Proto-Oncogene Proteins p21(ras)

"Proto-Oncogene Proteins p21(ras)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Cellular proteins encoded by the H-ras, K-ras and N-ras genes. The proteins have GTPase activity and are involved in signal transduction as monomeric GTP-binding proteins. Elevated levels of p21 c-ras have been associated with neoplasia. This enzyme was formerly listed as EC 3.6.1.47.

Descriptor ID	D016283
MeSH Number(s)	D08.811.277.040.330.300.400.500.600 D12.644.360.525.500.600 D12.776.157.325.515.500.600 D12.776.476.525.500.600 D12.776.624.664.700.200
Concept/Terms	Proto-Oncogene Proteins p21(ras) Proto-Oncogene Proteins p21(ras) p21 c-ras c-ras, p21 p21 c ras p21(c-ras) ras Proto-Oncogene Protein p21 ras Proto Oncogene Protein p21 Proto-Oncogene Proteins c-ras Proteins c-ras, Proto-Oncogene Proto Oncogene Proteins c ras c-ras, Proto-Oncogene Proteins Proto-Oncogene Protein ras Proto Oncogene Protein ras ras, Proto-Oncogene Protein ras Proto-Oncogene Product p21 ras Proto Oncogene Product p21 c-ras Proteins c ras Proteins p21(ras) Proto-Oncogene Protein p21(ras) Proto-Oncogene Protein p21(c-N-ras) Proto-Oncogene Protein p21(c-N-ras) p21(N-ras) Proto-Oncogene Protein p21(c-Ha-ras) Proto-Oncogene Protein p21(c-Ha-ras) p21 c-Ha-ras c-Ha-ras, p21 p21 c Ha ras p21(c-Ha-ras) p21 c-H-ras c-H-ras, p21 p21 c H ras c-Ha-ras p21 c Ha ras p21 p21, c-Ha-ras Proto-Oncogene Protein p21(c-Ki-ras) Proto-Oncogene Protein p21(c-Ki-ras) p21 c-Ki-ras c-Ki-ras, p21 p21 c Ki ras p21(c-Ki-ras) p21 c-K-ras c-K-ras, p21 p21 c K ras c-Ki-ras p21 c Ki ras p21 p21, c-Ki-ras

Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins p21(ras)".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Acid Anhydride Hydrolases [D08.811.277.040]
GTP Phosphohydrolases [D08.811.277.040.330]
GTP-Binding Proteins [D08.811.277.040.330.300]
Monomeric GTP-Binding Proteins [D08.811.277.040.330.300.400]
ras Proteins [D08.811.277.040.330.300.400.500]
Proto-Oncogene Proteins p21(ras) [D08.811.277.040.330.300.400.500.600]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Monomeric GTP-Binding Proteins [D12.644.360.525]
ras Proteins [D12.644.360.525.500]
Proto-Oncogene Proteins p21(ras) [D12.644.360.525.500.600]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
GTP-Binding Proteins [D12.776.157.325]
Monomeric GTP-Binding Proteins [D12.776.157.325.515]
ras Proteins [D12.776.157.325.515.500]
Proto-Oncogene Proteins p21(ras) [D12.776.157.325.515.500.600]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Monomeric GTP-Binding Proteins [D12.776.476.525]
ras Proteins [D12.776.476.525.500]
Proto-Oncogene Proteins p21(ras) [D12.776.476.525.500.600]
Neoplasm Proteins [D12.776.624]
Oncogene Proteins [D12.776.624.664]
Proto-Oncogene Proteins [D12.776.624.664.700]
Proto-Oncogene Proteins p21(ras) [D12.776.624.664.700.200]

Below are MeSH descriptors whose meaning is related to "Proto-Oncogene Proteins p21(ras)".

Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins p21(ras)".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Proto-Oncogene Proteins p21(ras)" by people in this website by year, and whether "Proto-Oncogene Proteins p21(ras)" was a major or minor topic of these publications.

Bar chart showing 44 publications over 22 distinct years, with a maximum of 8 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	1	0	1
1994	1	1	2
1995	0	1	1
1996	1	0	1
1997	1	0	1
1998	1	0	1
1999	1	0	1
2001	0	2	2
2002	0	1	1
2003	0	1	1
2005	1	0	1
2011	0	1	1
2012	4	4	8
2013	1	3	4
2014	1	2	3
2015	0	2	2
2016	1	1	2
2017	3	1	4
2019	1	1	2
2020	1	1	2
2021	1	1	2
2022	0	1	1

Below are the most recent publications written about "Proto-Oncogene Proteins p21(ras)" by people in Profiles.

Wu J, Liu X, Reeser JAW, Trimboli AJ, Pécot T, Sizemore GM, Naidu SK, Fernandez SA, Yu L, Hallett M, Park M, Leone GW, Hildreth BE, Ostrowski MC. Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner. Mol Cancer Res. 2022 08 05; 20(8):1233-1246.

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Sadeghi MM, Salama MF, Hannun YA. Protein Kinase C as a Therapeutic Target in Non-Small Cell Lung Cancer. Int J Mol Sci. 2021 May 24; 22(11).

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Teng KW, Tsai ST, Hattori T, Fedele C, Koide A, Yang C, Hou X, Zhang Y, Neel BG, O'Bryan JP, Koide S. Selective and noncovalent targeting of RAS mutants for inhibition and degradation. Nat Commun. 2021 05 11; 12(1):2656.

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Zuberi M, Khan I, O'Bryan JP. Inhibition of RAS: proven and potential vulnerabilities. Biochem Soc Trans. 2020 10 30; 48(5):1831-1841.

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Janakiraman H, Zhu Y, Becker SA, Wang C, Cross A, Curl E, Lewin D, Hoffman BJ, Warren GW, Hill EG, Timmers C, Findlay VJ, Camp ER. Modeling rectal cancer to advance neoadjuvant precision therapy. Int J Cancer. 2020 09 01; 147(5):1405-1418.

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Sun F, Li L, Yan P, Zhou J, Shapiro SD, Xiao G, Qu Z. Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance. Nat Commun. 2019 11 22; 10(1):5324.

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Owen DH, Konda B, Sipos J, Liu T, Webb A, Ringel MD, Timmers CD, Shah MH. KRAS G12V Mutation in Acquired Resistance to Combined BRAF and MEK Inhibition in Papillary Thyroid Cancer. J Natl Compr Canc Netw. 2019 05 01; 17(5):409-413.

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Yamada T, Amann JM, Tanimoto A, Taniguchi H, Shukuya T, Timmers C, Yano S, Shilo K, Carbone DP. Histone Deacetylase Inhibition Enhances the Antitumor Activity of a MEK Inhibitor in Lung Cancer Cells Harboring RAS Mutations. Mol Cancer Ther. 2018 01; 17(1):17-25.

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Wu J, Liu X, Nayak SG, Pitarresi JR, Cuitiño MC, Yu L, Hildreth BE, Thies KA, Schilling DJ, Fernandez SA, Leone G, Ostrowski MC. Generation of a pancreatic cancer model using a Pdx1-Flp recombinase knock-in allele. PLoS One. 2017; 12(9):e0184984.

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Om A, Cathey SS, Gathings RM, Hudspeth M, Lee JA, Marzolf S, Wine Lee L. Phacomatosis Pigmentokeratotica: A Mosaic RASopathy with Malignant Potential. Pediatr Dermatol. 2017 May; 34(3):352-355.

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