Amyloid Precursor Protein Secretases

"Amyloid Precursor Protein Secretases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Endopeptidases that are specific for AMYLOID PROTEIN PRECURSOR. Three secretase subtypes referred to as alpha, beta, and gamma have been identified based upon the region of amyloid protein precursor they cleave.

Descriptor ID	D053829
MeSH Number(s)	D08.811.277.656.300.032
Concept/Terms	Amyloid Precursor Protein Secretases Amyloid Precursor Protein Secretases Secretases Secretase Amyloid Precursor Protein Secretase APP Secretase Secretase, APP beta-Secretase beta-Secretase beta Secretase gamma-Secretase gamma-Secretase gamma Secretase alpha-Secretase alpha-Secretase alpha Secretase

Below are MeSH descriptors whose meaning is more general than "Amyloid Precursor Protein Secretases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Peptide Hydrolases [D08.811.277.656]
Endopeptidases [D08.811.277.656.300]
Amyloid Precursor Protein Secretases [D08.811.277.656.300.032]

Below are MeSH descriptors whose meaning is related to "Amyloid Precursor Protein Secretases".

Below are MeSH descriptors whose meaning is more specific than "Amyloid Precursor Protein Secretases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Amyloid Precursor Protein Secretases" by people in this website by year, and whether "Amyloid Precursor Protein Secretases" was a major or minor topic of these publications.

Bar chart showing 45 publications over 23 distinct years, with a maximum of 3 publications in 2001 and 2004 and 2006 and 2008 and 2010 and 2011 and 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	0	1	1
1995	0	1	1
1998	0	1	1
1999	0	1	1
2000	0	1	1
2001	0	3	3
2002	0	1	1
2003	0	2	2
2004	0	3	3
2006	1	2	3
2007	2	0	2
2008	2	1	3
2009	2	0	2
2010	0	3	3
2011	3	0	3
2012	1	1	2
2013	2	0	2
2014	1	1	2
2015	1	0	1
2016	1	0	1
2017	0	2	2
2020	2	1	3
2021	2	0	2

Below are the most recent publications written about "Amyloid Precursor Protein Secretases" by people in Profiles.

Cui J, Ait-Ghezala G, Sambamurti K, Gao F, Shen Y, Li R. Sex-Specific Regulation of ß-Secretase: A Novel Estrogen Response Element (ERE)-Dependent Mechanism in Alzheimer's Disease. J Neurosci. 2022 02 09; 42(6):1154-1165.

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Sajan MP, Leitges M, Park C, Diamond DM, Wu J, Hansen BC, Duncan MA, Apostolatos CA, Apostolatos AH, Kindy M, Farese RV. Control of ß-Site Amyloid Precursor Protein-Cleaving Enzyme-1 Expression by Protein Kinase C-?/? and Nuclear Factor ?-B. Curr Alzheimer Res. 2021; 18(12):941-955.

View in: PubMed
Wasson CW, Abignano G, Hermes H, Malaab M, Ross RL, Jimenez SA, Chang HY, Feghali-Bostwick CA, Del Galdo F. Long non-coding RNA HOTAIR drives EZH2-dependent myofibroblast activation in systemic sclerosis through miRNA 34a-dependent activation of NOTCH. Ann Rheum Dis. 2020 04; 79(4):507-517.

View in: PubMed
Ray B, Maloney B, Sambamurti K, Karnati HK, Nelson PT, Greig NH, Lahiri DK. Rivastigmine modifies the a-secretase pathway and potentially early Alzheimer's disease. Transl Psychiatry. 2020 02 03; 10(1):47.

View in: PubMed
Schrott L, Yi P, Jackson K, Jackson GS, Webb C, Minagar A, Yun JW, Purdum G, Rios DJ, Tyler TA, Vizcanio MI, Castor JL, Castor T, Alexander JS. Nanoparticle-Encapsulated Bryostatin-1 Activates a-Secretase and PKC Isoforms In vitro and Facilitates Acquisition and Retention of Spatial Learning in an Alzheimer's Disease Mouse Model. Curr Alzheimer Res. 2020; 17(14):1302-1310.

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Padi SKR, Luevano LA, An N, Pandey R, Singh N, Song JH, Aster JC, Yu XZ, Mehrotra S, Kraft AS. Targeting the PIM protein kinases for the treatment of a T-cell acute lymphoblastic leukemia subset. Oncotarget. 2017 May 02; 8(18):30199-30216.

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Ahuja M, Buabeid M, Abdel-Rahman E, Majrashi M, Parameshwaran K, Amin R, Ramesh S, Thiruchelvan K, Pondugula S, Suppiramaniam V, Dhanasekaran M. Immunological alteration & toxic molecular inductions leading to cognitive impairment & neurotoxicity in transgenic mouse model of Alzheimer's disease. Life Sci. 2017 May 15; 177:49-59.

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Rosenberg PB, Lanctôt KL, Herrmann N, Mintzer JE, Porsteinsson AP, Sun X, Raman R. Changes in Neuropsychiatric Inventory Associated with Semagacestat Treatment of Alzheimer's Disease. J Alzheimers Dis. 2016 08 10; 54(1):373-81.

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Baranello RJ, Bharani KL, Padmaraju V, Chopra N, Lahiri DK, Greig NH, Pappolla MA, Sambamurti K. Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease. Curr Alzheimer Res. 2015; 12(1):32-46.

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Barnwell E, Padmaraju V, Baranello R, Pacheco-Quinto J, Crosson C, Ablonczy Z, Eckman E, Eckman CB, Ramakrishnan V, Greig NH, Pappolla MA, Sambamurti K. Evidence of a novel mechanism for partial ?-secretase inhibition induced paradoxical increase in secreted amyloid ß protein. PLoS One. 2014; 9(3):e91531.

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