Topoisomerase II Inhibitors
"Topoisomerase II Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.
| Descriptor ID |
D059005
|
| MeSH Number(s) |
D27.505.519.389.892.750 D27.505.954.248.794.750
|
| Concept/Terms |
Topoisomerase II Inhibitors- Topoisomerase II Inhibitors
- Inhibitors, Topoisomerase II
- DNA Type 2 Topoisomerase Inhibitors
- Topoisomerase 2 Inhibitors
- Inhibitors, Topoisomerase 2
- DNA Topoisomerase II Inhibitors
|
Below are MeSH descriptors whose meaning is more general than "Topoisomerase II Inhibitors".
Below are MeSH descriptors whose meaning is more specific than "Topoisomerase II Inhibitors".
This graph shows the total number of publications written about "Topoisomerase II Inhibitors" by people in this website by year, and whether "Topoisomerase II Inhibitors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "Topoisomerase II Inhibitors" by people in Profiles.
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Expression and regulation of RAD51 mediate cellular responses to chemotherapeutics. Biochem Pharmacol. 2012 Mar 15; 83(6):741-6.
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Merbarone induces activation of caspase-activated DNase and excision of chromosomal DNA loops from the nuclear matrix. Mol Pharmacol. 2006 Apr; 69(4):1477-85.
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Arrest of replication fork progression at sites of topoisomerase II-mediated DNA cleavage in human leukemia CEM cells incubated with VM-26. Biochemistry. 1997 May 13; 36(19):5739-48.
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DNA topoisomerase II isozymes involved in anticancer drug action and resistance. Adv Enzyme Regul. 1995; 35:265-81.
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Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNA. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3231-5.