B-Cell Activating Factor

"B-Cell Activating Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A tumor necrosis factor superfamily member that plays a role in the regulation of B-LYMPHOCYTE survival. It occurs as a membrane-bound protein that is cleaved to release an biologically active soluble form with specificity to TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; B-CELL ACTIVATION FACTOR RECEPTOR; and B-CELL MATURATION ANTIGEN.

Descriptor ID	D053264
MeSH Number(s)	D12.644.276.374.750.061 D12.776.395.191 D12.776.467.374.750.061 D12.776.543.550.193 D23.529.374.750.061
Concept/Terms	B-Cell Activating Factor B-Cell Activating Factor Activating Factor, B-Cell B-Lymphocyte Activating Factor Activating Factor, B-Lymphocyte B Lymphocyte Activating Factor THANK Protein BAFF Ligand BLyS Protein B Cell Activating Factor B Lymphocyte Stimulator CD257 Antigen Antigen, CD257 Antigens, CD257 TNF and APOL-Related Leukocyte Expressed Ligand 1 TNF and APOL Related Leukocyte Expressed Ligand 1 TNF Superfamily, Member 13b Tumor Necrosis Factor Ligand Superfamily Member 13b CD257 Antigens TNFSF13B Protein TALL-1 Protein TALL 1 Protein

Below are MeSH descriptors whose meaning is more general than "B-Cell Activating Factor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Tumor Necrosis Factors [D12.644.276.374.750]
B-Cell Activating Factor [D12.644.276.374.750.061]
Proteins [D12.776]
Glycoproteins [D12.776.395]
B-Cell Activating Factor [D12.776.395.191]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Tumor Necrosis Factors [D12.776.467.374.750]
B-Cell Activating Factor [D12.776.467.374.750.061]
Membrane Proteins [D12.776.543]
Membrane Glycoproteins [D12.776.543.550]
B-Cell Activating Factor [D12.776.543.550.193]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Tumor Necrosis Factors [D23.529.374.750]
B-Cell Activating Factor [D23.529.374.750.061]

Below are MeSH descriptors whose meaning is related to "B-Cell Activating Factor".

Below are MeSH descriptors whose meaning is more specific than "B-Cell Activating Factor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "B-Cell Activating Factor" by people in this website by year, and whether "B-Cell Activating Factor" was a major or minor topic of these publications.

Bar chart showing 12 publications over 8 distinct years, with a maximum of 3 publications in 2008

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2008	2	1	3
2009	1	0	1
2010	1	1	2
2011	0	2	2
2012	0	1	1
2013	1	0	1
2015	0	1	1

Below are the most recent publications written about "B-Cell Activating Factor" by people in Profiles.

Asaba J, Bandyopadhyay M, Kindy M, Dasgupta S. Estrogen receptor signal in regulation of B cell activation during diverse immune responses. Int J Biochem Cell Biol. 2015 Nov; 68:42-7.

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Goenka R, Matthews AH, Zhang B, O'Neill PJ, Scholz JL, Migone TS, Leonard WJ, Stohl W, Hershberg U, Cancro MP. Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation. J Exp Med. 2014 Jan 13; 211(1):45-56.

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Ma X, Che N, Gu Z, Huang J, Wang D, Liang J, Hou Y, Gilkeson G, Lu L, Sun L. Allogenic mesenchymal stem cell transplantation ameliorates nephritis in lupus mice via inhibition of B-cell activation. Cell Transplant. 2013; 22(12):2279-90.

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Liu Z, Bethunaickan R, Huang W, Ramanujam M, Madaio MP, Davidson A. IFN-a confers resistance of systemic lupus erythematosus nephritis to therapy in NZB/W F1 mice. J Immunol. 2011 Aug 01; 187(3):1506-13.

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Hao Y, O'Neill P, Naradikian MS, Scholz JL, Cancro MP. A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice. Blood. 2011 Aug 04; 118(5):1294-304.

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Ramanujam M, Bethunaickan R, Huang W, Tao H, Madaio MP, Davidson A. Selective blockade of BAFF for the prevention and treatment of systemic lupus erythematosus nephritis in NZM2410 mice. Arthritis Rheum. 2010 May; 62(5):1457-68.

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Begum-Haque S, Sharma A, Christy M, Lentini T, Ochoa-Reparaz J, Fayed IF, Mielcarz D, Haque A, Kasper LH. Increased expression of B cell-associated regulatory cytokines by glatiramer acetate in mice with experimental autoimmune encephalomyelitis. J Neuroimmunol. 2010 Feb 26; 219(1-2):47-53.

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Walters S, Webster KE, Sutherland A, Gardam S, Groom J, Liuwantara D, Mariño E, Thaxton J, Weinberg A, Mackay F, Brink R, Sprent J, Grey ST. Increased CD4+Foxp3+ T cells in BAFF-transgenic mice suppress T cell effector responses. J Immunol. 2009 Jan 15; 182(2):793-801.

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Scholz JL, Crowley JE, Tomayko MM, Steinel N, O'Neill PJ, Quinn WJ, Goenka R, Miller JP, Cho YH, Long V, Ward C, Migone TS, Shlomchik MJ, Cancro MP. BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15517-22.

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Kahn P, Ramanujam M, Bethunaickan R, Huang W, Tao H, Madaio MP, Factor SM, Davidson A. Prevention of murine antiphospholipid syndrome by BAFF blockade. Arthritis Rheum. 2008 Sep; 58(9):2824-34.

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