"Pyrin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tripartite motif protein that consists of an N-terminal pyrin domain, a central coiled-coil region and B-box type ZINC FINGER, and C-terminal regions that mediate homotrimerization and interactions with other proteins (the B30.2/SPRY DOMAIN). It is expressed primarily by mature GRANULOCYTES and associates with the cytoskeleton in the perinuclear area as well as AUTOPHAGOSOMES, where it co-ordinates the assembly of AUTOPHAGY-RELATED PROTEINS and degradation of INFLAMMASOME components. It functions in INNATE IMMUNITY and INFLAMMATION; mutations in the Pyrin protein (MEFV) gene are associated with FAMILIAL MEDITERRANEAN FEVER.
| Descriptor ID |
D000071198
|
| MeSH Number(s) |
D12.776.220.909 D12.776.934.750
|
| Concept/Terms |
Pyrin- Pyrin
- MEFV Protein
- TRIM20 Protein
- Mediterranean Fever Protein
- Marenostrin
|
Below are MeSH descriptors whose meaning is more general than "Pyrin".
Below are MeSH descriptors whose meaning is more specific than "Pyrin".
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Below are the most recent publications written about "Pyrin" by people in Profiles.