"Xanthine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A purine base found in most body tissues and fluids, certain plants, and some urinary calculi. It is an intermediate in the degradation of adenosine monophosphate to uric acid, being formed by oxidation of hypoxanthine. The methylated xanthine compounds caffeine, theobromine, and theophylline and their derivatives are used in medicine for their bronchodilator effects. (Dorland, 28th ed)
| Descriptor ID |
D019820
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| MeSH Number(s) |
D03.132.960.938 D03.633.100.759.758.824.938
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Xanthine".
Below are MeSH descriptors whose meaning is more specific than "Xanthine".
This graph shows the total number of publications written about "Xanthine" by people in this website by year, and whether "Xanthine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2008 | 1 | 1 | 2 |
| 2010 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Xanthine" by people in Profiles.
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Specificity and catalytic mechanism in family 5 uracil DNA glycosylase. J Biol Chem. 2014 Jun 27; 289(26):18413-26.
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Identification of Escherichia coli mismatch-specific uracil DNA glycosylase as a robust xanthine DNA glycosylase. J Biol Chem. 2010 Dec 31; 285(53):41483-90.
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Repair of deaminated base damage by Schizosaccharomyces pombe thymine DNA glycosylase. DNA Repair (Amst). 2008 Dec 01; 7(12):1962-72.
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Insights from xanthine and uracil DNA glycosylase activities of bacterial and human SMUG1: switching SMUG1 to UDG. J Mol Biol. 2009 Jan 23; 385(3):761-78.
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Oxanine DNA glycosylase activity from Mammalian alkyladenine glycosylase. J Biol Chem. 2004 Sep 10; 279(37):38177-83.
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Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by oxidative stress. Biochem J. 2002 12 01; 368(Pt 2):471-81.
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When does the lung die? Time course of high energy phosphate depletion and relationship to lung viability after "death". J Surg Res. 1995 Oct; 59(4):468-74.
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Hydrogen peroxide is the most toxic oxygen species for Onchocerca cervicalis microfilariae. Parasitology. 1990 Jun; 100 Pt 3:407-15.
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Role of purines and xanthine oxidase in reperfusion injury in perfused rat liver. J Pharmacol Exp Ther. 1989 Aug; 250(2):470-5.
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Xanthine and hypoxanthine accumulation during storage may contribute to reperfusion injury following liver transplantation in the rat. Transplant Proc. 1989 Feb; 21(1 Pt 2):1319-20.