Proto-Oncogene Proteins c-cbl
                             
                            
                            
                                
                                    
                                            
	"Proto-Oncogene Proteins c-cbl" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, 
	MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, 
	which enables searching at various levels of specificity.
	
	
		
			
			
				Proto-oncogene proteins that negatively regulate RECEPTOR PROTEIN-TYROSINE KINASE signaling. It is a UBIQUITIN-PROTEIN LIGASE and the cellular homologue of ONCOGENE PROTEIN V-CBL.
    
			
			
				
				
					
						| Descriptor ID | D050721 | 
					
						| MeSH Number(s) | D08.811.464.938.750.374 D12.776.624.664.700.172 | 
					
						| Concept/Terms | Proto-Oncogene Proteins c-cblProto-Oncogene Proteins c-cblProto Oncogene Proteins c cblc-cbl, Proto-Oncogene ProteinsRING Finger Protein 55c-cbl Proteincbl Proto-Oncogene ProteinProto-Oncogene Protein, cblcbl Proto Oncogene ProteinCBL E3 Ubiquitin Protein Ligasec-cbl Proto-Oncogene ProteinProto-Oncogene Protein, c-cblc cbl Proto Oncogene ProteinRNF55 ProteinProto-Oncogene Protein c-cblProto Oncogene Protein c cblc-cbl, Proto-Oncogene Protein
 | 
					
				
			 
			
				Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-cbl".
				
			 
			
			
				Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-cbl".
				
			 
		 
	 
 
                                        
                                            
	
	
		
			
			
					
				This graph shows the total number of publications written about "Proto-Oncogene Proteins c-cbl" by people in this website by year, and whether "Proto-Oncogene Proteins c-cbl" was a major or minor topic of these publications. 
				
					 
                    To see the data from this visualization as text, 
click here. 
                
		            | Year | Major Topic | Minor Topic | Total | 
|---|
| 2006 | 0 | 1 | 1 | 
| 2009 | 1 | 0 | 1 | 
| 2011 | 1 | 0 | 1 | 
| 2013 | 1 | 0 | 1 | 
| 2017 | 0 | 1 | 1 | 
                    To return to the timeline, 
click here.
                 
			 	
			
			
			
			
				Below are the most recent publications written about "Proto-Oncogene Proteins c-cbl" by people in Profiles.
						
					
								- 
								The ShcD phosphotyrosine adaptor subverts canonical EGF receptor trafficking. J Cell Sci. 2017 Sep 01; 130(17):2808-2820. 
- 
								Receptor tyrosine kinase ubiquitylation involves the dynamic regulation of Cbl-Spry2 by intersectin 1 and the Shp2 tyrosine phosphatase. Mol Cell Biol. 2014 Jan; 34(2):271-9. 
- 
								Intersectin 1 enhances Cbl ubiquitylation of epidermal growth factor receptor through regulation of Sprouty2-Cbl interaction. Mol Cell Biol. 2012 Feb; 32(4):817-25. 
- 
								Essential role of c-Cbl in amphiregulin-induced recycling and signaling of the endogenous epidermal growth factor receptor. Biochemistry. 2009 Feb 24; 48(7):1462-73. 
- 
								Intersectin regulates epidermal growth factor receptor endocytosis, ubiquitylation, and signaling. Mol Pharmacol. 2006 Nov; 70(5):1643-53.