Adenomatous Polyposis Coli Protein
"Adenomatous Polyposis Coli Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A negative regulator of beta-catenin signaling which is mutant in ADENOMATOUS POLYPOSIS COLI and GARDNER SYNDROME.
| Descriptor ID |
D025601
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| MeSH Number(s) |
D05.500.117.249 D12.776.220.040 D12.776.476.081.249 D12.776.624.776.010
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Adenomatous Polyposis Coli Protein".
Below are MeSH descriptors whose meaning is more specific than "Adenomatous Polyposis Coli Protein".
This graph shows the total number of publications written about "Adenomatous Polyposis Coli Protein" by people in this website by year, and whether "Adenomatous Polyposis Coli Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 2 | 1 | 3 |
| 2014 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Adenomatous Polyposis Coli Protein" by people in Profiles.
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Mutant APC promotes tumor immune evasion via PD-L1 in colorectal cancer. Oncogene. 2021 10; 40(41):5984-5992.
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Antibiotic-mediated bacteriome depletion in ApcMin/+ mice is associated with reduction in mucus-producing goblet cells and increased colorectal cancer progression. Cancer Med. 2018 05; 7(5):2003-2012.
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5-Fluorouracil mediated anti-cancer activity in colon cancer cells is through the induction of Adenomatous Polyposis Coli: Implication of the long-patch base excision repair pathway. DNA Repair (Amst). 2014 Dec; 24:15-25.
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Expression of ROR?t marks a pathogenic regulatory T cell subset in human colon cancer. Sci Transl Med. 2012 Dec 12; 4(164):164ra159.
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Lycopene synergistically enhances quinacrine action to inhibit Wnt-TCF signaling in breast cancer cells through APC. Carcinogenesis. 2013 Feb; 34(2):277-86.
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Chronic epithelial NF-?B activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14007-12.
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Adenomatous polyposis coli (APC) regulates multiple signaling pathways by enhancing glycogen synthase kinase-3 (GSK-3) activity. J Biol Chem. 2012 Feb 03; 287(6):3823-32.
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Intestinal inflammatory cytokine response in relation to tumorigenesis in the Apc(Min/+) mouse. Cytokine. 2012 Jan; 57(1):113-9.
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Brain tumors in individuals with familial adenomatous polyposis: a cancer registry experience and pooled case report analysis. Cancer. 2007 Feb 15; 109(4):761-6.
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Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth. Nat Med. 2004 Mar; 10(3):245-7.