1-Methyl-3-isobutylxanthine
"1-Methyl-3-isobutylxanthine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
| Descriptor ID |
D015056
|
| MeSH Number(s) |
D03.633.100.759.758.824.751.500
|
| Concept/Terms |
1-Methyl-3-isobutylxanthine- 1-Methyl-3-isobutylxanthine
- 1 Methyl 3 isobutylxanthine
- IBMX
- Isobutyltheophylline
- 3-Isobutyl-1-methylxanthine
- 3 Isobutyl 1 methylxanthine
|
Below are MeSH descriptors whose meaning is more general than "1-Methyl-3-isobutylxanthine".
Below are MeSH descriptors whose meaning is more specific than "1-Methyl-3-isobutylxanthine".
This graph shows the total number of publications written about "1-Methyl-3-isobutylxanthine" by people in this website by year, and whether "1-Methyl-3-isobutylxanthine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 3 | 3 |
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2012 | 0 | 2 | 2 |
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Below are the most recent publications written about "1-Methyl-3-isobutylxanthine" by people in Profiles.
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Selective inhibition of phosphodiesterase 1 relaxes urinary bladder smooth muscle: role for ryanodine receptor-mediated BK channel activation. Am J Physiol Cell Physiol. 2012 Nov 15; 303(10):C1079-89.
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Constitutively active phosphodiesterase activity regulates urinary bladder smooth muscle function: critical role of KCa1.1 channel. Am J Physiol Renal Physiol. 2012 Nov 01; 303(9):F1300-6.
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Sustained elevation of intracellular cGMP causes oxidative stress triggering calpain-mediated apoptosis in photoreceptor degeneration. Curr Eye Res. 2007 Mar; 32(3):259-69.
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Turning cones off: the role of the 9-methyl group of retinal in red cones. J Gen Physiol. 2006 Dec; 128(6):671-85.
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Cellular localization and stimulation-associated distribution dynamics of syntaxin-1 and syntaxin-3 in gastric parietal cells. Traffic. 2005 Aug; 6(8):654-66.
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Intracellular distribution and functional importance of vesicle-associated membrane protein 2 in gastric parietal cells. Gastroenterology. 2002 Jul; 123(1):281-90.
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Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate. J Biol Chem. 2001 Sep 21; 276(38):35258-64.
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Functional identification of phosphodiesterase activity in human trabecular meshwork cells. J Ocul Pharmacol Ther. 2000 Aug; 16(4):317-22.
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Effect of 11-cis 13-demethylretinal on phototransduction in bleach-adapted rod and cone photoreceptors. J Gen Physiol. 2000 Aug; 116(2):283-97.
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Bleached pigment activates transduction in salamander cones. J Gen Physiol. 1995 Sep; 106(3):543-57.