Voltage-Dependent Anion Channels
"Voltage-Dependent Anion Channels" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of voltage-gated eukaryotic porins that form aqueous channels. They play an essential role in mitochondrial CELL MEMBRANE PERMEABILITY, are often regulated by BCL-2 PROTO-ONCOGENE PROTEINS, and have been implicated in APOPTOSIS.
| Descriptor ID |
D050994
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| MeSH Number(s) |
D12.776.157.530.400.500.520 D12.776.543.550.450.730.520 D12.776.543.585.400.730.520
|
| Concept/Terms |
Voltage-Dependent Anion Channels- Voltage-Dependent Anion Channels
- Anion Channels, Voltage-Dependent
- Voltage Dependent Anion Channels
- VDAC Proteins
- Pore Forming Protein VDAC
- Voltage-Dependent, Anion-Selective Channels
- Anion-Selective Channels Voltage-Dependent
- Channels Voltage-Dependent, Anion-Selective
- Voltage Dependent, Anion Selective Channels
|
Below are MeSH descriptors whose meaning is more general than "Voltage-Dependent Anion Channels".
Below are MeSH descriptors whose meaning is more specific than "Voltage-Dependent Anion Channels".
This graph shows the total number of publications written about "Voltage-Dependent Anion Channels" by people in this website by year, and whether "Voltage-Dependent Anion Channels" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2010 | 2 | 0 | 2 |
| 2011 | 2 | 0 | 2 |
| 2012 | 1 | 1 | 2 |
| 2013 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 0 | 2 | 2 |
| 2018 | 2 | 0 | 2 |
| 2019 | 2 | 0 | 2 |
| 2022 | 0 | 2 | 2 |
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Below are the most recent publications written about "Voltage-Dependent Anion Channels" by people in Profiles.
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Restricting a-synuclein transport into mitochondria by inhibition of a-synuclein-VDAC complexation as a potential therapeutic target for Parkinson's disease treatment. Cell Mol Life Sci. 2022 Jun 19; 79(7):368.
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Small molecules targeting the NADH-binding pocket of VDAC modulate mitochondrial metabolism in hepatocarcinoma cells. Biomed Pharmacother. 2022 Jun; 150:112928.
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JNK activation and translocation to mitochondria mediates mitochondrial dysfunction and cell death induced by VDAC opening and sorafenib in hepatocarcinoma cells. Biochem Pharmacol. 2020 01; 171:113728.
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Probing Membrane Association of a-Synuclein Domains with VDAC Nanopore Reveals Unexpected Binding Pattern. Sci Rep. 2019 03 14; 9(1):4580.
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Sequence diversity of tubulin isotypes in regulation of the mitochondrial voltage-dependent anion channel. J Biol Chem. 2018 07 13; 293(28):10949-10962.
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VDAC Regulation: A Mitochondrial Target to Stop Cell Proliferation. Adv Cancer Res. 2018; 138:41-69.
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Opening of voltage dependent anion channels promotes reactive oxygen species generation, mitochondrial dysfunction and cell death in cancer cells. Biochem Pharmacol. 2018 02; 148:155-162.
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Erastin-Like Anti-Warburg Agents Prevent Mitochondrial Depolarization Induced by Free Tubulin and Decrease Lactate Formation in Cancer Cells. SLAS Discov. 2018 01; 23(1):23-33.
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Combined effect of G3139 and TSPO ligands on Ca(2+)-induced permeability transition in rat brain mitochondria. Arch Biochem Biophys. 2015 Dec 01; 587:70-7.
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Voltage-dependent anion channels modulate mitochondrial metabolism in cancer cells: regulation by free tubulin and erastin. J Biol Chem. 2013 Apr 26; 288(17):11920-9.