Amphiregulin

"Amphiregulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An autocrine growth factor and mitogen for a broad range of target cells including EPITHELIAL CELLS; FIBROBLASTS and immune cells. It occurs as a membrane-bound protein that can be cleaved to release an active secreted form.

Descriptor ID	D066258
MeSH Number(s)	D12.644.276.382.249 D12.776.467.382.249 D12.776.543.029 D23.529.382.249
Concept/Terms	Amphiregulin Amphiregulin Schwannoma-derived Growth Factor Schwannoma derived Growth Factor

Below are MeSH descriptors whose meaning is more general than "Amphiregulin".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
EGF Family of Proteins [D12.644.276.382]
Amphiregulin [D12.644.276.382.249]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
EGF Family of Proteins [D12.776.467.382]
Amphiregulin [D12.776.467.382.249]
Membrane Proteins [D12.776.543]
Amphiregulin [D12.776.543.029]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
EGF Family of Proteins [D23.529.382]
Amphiregulin [D23.529.382.249]

Below are MeSH descriptors whose meaning is related to "Amphiregulin".

Below are MeSH descriptors whose meaning is more specific than "Amphiregulin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Amphiregulin" by people in this website by year, and whether "Amphiregulin" was a major or minor topic of these publications.

Bar chart showing 13 publications over 11 distinct years, with a maximum of 2 publications in 2008 and 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2006	0	1	1
2007	0	1	1
2008	0	2	2
2009	0	2	2
2010	0	1	1
2011	0	1	1
2012	0	1	1
2014	0	1	1
2017	1	0	1
2019	1	0	1

Below are the most recent publications written about "Amphiregulin" by people in Profiles.

Kordus RJ, Hossain A, Corso MC, Chakraborty H, Whitman-Elia GF, LaVoie HA. Cumulus cell pappalysin-1, luteinizing hormone/choriogonadotropin receptor, amphiregulin and hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 mRNA levels associate with oocyte developmental competence and embryo outcomes. J Assist Reprod Genet. 2019 Jul; 36(7):1457-1469.

View in: PubMed
Schmucker H, Blanding WM, Mook JM, Wade JF, Park JP, Kwist K, Shah H, Booth BW. Amphiregulin regulates proliferation and migration of HER2-positive breast cancer cells. Cell Oncol (Dordr). 2018 Apr; 41(2):159-168.

View in: PubMed
Kappler CS, Guest ST, Irish JC, Garrett-Mayer E, Kratche Z, Wilson RC, Ethier SP. Oncogenic signaling in amphiregulin and EGFR-expressing PTEN-null human breast cancer. Mol Oncol. 2015 Feb; 9(2):527-43.

View in: PubMed
Liu Q, Rehman H, Krishnasamy Y, Haque K, Schnellmann RG, Lemasters JJ, Zhong Z. Amphiregulin stimulates liver regeneration after small-for-size mouse liver transplantation. Am J Transplant. 2012 Aug; 12(8):2052-61.

View in: PubMed
Baillo A, Giroux C, Ethier SP. Knock-down of amphiregulin inhibits cellular invasion in inflammatory breast cancer. J Cell Physiol. 2011 Oct; 226(10):2691-701.

View in: PubMed
Abdallah RT, Keum JS, El-Shewy HM, Lee MH, Wang B, Gooz M, Luttrell DK, Luttrell LM, Jaffa AA. Plasma kallikrein promotes epidermal growth factor receptor transactivation and signaling in vascular smooth muscle through direct activation of protease-activated receptors. J Biol Chem. 2010 Nov 05; 285(45):35206-15.

View in: PubMed
Booth BW, Boulanger CA, Anderson LH, Jimenez-Rojo L, Brisken C, Smith GH. Amphiregulin mediates self-renewal in an immortal mammary epithelial cell line with stem cell characteristics. Exp Cell Res. 2010 Feb 01; 316(3):422-32.

View in: PubMed
Baldys A, Göoz M, Morinelli TA, Lee MH, Raymond JR, Luttrell LM, Raymond JR. Essential role of c-Cbl in amphiregulin-induced recycling and signaling of the endogenous epidermal growth factor receptor. Biochemistry. 2009 Feb 24; 48(7):1462-73.

View in: PubMed
Willmarth NE, Baillo A, Dziubinski ML, Wilson K, Riese DJ, Ethier SP. Altered EGFR localization and degradation in human breast cancer cells with an amphiregulin/EGFR autocrine loop. Cell Signal. 2009 Feb; 21(2):212-9.

View in: PubMed
Willmarth NE, Ethier SP. Amphiregulin as a novel target for breast cancer therapy. J Mammary Gland Biol Neoplasia. 2008 Jun; 13(2):171-9.

View in: PubMed

People

Explore

Similar Concepts

Top Journals