"Amphiregulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An autocrine growth factor and mitogen for a broad range of target cells including EPITHELIAL CELLS; FIBROBLASTS and immune cells. It occurs as a membrane-bound protein that can be cleaved to release an active secreted form.
Descriptor ID |
D066258
|
MeSH Number(s) |
D12.644.276.382.249 D12.776.467.382.249 D12.776.543.029 D23.529.382.249
|
Concept/Terms |
Amphiregulin- Amphiregulin
- Schwannoma-derived Growth Factor
- Schwannoma derived Growth Factor
|
Below are MeSH descriptors whose meaning is more general than "Amphiregulin".
Below are MeSH descriptors whose meaning is more specific than "Amphiregulin".
This graph shows the total number of publications written about "Amphiregulin" by people in this website by year, and whether "Amphiregulin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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2006 | 0 | 1 | 1 |
2007 | 0 | 1 | 1 |
2008 | 0 | 2 | 2 |
2009 | 0 | 2 | 2 |
2010 | 0 | 1 | 1 |
2011 | 0 | 1 | 1 |
2012 | 0 | 1 | 1 |
2014 | 0 | 1 | 1 |
2017 | 1 | 0 | 1 |
2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Amphiregulin" by people in Profiles.
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Cumulus cell pappalysin-1, luteinizing hormone/choriogonadotropin receptor, amphiregulin and hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 mRNA levels associate with oocyte developmental competence and embryo outcomes. J Assist Reprod Genet. 2019 Jul; 36(7):1457-1469.
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Amphiregulin regulates proliferation and migration of HER2-positive breast cancer cells. Cell Oncol (Dordr). 2018 Apr; 41(2):159-168.
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Oncogenic signaling in amphiregulin and EGFR-expressing PTEN-null human breast cancer. Mol Oncol. 2015 Feb; 9(2):527-43.
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Amphiregulin stimulates liver regeneration after small-for-size mouse liver transplantation. Am J Transplant. 2012 Aug; 12(8):2052-61.
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Knock-down of amphiregulin inhibits cellular invasion in inflammatory breast cancer. J Cell Physiol. 2011 Oct; 226(10):2691-701.
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Plasma kallikrein promotes epidermal growth factor receptor transactivation and signaling in vascular smooth muscle through direct activation of protease-activated receptors. J Biol Chem. 2010 Nov 05; 285(45):35206-15.
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Amphiregulin mediates self-renewal in an immortal mammary epithelial cell line with stem cell characteristics. Exp Cell Res. 2010 Feb 01; 316(3):422-32.
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Essential role of c-Cbl in amphiregulin-induced recycling and signaling of the endogenous epidermal growth factor receptor. Biochemistry. 2009 Feb 24; 48(7):1462-73.
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Altered EGFR localization and degradation in human breast cancer cells with an amphiregulin/EGFR autocrine loop. Cell Signal. 2009 Feb; 21(2):212-9.
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Amphiregulin as a novel target for breast cancer therapy. J Mammary Gland Biol Neoplasia. 2008 Jun; 13(2):171-9.