Receptor, IGF Type 1

"Receptor, IGF Type 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The beta subunit contains an intrinsic tyrosine kinase domain.

Descriptor ID	D017526
MeSH Number(s)	D08.811.913.696.620.682.725.400.185 D12.776.543.750.630.468 D12.776.543.750.750.400.780.400
Concept/Terms	Receptor, IGF Type 1 Receptor, IGF Type 1 Receptors, IGF-1 IGF-1 Receptors Receptors, IGF 1 IGF-1 Receptor IGF 1 Receptor Receptor, IGF-1 Receptors, Insulin-Like-Growth Factor I IGF-I Receptor IGF I Receptor Receptor, Insulin-Like Growth Factor Type 1 Receptor, IGF-I Receptor, IGF I Receptor, Insulin-Like Growth Factor I Insulin-Like-Growth Factor I Receptor Insulin Like Growth Factor I Receptor IGF Type 1 Receptor Receptor, IGF Type 1 beta Subunit Receptor, IGF Type 1 beta Subunit Receptor, IGF Type 1 alpha Subunit Receptor, IGF Type 1 alpha Subunit

Below are MeSH descriptors whose meaning is more general than "Receptor, IGF Type 1".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
Receptor Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.400]
Receptor, IGF Type 1 [D08.811.913.696.620.682.725.400.185]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptor Protein-Tyrosine Kinases [D12.776.543.750.630]
Receptor, IGF Type 1 [D12.776.543.750.630.468]
Receptors, Peptide [D12.776.543.750.750]
Receptors, Growth Factor [D12.776.543.750.750.400]
Receptors, Somatomedin [D12.776.543.750.750.400.780]
Receptor, IGF Type 1 [D12.776.543.750.750.400.780.400]

Below are MeSH descriptors whose meaning is related to "Receptor, IGF Type 1".

Below are MeSH descriptors whose meaning is more specific than "Receptor, IGF Type 1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptor, IGF Type 1" by people in this website by year, and whether "Receptor, IGF Type 1" was a major or minor topic of these publications.

Bar chart showing 30 publications over 16 distinct years, with a maximum of 4 publications in 2008 and 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	1	0	1
1995	1	0	1
1996	1	0	1
1998	0	1	1
2000	0	1	1
2004	0	1	1
2006	2	1	3
2007	1	1	2
2008	2	2	4
2010	1	1	2
2011	1	3	4
2013	0	2	2
2015	2	0	2
2017	1	1	2
2019	1	1	2
2020	0	1	1

Below are the most recent publications written about "Receptor, IGF Type 1" by people in Profiles.

Rosenzweig SA. The Continuing Evolution of Insulin-like Growth Factor Signaling. F1000Res. 2020; 9.

View in: PubMed
Garrett SM, Hsu E, Thomas JM, Pilewski JM, Feghali-Bostwick C. Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions. PLoS One. 2019; 14(11):e0225422.

View in: PubMed
Wang K, Shen H, Gan P, Cavallero S, Kumar SR, Lien CL, Sucov HM. Differential roles of insulin like growth factor 1 receptor and insulin receptor during embryonic heart development. BMC Dev Biol. 2019 03 25; 19(1):5.

View in: PubMed
Aleksic T, Verrill C, Bryant RJ, Han C, Worrall AR, Brureau L, Larré S, Higgins GS, Fazal F, Sabbagh A, Haider S, Buffa FM, Cole D, Macaulay VM. IGF-1R associates with adverse outcomes after radical radiotherapy for prostate cancer. Br J Cancer. 2017 Nov 21; 117(11):1600-1606.

View in: PubMed
Szymkowicz DB, Sims KC, Castro NM, Bridges WC, Bain LJ. Embryonic-only arsenic exposure in killifish (Fundulus heteroclitus) reduces growth and alters muscle IGF levels one year later. Aquat Toxicol. 2017 May; 186:1-10.

View in: PubMed
Yu EY, Li H, Higano CS, Agarwal N, Pal SK, Alva A, Heath EI, Lam ET, Gupta S, Lilly MB, Inoue Y, Chi KN, Vogelzang NJ, Quinn DI, Cheng HH, Plymate SR, Hussain M, Tangen CM, Thompson IM. SWOG S0925: A Randomized Phase II Study of Androgen Deprivation Combined With Cixutumumab Versus Androgen Deprivation Alone in Patients With New Metastatic Hormone-Sensitive Prostate Cancer. J Clin Oncol. 2015 May 10; 33(14):1601-8.

View in: PubMed
Ilatovskaya DV, Levchenko V, Brands MW, Pavlov TS, Staruschenko A. Cross-talk between insulin and IGF-1 receptors in the cortical collecting duct principal cells: implication for ENaC-mediated Na+ reabsorption. Am J Physiol Renal Physiol. 2015 Apr 01; 308(7):F713-9.

View in: PubMed
Hung CF, Rohani MG, Lee SS, Chen P, Schnapp LM. Role of IGF-1 pathway in lung fibroblast activation. Respir Res. 2013 Oct 08; 14:102.

View in: PubMed
Schwartz GK, Tap WD, Qin LX, Livingston MB, Undevia SD, Chmielowski B, Agulnik M, Schuetze SM, Reed DR, Okuno SH, Ludwig JA, Keedy V, Rietschel P, Kraft AS, Adkins D, Van Tine BA, Brockstein B, Yim V, Bitas C, Abdullah A, Antonescu CR, Condy M, Dickson MA, Vasudeva SD, Ho AL, Doyle LA, Chen HX, Maki RG. Cixutumumab and temsirolimus for patients with bone and soft-tissue sarcoma: a multicentre, open-label, phase 2 trial. Lancet Oncol. 2013 Apr; 14(4):371-82.

View in: PubMed
Rosenzweig SA. Acquired resistance to drugs targeting receptor tyrosine kinases. Biochem Pharmacol. 2012 Apr 15; 83(8):1041-8.

View in: PubMed

People

Explore

Similar Concepts

Top Journals