Heterocyclic Compounds, 4 or More Rings

"Heterocyclic Compounds, 4 or More Rings" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

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A class of heterocyclic compounds that include four or more fused rings. Both aromatic or non-aromatic ring structures are included in this category.

Descriptor ID	D006576
MeSH Number(s)	D03.633.400
Concept/Terms	Heterocyclic Compounds, 4 or More Rings Heterocyclic Compounds, 4 or More Rings Heterocyclic Compounds with 4 or More Rings Heterocyclic Cpds, 4 or More Rings Heterocyclic Compounds with Four or More Rings Heterocyclic Compounds, 5-Ring Heterocyclic Compounds, 5-Ring 5-Ring Heterocyclic Compounds Heterocyclic Compounds, 5 Ring Heterocyclic Cpds, 5 Ring Five Ring Heterocyclic Compounds Fused Heterocyclic Compounds, Five-Ring Fused Heterocyclic Compounds, Five Ring Heterocyclic Compounds, 4-Ring Heterocyclic Compounds, 4-Ring 4-Ring Heterocyclic Compounds Heterocyclic Compounds, 4 Ring Heterocyclic Cpds, 4 Ring Four Ring Heterocyclic Compounds Fused Heterocyclic Compounds, Four-Ring Fused Heterocyclic Compounds, Four Ring

Below are MeSH descriptors whose meaning is more general than "Heterocyclic Compounds, 4 or More Rings".

Chemicals and Drugs [D]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, Fused-Ring [D03.633]
Heterocyclic Compounds, 4 or More Rings [D03.633.400]

Below are MeSH descriptors whose meaning is related to "Heterocyclic Compounds, 4 or More Rings".

Below are MeSH descriptors whose meaning is more specific than "Heterocyclic Compounds, 4 or More Rings".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Heterocyclic Compounds, 4 or More Rings" by people in this website by year, and whether "Heterocyclic Compounds, 4 or More Rings" was a major or minor topic of these publications.

Bar chart showing 24 publications over 11 distinct years, with a maximum of 5 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2010	1	0	1
2011	2	0	2
2012	1	0	1
2013	3	0	3
2014	5	0	5
2015	3	0	3
2016	0	1	1
2017	0	1	1
2018	3	0	3
2019	1	2	3
2020	0	1	1

Below are the most recent publications written about "Heterocyclic Compounds, 4 or More Rings" by people in Profiles.

Dwyer CJ, Arhontoulis DC, Rangel Rivera GO, Knochelmann HM, Smith AS, Wyatt MM, Rubinstein MP, Atkinson C, Thaxton JE, Neskey DM, Paulos CM. Ex vivo blockade of PI3K gamma or delta signaling enhances the antitumor potency of adoptively transferred CD8+ T cells. Eur J Immunol. 2020 09; 50(9):1386-1399.

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Stellbrink HJ, Arribas JR, Stephens JL, Albrecht H, Sax PE, Maggiolo F, Creticos C, Martorell CT, Wei X, Acosta R, Collins SE, Brainard D, Martin H. Co-formulated bictegravir, emtricitabine, and tenofovir alafenamide versus dolutegravir with emtricitabine and tenofovir alafenamide for initial treatment of HIV-1 infection: week 96 results from a randomised, double-blind, multicentre, phase 3, non-inferiority trial. Lancet HIV. 2019 06; 6(6):e364-e372.

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Graves PR, Aponte-Collazo LJ, Fennell EMJ, Graves AC, Hale AE, Dicheva N, Herring LE, Gilbert TSK, East MP, McDonald IM, Lockett MR, Ashamalla H, Moorman NJ, Karanewsky DS, Iwanowicz EJ, Holmuhamedov E, Graves LM. Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues. ACS Chem Biol. 2019 05 17; 14(5):1020-1029.

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Ward R, Li W, Abdul Y, Jackson L, Dong G, Jamil S, Filosa J, Fagan SC, Ergul A. NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia. Pharmacol Res. 2019 04; 142:237-250.

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Sharara AI, Rustom LBO, Marrache M, Rimmani HH, Bou Daher H, Koussa S, Taher A. Sofosbuvir/velpatasvir for chronic hepatitis C infection in patients with transfusion-dependent thalassemia. Am J Hematol. 2019 02; 94(2):E43-E45.

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Dattaroy D, Seth RK, Sarkar S, Kimono D, Albadrani M, Chandrashekaran V, Hasson FA, Singh UP, Fan D, Nagarkatti M, Nagarkatti P, Diehl AM, Chatterjee S. Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent. Eur J Pharmacol. 2018 Dec 15; 841:33-48.

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Hayes-Jordan AA, Ma X, Menegaz BA, Lamhamedi-Cherradi SE, Kingsley CV, Benson JA, Camacho PE, Ludwig JA, Lockworth CR, Garcia GE, Craig SL. Efficacy of ONC201 in Desmoplastic Small Round Cell Tumor. Neoplasia. 2018 05; 20(5):524-532.

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Gupta P, Martin R, Knölker HJ, Nihalani D, Kumar Sinha D. Myosin-1 inhibition by PClP affects membrane shape, cortical actin distribution and lipid droplet dynamics in early Zebrafish embryos. PLoS One. 2017; 12(7):e0180301.

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Liu H, Qin W, Wang Z, Shao Y, Wang J, Borg TK, Gao BZ, Xu M. Disassembly of myofibrils and potential imbalanced forces on Z-discs in cultured adult cardiomyocytes. Cytoskeleton (Hoboken). 2016 May; 73(5):246-57.

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Dattaroy D, Seth RK, Das S, Alhasson F, Chandrashekaran V, Michelotti G, Fan D, Nagarkatti M, Nagarkatti P, Diehl AM, Chatterjee S. Sparstolonin B attenuates early liver inflammation in experimental NASH by modulating TLR4 trafficking in lipid rafts via NADPH oxidase activation. Am J Physiol Gastrointest Liver Physiol. 2016 04 01; 310(7):G510-25.

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