Urokinase-Type Plasminogen Activator
"Urokinase-Type Plasminogen Activator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A proteolytic enzyme that converts PLASMINOGEN to FIBRINOLYSIN where the preferential cleavage is between ARGININE and VALINE. It was isolated originally from human URINE, but is found in most tissues of most VERTEBRATES.
| Descriptor ID |
D014568
|
| MeSH Number(s) |
D08.811.277.656.300.760.910 D08.811.277.656.959.350.910 D12.776.124.125.662.884
|
| Concept/Terms |
Urokinase-Type Plasminogen Activator- Urokinase-Type Plasminogen Activator
- Urokinase Type Plasminogen Activator
- Plasminogen Activator, Urokinase-Type
- U-Plasminogen Activator
- U Plasminogen Activator
- U-PA
- Urinary Plasminogen Activator
- Urokinase
|
Below are MeSH descriptors whose meaning is more general than "Urokinase-Type Plasminogen Activator".
Below are MeSH descriptors whose meaning is more specific than "Urokinase-Type Plasminogen Activator".
This graph shows the total number of publications written about "Urokinase-Type Plasminogen Activator" by people in this website by year, and whether "Urokinase-Type Plasminogen Activator" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 2 | 3 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2003 | 1 | 1 | 2 |
| 2004 | 1 | 0 | 1 |
| 2009 | 0 | 2 | 2 |
| 2013 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Urokinase-Type Plasminogen Activator" by people in Profiles.
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E4 engages uPAR and enolase-1 and activates urokinase to exert antifibrotic effects. JCI Insight. 2021 12 22; 6(24).
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Rapid detection of urokinase plasminogen activator using flexible paper-based graphene-gold platform. Biointerphases. 2020 02 04; 15(1):011004.
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Cytokine and estrogen stimulation of endothelial cells augments activation of the prekallikrein-high molecular weight kininogen complex: Implications for hereditary angioedema. J Allergy Clin Immunol. 2017 Jul; 140(1):170-176.
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Theranostic nanoparticles with controlled release of gemcitabine for targeted therapy and MRI of pancreatic cancer. ACS Nano. 2013 Mar 26; 7(3):2078-89.
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PDEF is a negative regulator of colon cancer cell growth and migration. J Cell Biochem. 2009 Dec 15; 108(6):1389-98.
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Knockout of plasminogen activator inhibitor 1 gene reduces amyloid beta peptide burden in a mouse model of Alzheimer's disease. Neurobiol Aging. 2011 Jun; 32(6):1079-89.
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Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene. Hum Mol Genet. 2005 Feb 01; 14(3):447-60.
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Intestinal transformation results in transforming growth factor-beta-dependent alteration in tumor cell-cell matrix interactions. Surgery. 2003 May; 133(5):568-79.
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Intrapleural instillation of fibrinolytic agents for treatment of pleural empyema. Pediatr Crit Care Med. 2003 Jan; 4(1):39-43.
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Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus. Hepatology. 2001 Apr; 33(4):981-8.