Ribosomal Protein S6 Kinases, 70-kDa
"Ribosomal Protein S6 Kinases, 70-kDa" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of ribosomal protein S6 kinases that are considered the major physiological kinases for RIBOSOMAL PROTEIN S6. Unlike RIBOSOMAL PROTEIN S6 KINASES, 90KDa the proteins in this family are sensitive to the inhibitory effects of RAPAMYCIN and contain a single kinase domain. They are referred to as 70kDa proteins, however ALTERNATIVE SPLICING of mRNAs for proteins in this class also results in 85kDa variants being formed.
| Descriptor ID |
D038762
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.862.249 D12.644.360.600.249 D12.776.476.600.249
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Ribosomal Protein S6 Kinases, 70-kDa".
Below are MeSH descriptors whose meaning is more specific than "Ribosomal Protein S6 Kinases, 70-kDa".
This graph shows the total number of publications written about "Ribosomal Protein S6 Kinases, 70-kDa" by people in this website by year, and whether "Ribosomal Protein S6 Kinases, 70-kDa" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 1 | 1 | 2 |
| 2014 | 0 | 2 | 2 |
| 2015 | 1 | 0 | 1 |
| 2018 | 2 | 0 | 2 |
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Below are the most recent publications written about "Ribosomal Protein S6 Kinases, 70-kDa" by people in Profiles.
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The p85 isoform of the kinase S6K1 functions as a secreted oncoprotein to facilitate cell migration and tumor growth. Sci Signal. 2018 03 27; 11(523).
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The mTOR-S6K pathway links growth signalling to DNA damage response by targeting RNF168. Nat Cell Biol. 2018 03; 20(3):320-331.
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The aromatic amino acid tryptophan stimulates skeletal muscle IGF1/p70s6k/mTor signaling in vivo and the expression of myogenic genes in vitro. Nutrition. 2015 Jul-Aug; 31(7-8):1018-24.
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Constitutive activation of CaMKKa signaling is sufficient but not necessary for mTORC1 activation and growth in mouse skeletal muscle. Am J Physiol Endocrinol Metab. 2014 Oct 15; 307(8):E686-94.
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Arrestin-dependent angiotensin AT1 receptor signaling regulates Akt and mTor-mediated protein synthesis. J Biol Chem. 2014 Sep 19; 289(38):26155-26166.
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Vascular tumors have increased p70 S6-kinase activation and are inhibited by topical rapamycin. Lab Invest. 2013 Oct; 93(10):1115-27.
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20-HETE and EETs in diabetic nephropathy: a novel mechanistic pathway. PLoS One. 2013; 8(8):e70029.
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Delayed phosphorylation of classical protein kinase C (PKC) substrates requires PKC internalization and formation of the pericentrion in a phospholipase D (PLD)-dependent manner. J Biol Chem. 2011 Jun 03; 286(22):19340-53.
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The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions. Cell Cycle. 2009 Dec 15; 8(24):4168-75.
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Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR. Biochem Pharmacol. 2008 May 15; 75(10):1981-93.