"Lipoxygenase Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Compounds that bind to and inhibit that enzymatic activity of LIPOXYGENASES. Included under this category are inhibitors that are specific for lipoxygenase subtypes and act to reduce the production of LEUKOTRIENES.
| Descriptor ID |
D016859
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| MeSH Number(s) |
D27.505.519.389.480
|
| Concept/Terms |
Arachidonate 15-Lipoxygenase Inhibitors- Arachidonate 15-Lipoxygenase Inhibitors
- 15-Lipoxygenase Inhibitors, Arachidonate
- Arachidonate 15 Lipoxygenase Inhibitors
- Inhibitors, Arachidonate 15-Lipoxygenase
- 15-Lipoxygenase Inhibitors
- 15 Lipoxygenase Inhibitors
- Inhibitors, 15-Lipoxygenase
Arachidonate 5-Lipoxygenase Inhibitors- Arachidonate 5-Lipoxygenase Inhibitors
- 5-Lipoxygenase Inhibitors, Arachidonate
- Arachidonate 5 Lipoxygenase Inhibitors
- Inhibitors, Arachidonate 5-Lipoxygenase
- 5-Lipoxygenase Inhibitors
- 5 Lipoxygenase Inhibitors
- Inhibitors, 5-Lipoxygenase
Arachidonate 12-Lipoxygenase Inhibitors- Arachidonate 12-Lipoxygenase Inhibitors
- 12-Lipoxygenase Inhibitors, Arachidonate
- Arachidonate 12 Lipoxygenase Inhibitors
- Inhibitors, Arachidonate 12-Lipoxygenase
- 12-Lipoxygenase Inhibitors
- 12 Lipoxygenase Inhibitors
- Inhibitors, 12-Lipoxygenase
|
Below are MeSH descriptors whose meaning is more general than "Lipoxygenase Inhibitors".
Below are MeSH descriptors whose meaning is more specific than "Lipoxygenase Inhibitors".
This graph shows the total number of publications written about "Lipoxygenase Inhibitors" by people in this website by year, and whether "Lipoxygenase Inhibitors" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 2 | 0 | 2 |
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click here.
Below are the most recent publications written about "Lipoxygenase Inhibitors" by people in Profiles.
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Ghatak S, Vyas A, Misra S, O'Brien P, Zambre A, Fresco VM, Markwald RR, Swamy KV, Afrasiabi Z, Choudhury A, Khetmalas M, Padhye S. Novel di-tertiary-butyl phenylhydrazones as dual cyclooxygenase-2/5-lipoxygenase inhibitors: synthesis, COX/LOX inhibition, molecular modeling, and insights into their cytotoxicities. Bioorg Med Chem Lett. 2014 Jan 01; 24(1):317-24.
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Misra S, Ghatak S, Patil N, Dandawate P, Ambike V, Adsule S, Unni D, Venkateswara Swamy K, Padhye S. Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells. Bioorg Med Chem. 2013 May 01; 21(9):2551-9.
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Apraiz A, Idkowiak-Baldys J, Nieto-Rementería N, Boyano MD, Hannun YA, Asumendi A. Dihydroceramide accumulation and reactive oxygen species are distinct and nonessential events in 4-HPR-mediated leukemia cell death. Biochem Cell Biol. 2012 Apr; 90(2):209-23.
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Yoshinaga M, Buchanan FG, DuBois RN. 15-LOX-1 inhibits p21 (Cip/WAF 1) expression by enhancing MEK-ERK 1/2 signaling in colon carcinoma cells. Prostaglandins Other Lipid Mediat. 2004 Jan; 73(1-2):111-22.
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Tempel GE, Strong JW, Wise WC, Cook JA, Smith EF, Halushka PV. The role of eicosanoids in mediating blood flow alterations in endotoxin shock. Prog Clin Biol Res. 1989; 299:33-42.
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Matera G, Cook JA, Hennigar RA, Tempel GE, Wise WC, Oglesby TD, Halushka PV. Beneficial effects of a 5-lipoxygenase inhibitor in endotoxic shock in the rat. J Pharmacol Exp Ther. 1988 Oct; 247(1):363-71.