F-Box Proteins

"F-Box Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of proteins that share the F-BOX MOTIF and are involved in protein-protein interactions. They play an important role in process of protein ubiquition by associating with a variety of substrates and then associating into SCF UBIQUITIN LIGASE complexes. They are held in the ubiquitin-ligase complex via binding to SKP DOMAIN PROTEINS.

Descriptor ID	D044783
MeSH Number(s)	D12.776.157.169
Concept/Terms	F-Box Proteins F-Box Proteins F Box Proteins F-Box Domain Protein Domain Protein, F-Box F Box Domain Protein Protein, F-Box Domain F-Box Protein Family F Box Protein Family Protein Family, F-Box

Below are MeSH descriptors whose meaning is more general than "F-Box Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
F-Box Proteins [D12.776.157.169]

Below are MeSH descriptors whose meaning is related to "F-Box Proteins".

Below are MeSH descriptors whose meaning is more specific than "F-Box Proteins".

F-Box Proteins
beta-Transducin Repeat-Containing Proteins
F-Box-WD Repeat-Containing Protein 7

publications

Timeline | Most Recent

This graph shows the total number of publications written about "F-Box Proteins" by people in this website by year, and whether "F-Box Proteins" was a major or minor topic of these publications.

Bar chart showing 7 publications over 7 distinct years, with a maximum of 1 publications in 2004 and 2010 and 2011 and 2013 and 2016 and 2017 and 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	1	0	1
2010	1	0	1
2011	0	1	1
2013	1	0	1
2016	1	0	1
2017	1	0	1
2019	0	1	1

Below are the most recent publications written about "F-Box Proteins" by people in Profiles.

Qie S, Yoshida A, Parnham S, Oleinik N, Beeson GC, Beeson CC, Ogretmen B, Bass AJ, Wong KK, Rustgi AK, Diehl JA. Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma. Nat Commun. 2019 03 21; 10(1):1296.

View in: PubMed
Qie S, Majumder M, Mackiewicz K, Howley BV, Peterson YK, Howe PH, Palanisamy V, Diehl JA. Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma. Nat Commun. 2017 11 16; 8(1):1534.

View in: PubMed
Kothari N, Teer JK, Abbott AM, Srikumar T, Zhang Y, Yoder SJ, Brohl AS, Kim RD, Reed DR, Shibata D. Increased incidence of FBXW7 and POLE proofreading domain mutations in young adult colorectal cancers. Cancer. 2016 09 15; 122(18):2828-35.

View in: PubMed
Lian Z, Lee EK, Bass AJ, Wong KK, Klein-Szanto AJ, Rustgi AK, Diehl JA. FBXO4 loss facilitates carcinogen induced papilloma development in mice. Cancer Biol Ther. 2015; 16(5):750-5.

View in: PubMed
Lee EK, Lian Z, D'Andrea K, Letrero R, Sheng W, Liu S, Diehl JN, Pytel D, Barbash O, Schuchter L, Amaravaradi R, Xu X, Herlyn M, Nathanson KL, Diehl JA. The FBXO4 tumor suppressor functions as a barrier to BRAFV600E-dependent metastatic melanoma. Mol Cell Biol. 2013 Nov; 33(22):4422-33.

View in: PubMed
Smits BM, Traun BD, Devries TL, Tran A, Samuelson D, Haag JD, Gould M. An insulator loop resides between the synthetically interacting elements of the human/rat conserved breast cancer susceptibility locus MCS5A/Mcs5a. Nucleic Acids Res. 2012 Jan; 40(1):132-47.

View in: PubMed
Vaites LP, Lee EK, Lian Z, Barbash O, Roy D, Wasik M, Klein-Szanto AJ, Rustgi AK, Diehl JA. The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation. Mol Cell Biol. 2011 Nov; 31(22):4513-23.

View in: PubMed
Barbash O, Lee EK, Diehl JA. Phosphorylation-dependent regulation of SCF(Fbx4) dimerization and activity involves a novel component, 14-3-3?. Oncogene. 2011 Apr 28; 30(17):1995-2002.

View in: PubMed
Bairwa NK, Mohanty BK, Stamenova R, Curcio MJ, Bastia D. The intra-S phase checkpoint protein Tof1 collaborates with the helicase Rrm3 and the F-box protein Dia2 to maintain genome stability in Saccharomyces cerevisiae. J Biol Chem. 2011 Jan 28; 286(4):2445-54.

View in: PubMed
Aggarwal P, Vaites LP, Kim JK, Mellert H, Gurung B, Nakagawa H, Herlyn M, Hua X, Rustgi AK, McMahon SB, Diehl JA. Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. Cancer Cell. 2010 Oct 19; 18(4):329-40.

View in: PubMed

People

Explore

Similar Concepts

Top Journals