NLR Family, Pyrin Domain-Containing 3 Protein
"NLR Family, Pyrin Domain-Containing 3 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An NLR protein that contains an N-terminal PYRIN DOMAIN and ATP-binding site and 9 C-terminal LEUCINE-rich repeats; it is expressed primarily by MACROPHAGES. It is a core component of the INFLAMMASOME and directs its assembly in response to pathogen infection and damage-associated stimuli. Mutations in the NLRP3 gene are associated with FAMILIAL COLD AUTOINFLAMMATORY SYNDROME.
| Descriptor ID |
D000071199
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| MeSH Number(s) |
D12.644.360.539.250
|
| Concept/Terms |
NLR Family, Pyrin Domain-Containing 3 Protein- NLR Family, Pyrin Domain-Containing 3 Protein
- NLR Family, Pyrin Domain Containing 3 Protein
- Cold Autoinflammatory Syndrome 1 Protein
- NACHT, LRR and PYD Domains-Containing Protein 3
- NACHT, LRR and PYD Domains Containing Protein 3
- NLRP3 Protein
|
Below are MeSH descriptors whose meaning is more general than "NLR Family, Pyrin Domain-Containing 3 Protein".
Below are MeSH descriptors whose meaning is more specific than "NLR Family, Pyrin Domain-Containing 3 Protein".
This graph shows the total number of publications written about "NLR Family, Pyrin Domain-Containing 3 Protein" by people in this website by year, and whether "NLR Family, Pyrin Domain-Containing 3 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2016 | 1 | 1 | 2 |
| 2017 | 2 | 0 | 2 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 2 | 3 |
| 2020 | 0 | 2 | 2 |
| 2021 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "NLR Family, Pyrin Domain-Containing 3 Protein" by people in Profiles.
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Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation. Cell Rep. 2023 01 31; 42(1):111941.
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Environmental Microcystin exposure in underlying NAFLD-induced exacerbation of neuroinflammation, blood-brain barrier dysfunction, and neurodegeneration are NLRP3 and S100B dependent. Toxicology. 2021 09; 461:152901.
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Early microcystin-LR exposure-linked inflammasome activation in mice causes development of fatty liver disease and insulin resistance. Environ Toxicol Pharmacol. 2020 Nov; 80:103457.
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Minocycline prevents neuronal hyperexcitability and neuroinflammation in medial prefrontal cortex, as well as memory impairment caused by repeated toluene inhalation in adolescent rats. Toxicol Appl Pharmacol. 2020 05 15; 395:114980.
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NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia. Pharmacol Res. 2019 04; 142:237-250.
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Protein kinase D mediates inflammatory responses of human placental macrophages to Group B Streptococcus. Am J Reprod Immunol. 2019 03; 81(3):e13075.
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Acid sphingomyelinase deficiency protects mitochondria and improves function recovery after brain injury. J Lipid Res. 2019 03; 60(3):609-623.
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Elevated hydrostatic pressure stimulates ATP release which mediates activation of the NLRP3 inflammasome via P2X4 in rat urothelial cells. Int Urol Nephrol. 2018 Sep; 50(9):1607-1617.
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NLRX1 modulates differentially NLRP3 inflammasome activation and NF-?B signaling during Fusobacterium nucleatum infection. Microbes Infect. 2018 Oct - Nov; 20(9-10):615-625.
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Mir-155 is overexpressed in systemic sclerosis fibroblasts and is required for NLRP3 inflammasome-mediated collagen synthesis during fibrosis. Arthritis Res Ther. 2017 06 17; 19(1):144.