"X-Box Binding Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A basic leucine zipper transcription factor that regulates expression of MHC CLASS II GENES through its binding to a conserved X-box DNA sequence in the promoter region. It regulates the expression of genes involved in the UNFOLDED PROTEIN RESPONSE.
| Descriptor ID |
D000071717
|
| MeSH Number(s) |
D12.776.260.108.937 D12.776.930.127.937
|
| Concept/Terms |
X-Box Binding Protein 1- X-Box Binding Protein 1
- X Box Binding Protein 1
- TREB5 Protein
- Tax-Responsive Element-Binding Protein 5
- Tax Responsive Element Binding Protein 5
- XBP-1 Protein
- XBP 1 Protein
- TREB-5 Protein
- TREB 5 Protein
- XBP2 Protein
|
Below are MeSH descriptors whose meaning is more general than "X-Box Binding Protein 1".
Below are MeSH descriptors whose meaning is more specific than "X-Box Binding Protein 1".
This graph shows the total number of publications written about "X-Box Binding Protein 1" by people in this website by year, and whether "X-Box Binding Protein 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2012 | 0 | 3 | 3 |
| 2013 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "X-Box Binding Protein 1" by people in Profiles.
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An XBP1s-PIM-2 positive feedback loop controls IL-15-mediated survival of natural killer cells. Sci Immunol. 2023 03 17; 8(81):eabn7993.
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Mechanisms of liver injury in high fat sugar diet fed mice that lack hepatocyte X-box binding protein 1. PLoS One. 2022; 17(1):e0261789.
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XBP-1s Promotes B Cell Pathogenicity in Chronic GVHD by Restraining the Activity of Regulated IRE-1a-Dependent Decay. Front Immunol. 2021; 12:705484.
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Inhibition of the IRE-1a/XBP-1 pathway prevents chronic GVHD and preserves the GVL effect in mice. Blood Adv. 2018 02 27; 2(4):414-427.
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Molecular chaperone gp96 is a novel therapeutic target of multiple myeloma. Clin Cancer Res. 2013 Nov 15; 19(22):6242-51.
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p53 antagonizes the unfolded protein response and inhibits ground glass hepatocyte development during endoplasmic reticulum stress. Exp Biol Med (Maywood). 2012 Oct; 237(10):1173-80.
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SLC33A1/AT-1 protein regulates the induction of autophagy downstream of IRE1/XBP1 pathway. J Biol Chem. 2012 Aug 24; 287(35):29921-30.
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ERLIN2 promotes breast cancer cell survival by modulating endoplasmic reticulum stress pathways. BMC Cancer. 2012 Jun 08; 12:225.
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FFA-induced adipocyte inflammation and insulin resistance: involvement of ER stress and IKK? pathways. Obesity (Silver Spring). 2011 Mar; 19(3):483-91.
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Compartmentalized expression of three novel sarco/endoplasmic reticulum Ca2+ATPase 3 isoforms including the switch to ER stress, SERCA3f, in non-failing and failing human heart. Cell Calcium. 2009 Feb; 45(2):144-54.