Factor XII

"Factor XII" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

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Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III.


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This graph shows the total number of publications written about "Factor XII" by people in this website by year, and whether "Factor XII" was a major or minor topic of these publications.
Bar chart showing 42 publications over 22 distinct years, with a maximum of 3 publications in 1993 and 1997 and 1999 and 2001 and 2002 and 2014 and 2021
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