"Pyrimethamine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the FOLIC ACID ANTAGONISTS that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.
| Descriptor ID |
D011739
|
| MeSH Number(s) |
D03.383.742.675
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Pyrimethamine".
Below are MeSH descriptors whose meaning is more specific than "Pyrimethamine".
This graph shows the total number of publications written about "Pyrimethamine" by people in this website by year, and whether "Pyrimethamine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pyrimethamine" by people in Profiles.
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Multiple mechanisms of resistance to polyglutamatable and lipophilic antifolates in mammalian cells: role of increased folylpolyglutamylation, expanded folate pools, and intralysosomal drug sequestration. Mol Pharmacol. 1999 Apr; 55(4):761-9.
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A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance. J Biol Chem. 1998 Nov 13; 273(46):30189-98.
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The role of cellular folates in the enhancement of activity of the thymidylate synthase inhibitor 10-propargyl-5,8-dideazafolate against hepatoma cells in vitro by inhibitors of dihydrofolate reductase. J Biol Chem. 1989 Jun 25; 264(18):10685-92.