"Cathepsins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of lysosomal proteinases or endopeptidases found in aqueous extracts of a variety of animal tissues. They function optimally within an acidic pH range. The cathepsins occur as a variety of enzyme subtypes including SERINE PROTEASES; ASPARTIC PROTEINASES; and CYSTEINE PROTEASES.
| Descriptor ID |
D002403
|
| MeSH Number(s) |
D08.811.277.656.224
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Cathepsins".
Below are MeSH descriptors whose meaning is more specific than "Cathepsins".
This graph shows the total number of publications written about "Cathepsins" by people in this website by year, and whether "Cathepsins" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 1 | 2 |
| 2007 | 2 | 3 | 5 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 2 | 3 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 2 | 3 |
| 2016 | 2 | 0 | 2 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cathepsins" by people in Profiles.
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Inhibition of acid ceramidase regulates MHC class II antigen presentation and suppression of autoimmune arthritis. Cytokine. 2020 11; 135:155219.
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Differential hypertensive protease expression in the thoracic versus abdominal aorta. J Vasc Surg. 2017 11; 66(5):1543-1552.
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Chronic cathepsin inhibition by E-64 in Dahl salt-sensitive rats. Physiol Rep. 2016 09; 4(17).
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Porphyromonas gingivalis promotes monocyte migration by activating MMP-9. J Periodontal Res. 2012 Apr; 47(2):236-42.
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Mechanisms regulating enhanced human leukocyte antigen class II-mediated CD4 + T cell recognition of human B-cell lymphoma by resveratrol. Leuk Lymphoma. 2012 Feb; 53(2):305-14.
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Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease. Biochim Biophys Acta. 2012 Jan; 1824(1):89-104.
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Bortezomib blocks the catabolic process of autophagy via a cathepsin-dependent mechanism, affects endoplasmic reticulum stress and induces caspase-dependent cell death in antiestrogen-sensitive and resistant ER+ breast cancer cells. Autophagy. 2010 Jan; 6(1):19-35.
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Defective co-activator recruitment in osteoclasts from microphthalmia-oak ridge mutant mice. J Cell Physiol. 2009 Jul; 220(1):230-7.
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N-(4-Hydroxyphenyl) retinamide potentiated paclitaxel for cell cycle arrest and apoptosis in glioblastoma C6 and RG2 cells. Brain Res. 2009 May 01; 1268:142-153.
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Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K. Circ Res. 2009 Feb 27; 104(4):455-65.