"Protamines" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino acids. Protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralize the anticoagulant action of heparin in the treatment of heparin overdose. (From Merck Index, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p692)
| Descriptor ID |
D011479
|
| MeSH Number(s) |
D12.776.660.750 D12.776.664.750
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Protamines".
Below are MeSH descriptors whose meaning is more specific than "Protamines".
This graph shows the total number of publications written about "Protamines" by people in this website by year, and whether "Protamines" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 2 | 0 | 2 |
| 1995 | 3 | 0 | 3 |
| 1996 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 2001 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protamines" by people in Profiles.
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Crk1/2 and CrkL form a hetero-oligomer and functionally complement each other during podocyte morphogenesis. Kidney Int. 2014 Jun; 85(6):1382-1394.
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Reversible shear-mediated platelet dysfunction during cardiac surgery as assessed by the PFA-100 platelet function analyzer. Blood Coagul Fibrinolysis. 2001 Mar; 12(2):85-93.
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Differential effects of novel protamine variants on myocyte contractile function with left ventricular failure. Surgery. 1997 Mar; 121(3):304-13.
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Direct and interactive effects of cardioplegic arrest and protamine on myocyte contractility. Ann Thorac Surg. 1996 Aug; 62(2):489-94.
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Direct effects of protamine sulfate on myocyte contractile processes. Cellular and molecular mechanisms. Circulation. 1995 Nov 01; 92(9 Suppl):II433-46.
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Protamine use during peripheral vascular surgery: a prospective randomized trial. J Vasc Surg. 1995 Sep; 22(3):248-55; discussion 256.
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Differential effects of protamine sulfate on myocyte contractile function with left ventricular failure. J Am Coll Cardiol. 1995 Mar 01; 25(3):773-80.
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The direct effects of protamine sulfate on myocyte contractile processes. J Thorac Cardiovasc Surg. 1994 Dec; 108(6):1100-14.
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Effects of protamine on myocyte contractile function and beta-adrenergic responsiveness. Ann Thorac Surg. 1994 May; 57(5):1066-74; discussion 1074-5.
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Absence of complement-mediated events after protamine reversal of heparin anticoagulation. J Surg Res. 1991 Jul; 51(1):72-6.