Below are the most recent publications written about "Aspartic Acid Endopeptidases" by people in Profiles.
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Sajan MP, Leitges M, Park C, Diamond DM, Wu J, Hansen BC, Duncan MA, Apostolatos CA, Apostolatos AH, Kindy M, Farese RV. Control of ß-Site Amyloid Precursor Protein-Cleaving Enzyme-1 Expression by Protein Kinase C-?/? and Nuclear Factor ?-B. Curr Alzheimer Res. 2021; 18(12):941-955.
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Ray B, Maloney B, Sambamurti K, Karnati HK, Nelson PT, Greig NH, Lahiri DK. Rivastigmine modifies the a-secretase pathway and potentially early Alzheimer's disease. Transl Psychiatry. 2020 02 03; 10(1):47.
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Barnwell E, Padmaraju V, Baranello R, Pacheco-Quinto J, Crosson C, Ablonczy Z, Eckman E, Eckman CB, Ramakrishnan V, Greig NH, Pappolla MA, Sambamurti K. Evidence of a novel mechanism for partial ?-secretase inhibition induced paradoxical increase in secreted amyloid ß protein. PLoS One. 2014; 9(3):e91531.
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Hook G, Yu J, Toneff T, Kindy M, Hook V. Brain pyroglutamate amyloid-ß is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeutic. J Alzheimers Dis. 2014; 41(1):129-49.
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Wang R, Li JJ, Diao S, Kwak YD, Liu L, Zhi L, Büeler H, Bhat NR, Williams RW, Park EA, Liao FF. Metabolic stress modulates Alzheimer's ß-secretase gene transcription via SIRT1-PPAR?-PGC-1 in neurons. Cell Metab. 2013 May 07; 17(5):685-94.
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Ding Y, Ko MH, Pehar M, Kotch F, Peters NR, Luo Y, Salamat SM, Puglielli L. Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces ß-secretase (BACE1) levels and Aß generation. J Biol Chem. 2012 Mar 09; 287(11):8424-33.
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Kindy MS, Yu J, Zhu H, El-Amouri SS, Hook V, Hook GR. Deletion of the cathepsin B gene improves memory deficits in a transgenic ALZHeimer's disease mouse model expressing AßPP containing the wild-type ß-secretase site sequence. J Alzheimers Dis. 2012; 29(4):827-40.
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Hook G, Hook V, Kindy M. The cysteine protease inhibitor, E64d, reduces brain amyloid-ß and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, ß-secretase activity. J Alzheimers Dis. 2011; 26(2):387-408.
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Jonas MC, Pehar M, Puglielli L. AT-1 is the ER membrane acetyl-CoA transporter and is essential for cell viability. J Cell Sci. 2010 Oct 01; 123(Pt 19):3378-88.
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Whyteside AR, Hinsley EE, Lambert LA, McDermott PJ, Turner AJ. ECE-1 influences prostate cancer cell invasion via ET-1-mediated FAK phosphorylation and ET-1-independent mechanisms. Can J Physiol Pharmacol. 2010 Aug; 88(8):850-4.