyroid hormone-related protein promoter P2 by NF-kappaB in adult T-cell leukemia/lymphoma. Leukemia. 2007 Aug; 21(8):1752-62.
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Osteoprotegerin overexpression by breast cancer cells enhances orthotopic and osseous tumor growth and contrasts with that delivered therapeutically. Cancer Res. 2006 Apr 01; 66(7):3620-8.
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Safety and tolerability of subcutaneous PTHrP(1-36) in healthy human volunteers: a dose escalation study. Osteoporos Int. 2006 Feb; 17(2):225-30.
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Continuous PTH and PTHrP infusion causes suppression of bone formation and discordant effects on 1,25(OH)2 vitamin D. J Bone Miner Res. 2005 Oct; 20(10):1792-803.
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Transitional cell carcinoma of the bladder producing parathyroid hormone-related protein (PTHrP). Can J Urol. 2004 Feb; 11(1):2136-8.