Proliferating Cell Nuclear Antigen
"Proliferating Cell Nuclear Antigen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
| Descriptor ID |
D018809
|
| MeSH Number(s) |
D12.776.660.740 D23.050.290.750 D23.101.140.600
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Proliferating Cell Nuclear Antigen".
Below are MeSH descriptors whose meaning is more specific than "Proliferating Cell Nuclear Antigen".
This graph shows the total number of publications written about "Proliferating Cell Nuclear Antigen" by people in this website by year, and whether "Proliferating Cell Nuclear Antigen" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2004 | 0 | 3 | 3 |
| 2005 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 2 | 2 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Proliferating Cell Nuclear Antigen" by people in Profiles.
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Exposure to arsenic during embryogenesis impairs olfactory sensory neuron differentiation and function into adulthood. Toxicology. 2019 05 15; 420:73-84.
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Global Implications of Blood Pressure Thresholds and Targets: Guideline Conversations From the World Hypertension League. Hypertension. 2018 06; 71(6):985-987.
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Immunohistochemical investigation of F344/N rat islet cell tumors from national toxicology program studies. Toxicol Pathol. 2012 Jul; 40(5):751-63.
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Knockout of the neurokinin-1 receptor reduces cholangiocyte proliferation in bile duct-ligated mice. Am J Physiol Gastrointest Liver Physiol. 2011 Aug; 301(2):G297-305.
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NIM811 prevents mitochondrial dysfunction, attenuates liver injury, and stimulates liver regeneration after massive hepatectomy. Transplantation. 2011 Feb 27; 91(4):406-12.
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Mice deficient in the serine/threonine protein kinase VRK1 are infertile due to a progressive loss of spermatogonia. Biol Reprod. 2010 Jan; 82(1):182-93.
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N-(4-Hydroxyphenyl) retinamide potentiated paclitaxel for cell cycle arrest and apoptosis in glioblastoma C6 and RG2 cells. Brain Res. 2009 May 01; 1268:142-153.
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Ischemic preconditioning prevents free radical production and mitochondrial depolarization in small-for-size rat liver grafts. Transplantation. 2008 May 15; 85(9):1322-31.
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TGFbeta1 and TGFalpha contrarily affect alveolar survival and tumorigenesis in mouse mammary epithelium. Int J Cancer. 2007 Feb 01; 120(3):493-9.
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Tissue engineering of heart valves by recellularization of glutaraldehyde-fixed porcine valves using bone marrow-derived cells. Exp Mol Med. 2006 Jun 30; 38(3):273-83.