Proteasome Endopeptidase Complex
"Proteasome Endopeptidase Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.
| Descriptor ID |
D046988
|
| MeSH Number(s) |
D05.500.562.500 D08.811.277.656.918 D08.811.600.730
|
| Concept/Terms |
Proteasome Endopeptidase Complex- Proteasome Endopeptidase Complex
- Complex, Proteasome Endopeptidase
- Endopeptidase Complex, Proteasome
- Macropain
- Macroxyproteinase
- Multicatalytic Proteinase
- Proteinase, Multicatalytic
- Prosome
- Proteasome
- 20S Proteasome
- Proteasome, 20S
- Multicatalytic Endopeptidase Complex
- Complex, Multicatalytic Endopeptidase
- Endopeptidase Complex, Multicatalytic
|
Below are MeSH descriptors whose meaning is more general than "Proteasome Endopeptidase Complex".
Below are MeSH descriptors whose meaning is more specific than "Proteasome Endopeptidase Complex".
This graph shows the total number of publications written about "Proteasome Endopeptidase Complex" by people in this website by year, and whether "Proteasome Endopeptidase Complex" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2002 | 1 | 3 | 4 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 3 | 3 |
| 2005 | 0 | 5 | 5 |
| 2006 | 1 | 0 | 1 |
| 2007 | 3 | 1 | 4 |
| 2008 | 0 | 4 | 4 |
| 2009 | 1 | 2 | 3 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 3 | 3 |
| 2014 | 1 | 2 | 3 |
| 2015 | 0 | 3 | 3 |
| 2016 | 0 | 3 | 3 |
| 2018 | 0 | 2 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 1 | 2 |
| 2021 | 0 | 2 | 2 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Proteasome Endopeptidase Complex" by people in Profiles.
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Stress-Mediated Attenuation of Translation Undermines T-cell Activity in Cancer. Cancer Res. 2022 12 02; 82(23):4386-4399.
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Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity. Nat Commun. 2021 11 25; 12(1):6896.
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Sphingosine kinase 1 downregulation is required for adaptation to serine deprivation. FASEB J. 2021 02; 35(2):e21284.
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Caveolin-1 stabilizes ATP7A, a copper transporter for extracellular SOD, in vascular tissue to maintain endothelial function. Am J Physiol Cell Physiol. 2020 11 01; 319(5):C933-C944.
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The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction. Circ Res. 2020 07 31; 127(4):502-518.
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Proteasome inhibition suppress microgravity elevated RANK signaling during osteoclast differentiation. Cytokine. 2020 01; 125:154821.
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Pan-PIM kinase inhibitors enhance Lenalidomide's anti-myeloma activity via cereblon-IKZF1/3 cascade. Cancer Lett. 2019 01; 440-441:1-10.
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The retinoid X receptor agonist, 9-cis UAB30, inhibits cutaneous T-cell lymphoma proliferation through the SKP2-p27kip1 axis. J Dermatol Sci. 2018 Jun; 90(3):343-356.
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Commentary on "Proteasome Inhibitors: A Novel Class of Potent and Effective Antitumor Agents". Cancer Res. 2016 09 01; 76(17):4916-7.
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Sarcoidosis activates diverse transcriptional programs in bronchoalveolar lavage cells. Respir Res. 2016 07 26; 17(1):93.