"NADPH Oxidase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An NADPH oxidase that is expressed by PHAGOCYTES where it transfers electrons across the plasma membrane from cytosolic NADPH to molecular oxygen on the exterior. It regulates proton (H+) flux into resting phagocytes to control intracellular pH. Mutations in the CYBB gene are associated with X-LINKED CHRONIC GRANULOMATOUS DISEASE.
| Descriptor ID |
D000074662
|
| MeSH Number(s) |
D08.811.682.608.575.875 D12.776.331.894.875 D12.776.543.653.875
|
| Concept/Terms |
NADPH Oxidase 2- NADPH Oxidase 2
- Oxidase 2, NADPH
- Chronic Granulomatous Disease Protein
- GP91-PHOX Protein
- GP91 PHOX Protein
- CYBB Protein
- Cytochrome B-245 Beta Chain
- Cytochrome B 245 Beta Chain
- NOX2 Protein
|
Below are MeSH descriptors whose meaning is more general than "NADPH Oxidase 2".
Below are MeSH descriptors whose meaning is more specific than "NADPH Oxidase 2".
This graph shows the total number of publications written about "NADPH Oxidase 2" by people in this website by year, and whether "NADPH Oxidase 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 3 | 3 |
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 2 | 1 | 3 |
| 2020 | 1 | 1 | 2 |
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Below are the most recent publications written about "NADPH Oxidase 2" by people in Profiles.
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Higher intestinal and circulatory lactate associated NOX2 activation leads to an ectopic fibrotic pathology following microcystin co-exposure in murine fatty liver disease. Comp Biochem Physiol C Toxicol Pharmacol. 2020 Dec; 238:108854.
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Cancer-Associated Fibroblasts Promote Immunosuppression by Inducing ROS-Generating Monocytic MDSCs in Lung Squamous Cell Carcinoma. Cancer Immunol Res. 2020 04; 8(4):436-450.
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Microglia morphology and proinflammatory signaling in the nucleus accumbens during nicotine withdrawal. Sci Adv. 2019 10; 5(10):eaax7031.
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Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21. Am J Physiol Gastrointest Liver Physiol. 2019 10 01; 317(4):G408-G428.
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Environmental microcystin targets the microbiome and increases the risk of intestinal inflammatory pathology via NOX2 in underlying murine model of Nonalcoholic Fatty Liver Disease. Sci Rep. 2019 06 19; 9(1):8742.
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High circulatory leptin mediated NOX-2-peroxynitrite-miR21 axis activate mesangial cells and promotes renal inflammatory pathology in nonalcoholic fatty liver disease. Redox Biol. 2018 07; 17:1-15.
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Nox4 contributes to the hypoxia-mediated regulation of actin cytoskeleton in cerebrovascular smooth muscle. Life Sci. 2016 Oct 15; 163:46-54.
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Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity. J Lipid Res. 2015 Mar; 56(3):546-561.
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Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol. 2015 Feb 15; 308(4):G298-312.
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Nox2-derived superoxide contributes to cerebral vascular dysfunction in diet-induced obesity. Stroke. 2013 Nov; 44(11):3195-201.