Disks Large Homolog 4 Protein
"Disks Large Homolog 4 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A neuronal protein consisting of three PDZ DOMAINS, an SH3 DOMAIN, and a C-terminal guanylate kinase-like region (see MAGUK PROTEINS). It localizes to the POST-SYNAPTIC DENSITY and associates with the cytoplasmic tail of NMDA RECEPTORS and SHAKER POTASSIUM CHANNELS, playing a critical role in NMDA receptor-mediated SYNAPTIC PLASTICITY.
| Descriptor ID |
D000076122
|
| MeSH Number(s) |
D08.811.913.696.650.450.750 D12.644.360.265 D12.776.476.265 D12.776.543.219 D12.776.631.224
|
| Concept/Terms |
Disks Large Homolog 4 Protein- Disks Large Homolog 4 Protein
- Postsynaptic Density Protein 95
- Discs Large Homolog 4 Protein
- SAP-90 Protein
- SAP 90 Protein
- PSD95 Protein
- PSD-95 Protein
- PSD 95 Protein
- Synapse-Associated Protein 90
- Synapse Associated Protein 90
- SAP90 Protein
|
Below are MeSH descriptors whose meaning is more general than "Disks Large Homolog 4 Protein".
Below are MeSH descriptors whose meaning is more specific than "Disks Large Homolog 4 Protein".
This graph shows the total number of publications written about "Disks Large Homolog 4 Protein" by people in this website by year, and whether "Disks Large Homolog 4 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 2 | 2 |
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 2 | 2 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2018 | 1 | 1 | 2 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Disks Large Homolog 4 Protein" by people in Profiles.
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Fuzzy supertertiary interactions within PSD-95 enable ligand binding. Elife. 2022 09 07; 11.
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Identifying weak interdomain interactions that stabilize the supertertiary structure of the N-terminal tandem PDZ domains of PSD-95. Nat Commun. 2018 09 13; 9(1):3724.
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Chemogenetic Manipulation of Dorsal Hippocampal Astrocytes Protects Against the Development of Stress-enhanced Fear Learning. Neuroscience. 2018 09 15; 388:45-56.
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Tau-mediated NMDA receptor impairment underlies dysfunction of a selectively vulnerable network in a mouse model of frontotemporal dementia. J Neurosci. 2014 Dec 03; 34(49):16482-95.
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Glycogen synthase kinase-3 inhibitors reverse deficits in long-term potentiation and cognition in fragile X mice. Biol Psychiatry. 2014 Feb 01; 75(3):198-206.
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Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95. Cell. 2012 Dec 21; 151(7):1581-94.
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Chronic ethanol up-regulates the synaptic expression of the nuclear translational regulatory protein AIDA-1 in primary hippocampal neurons. Alcohol. 2012 Sep; 46(6):569-76.
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Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seeking. J Neurosci. 2010 Jun 09; 30(23):7984-92.
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Glutamate transporters regulate extrasynaptic NMDA receptor modulation of Kv2.1 potassium channels. J Neurosci. 2008 Aug 27; 28(35):8801-9.
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Apolipoprotein E receptor 2 interactions with the N-methyl-D-aspartate receptor. J Biol Chem. 2006 Feb 10; 281(6):3425-31.